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The map label for this gene is tyrS [H]

Identifier: 123969061

GI number: 123969061

Start: 1309246

End: 1310484

Strand: Reverse

Name: tyrS [H]

Synonym: A9601_15291

Alternate gene names: 123969061

Gene position: 1310484-1309246 (Counterclockwise)

Preceding gene: 123969062

Following gene: 123969060

Centisome position: 78.48

GC content: 31.64

Gene sequence:

>1239_bases
ATGTCAGATAATTTAATAATTCCATCATGGCTTTCAAGAGGAATAGAAGAATATTTTCCAATTAAGGGAACAGATCAAAC
CTTTTTGGAGATAATTGATTATGCGAAAAAAAATAATAAAAAATTAAGGGTTAAACTCGGGATCGATCCAACCGGAACAG
ATATTCATCTTGGGCACAGCATATTGTTTAAAAAACTTAGGGCGTTCCAAGATAATGGACATATTGCAGTTCTAATTATT
GGCGATTTTACTGCTCAAATTGGAGACCCAACCGGAAAAAACAAAACAAGAGTTCAGTTATCGGAAAAACAAGTTAAGGA
TAATGCAAAAACATATTTAACCCAATTAGGGATGGGAAAGCCAGCTAATGAATCTATTTTAGATTTTGATTCAAAAGATA
GAATAGAAATTAGATATAACAGTGAATGGTTAAAAGGATTAAATCTTAATTCGATAATTGAATTAATGGGGAGTGCGACA
GTTAGTCAAATGCTAGCTAAGGAGGAATTTAATAAAAGGTACACTTCGCAAGTTCCAATTGCTTTGCATGAATTCTTATA
TCCACTATTACAAGGTTATGATTCGGTAGTTGTTCAATCAGATATTGAGCTTGGAGGTACAGATCAGAAATTTAATATTG
CAATAGGAAGAGATCTTCAAAGGCATTTTAAACAAGAGCCTCAATTTGGTGTTCTGCTGCCAATTTTGACAGGTTTAGAT
GGTATTAAGAAGATGAGTAAATCTGAATTTAACACCGTCGGTTTGAGTGAAGATCCTCTTTCAATGTATTCAAAATTAGA
AAAAGTACCTGATAATATAATTCCTACCTATTTTGAATTACTTACTGAATTAGATTTAAGGTTTCTTGAAAACTCAAATC
CTCGTGAATTACAGAGAAGAATGGCTTTAGAAGTTACTACTTTATTCCATGGGGCTGAAGAAGCATTAAAGGCGCAATCA
AATTGCGAAAAATTATTCCTTGGACAAAAAGAAAAAGTTGGAGAAATTCCAGAGATTTCTATAAAAGAAGTAGTTTTCCC
AGTAAAGTTTTTTTACTTGTTAAGTGCTCTAAAACTTTTCAAATCTAGCAGCGAATCCAAAAGATCTATTAAAGGAGGGG
GTGTAAAAATTGATAGTCAAAAAGTAACAAATCCTGATTTAGTTTTTAATTCAAAAAATGATTTGGAAGGGAAAATTTTG
CAAATTGGAAAAAAAATAATTAAGAGGTTTGAAAACTAA

Upstream 100 bases:

>100_bases
TGGGATTACTCCTGATCAAATGTTCGATCAAATGAATAAAACTTTAATAAGAATGAAGGATGAACTTGATAAAACTTCTT
AAATTTAACTGTTAAACTTC

Downstream 100 bases:

>100_bases
AAATTGATGAATAAAAGATTTAATTCAGAAGATAAAATAATATTGGCAATTGATGGATTAGATTTAAGTCAAGCAAAATT
ACTTCTGGAAAAATGTCCCC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSDNLIIPSWLSRGIEEYFPIKGTDQTFLEIIDYAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLSEDPLSMYSKLEKVPDNIIPTYFELLTELDLRFLENSNPRELQRRMALEVTTLFHGAEEALKAQS
NCEKLFLGQKEKVGEIPEISIKEVVFPVKFFYLLSALKLFKSSSESKRSIKGGGVKIDSQKVTNPDLVFNSKNDLEGKIL
QIGKKIIKRFEN

Sequences:

>Translated_412_residues
MSDNLIIPSWLSRGIEEYFPIKGTDQTFLEIIDYAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLII
GDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSAT
VSQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
GIKKMSKSEFNTVGLSEDPLSMYSKLEKVPDNIIPTYFELLTELDLRFLENSNPRELQRRMALEVTTLFHGAEEALKAQS
NCEKLFLGQKEKVGEIPEISIKEVVFPVKFFYLLSALKLFKSSSESKRSIKGGGVKIDSQKVTNPDLVFNSKNDLEGKIL
QIGKKIIKRFEN
>Mature_411_residues
SDNLIIPSWLSRGIEEYFPIKGTDQTFLEIIDYAKKNNKKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHIAVLIIG
DFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGKPANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATV
SQMLAKEEFNKRYTSQVPIALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLDG
IKKMSKSEFNTVGLSEDPLSMYSKLEKVPDNIIPTYFELLTELDLRFLENSNPRELQRRMALEVTTLFHGAEEALKAQSN
CEKLFLGQKEKVGEIPEISIKEVVFPVKFFYLLSALKLFKSSSESKRSIKGGGVKIDSQKVTNPDLVFNSKNDLEGKILQ
IGKKIIKRFEN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=430, Percent_Identity=28.3720930232558, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1787925, Length=388, Percent_Identity=28.8659793814433, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI25145802, Length=322, Percent_Identity=25.776397515528, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325160, Length=303, Percent_Identity=26.7326732673267, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20130383, Length=429, Percent_Identity=26.1072261072261, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46607; Mature: 46476

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLIIPSWLSRGIEEYFPIKGTDQTFLEIIDYAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCCEECHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYTSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLSEDPLSMYSKLEKVPDNIIPTYFELLTELDLRFLENSNPRELQRR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGAEEALKAQSNCEKLFLGQKEKVGEIPEISIKEVVFPVKFFYLLSALKLF
HHHHHHHHHHCHHHHHHHHHCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSQKVTNPDLVFNSKNDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDNLIIPSWLSRGIEEYFPIKGTDQTFLEIIDYAKKNNKKLRVKLGIDPTGTDIHLGHS
CCCEECHHHHHCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCHH
ILFKKLRAFQDNGHIAVLIIGDFTAQIGDPTGKNKTRVQLSEKQVKDNAKTYLTQLGMGK
HHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCC
PANESILDFDSKDRIEIRYNSEWLKGLNLNSIIELMGSATVSQMLAKEEFNKRYTSQVPI
CCCCCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALHEFLYPLLQGYDSVVVQSDIELGGTDQKFNIAIGRDLQRHFKQEPQFGVLLPILTGLD
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCCCHHHHHHCHH
GIKKMSKSEFNTVGLSEDPLSMYSKLEKVPDNIIPTYFELLTELDLRFLENSNPRELQRR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
MALEVTTLFHGAEEALKAQSNCEKLFLGQKEKVGEIPEISIKEVVFPVKFFYLLSALKLF
HHHHHHHHHHCHHHHHHHHHCHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSSSESKRSIKGGGVKIDSQKVTNPDLVFNSKNDLEGKILQIGKKIIKRFEN
HCCCHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA