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The map label for this gene is hemN [C]

Identifier: 123969042

GI number: 123969042

Start: 1293792

End: 1295015

Strand: Reverse

Name: hemN [C]

Synonym: A9601_15101

Alternate gene names: 123969042

Gene position: 1295015-1293792 (Counterclockwise)

Preceding gene: 123969050

Following gene: 123969035

Centisome position: 77.55

GC content: 32.03

Gene sequence:

>1224_bases
ATGAATAAGTTTCCAAGAAGTGCTTATGTGCACATTCCTTTTTGCCACAGAAGATGTTTTTATTGTGATTTTGCAGTTAT
TCCATTAGGAAACAAAGTTGAAACTTTAAAAGGTTATGGAAGCAAAACTGTTCAAGAGTATTTGCAATTTTTATTTAAAG
AAATATTGTCAATTAAACATAAATCACCTCTATCGACAATTTATATAGGAGGTGGTACACCATCAATTTTAGATCCCAGC
CAAATCAAAGAATTAATTGATCTTTTTAAAGAAAATTATGGCATTGACTATGGTGCTGAAATCACTATGGAGATTGATCC
AGCTAGTTTTACTCAAGATGATCTTTTTGGATTCATAAATGCTGGGATAAATAGATTTAGTCTCGGAGTACAAAGTTTTA
ATAATCAGGTACTTCAAAAGTCGGGAAGGCGTCATTTGAAAGAAGATGCAGAAAAATCTTGTTTCTGGTTGAAGAGAGAA
TATGATTCTGGGTTAATAAAAAGCTGGAGTTTAGATTTAATACAAAACTTGCCACTTAGTGGATTTAAAGAATGGCAAGA
TGACTTAAAAAAAGCAATAACATTTTCACCGCCGCATCTATCTATTTACGATTTAAATATTGAAAATGGCACTGTTTTTA
AGAAATTAGTTAATTTAGGCAAATTAAAACTCCCAAGTGATGAAGAAGCTGTTAGAAATAGTGAATCAACACATTTAATT
TTAAAAAACTTAGGGTATTCAAGATATGAAATCTCAAACTATTGCCTTCCGGGACATCAATCGAGACACAATAGAGTTTA
TTGGAGTGGTTTAGGCTGGTGGGGTTTTGGTCAAGGCTCCACTAGTTCACCTTGGGGGGAAAAATTAACTAGACCAAGAG
TTAGTAAAGAATATAAAGAATGGGTAATTAGACAATACGAATTTAATTTAGATTCATCCTTAACTAATAAGGATTTTGTC
TACAAAGAACTTGATGAGAAAATAATGTTGGGATTAAGACTCAAAGAGGGTTTAGATATCAAAAAAGTGTTTCAAGAACA
AAACTGGGAGAACAAAAAATTTGAAAGCAACTTTAGTAAATTGCTCAAAGAATGGGAAAGGTTTCTTGAAAGTGGACTTT
TAGTAAGAAAGGGTTATAGATTCTTTTTAAGTGAGCCTAATGGCATGGAACTAAGCAATCAAGTTCTTGTTTCTATGTTT
AAGTGGTGGGATGAGATTAATTAA

Upstream 100 bases:

>100_bases
GTCATATATATAATCTACTAGGATTTATTAATTGAGTAAATAAGGATCTTATTTTTTTGATCCTTAATACTTTTTTGGAG
CTTAAGAATGAATTTATATT

Downstream 100 bases:

>100_bases
GTCTTTCAGAGTCTACCCATTCTTTTAATTTATCCTTAAATAATTTCTTTCCCTGGATAATTGGTTGGCAAAATGGTGGT
TGATCATCATTTAGGCCTAA

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNKVETLKGYGSKTVQEYLQFLFKEILSIKHKSPLSTIYIGGGTPSILDPS
QIKELIDLFKENYGIDYGAEITMEIDPASFTQDDLFGFINAGINRFSLGVQSFNNQVLQKSGRRHLKEDAEKSCFWLKRE
YDSGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIENGTVFKKLVNLGKLKLPSDEEAVRNSESTHLI
LKNLGYSRYEISNYCLPGHQSRHNRVYWSGLGWWGFGQGSTSSPWGEKLTRPRVSKEYKEWVIRQYEFNLDSSLTNKDFV
YKELDEKIMLGLRLKEGLDIKKVFQEQNWENKKFESNFSKLLKEWERFLESGLLVRKGYRFFLSEPNGMELSNQVLVSMF
KWWDEIN

Sequences:

>Translated_407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNKVETLKGYGSKTVQEYLQFLFKEILSIKHKSPLSTIYIGGGTPSILDPS
QIKELIDLFKENYGIDYGAEITMEIDPASFTQDDLFGFINAGINRFSLGVQSFNNQVLQKSGRRHLKEDAEKSCFWLKRE
YDSGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIENGTVFKKLVNLGKLKLPSDEEAVRNSESTHLI
LKNLGYSRYEISNYCLPGHQSRHNRVYWSGLGWWGFGQGSTSSPWGEKLTRPRVSKEYKEWVIRQYEFNLDSSLTNKDFV
YKELDEKIMLGLRLKEGLDIKKVFQEQNWENKKFESNFSKLLKEWERFLESGLLVRKGYRFFLSEPNGMELSNQVLVSMF
KWWDEIN
>Mature_407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNKVETLKGYGSKTVQEYLQFLFKEILSIKHKSPLSTIYIGGGTPSILDPS
QIKELIDLFKENYGIDYGAEITMEIDPASFTQDDLFGFINAGINRFSLGVQSFNNQVLQKSGRRHLKEDAEKSCFWLKRE
YDSGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIENGTVFKKLVNLGKLKLPSDEEAVRNSESTHLI
LKNLGYSRYEISNYCLPGHQSRHNRVYWSGLGWWGFGQGSTSSPWGEKLTRPRVSKEYKEWVIRQYEFNLDSSLTNKDFV
YKELDEKIMLGLRLKEGLDIKKVFQEQNWENKKFESNFSKLLKEWERFLESGLLVRKGYRFFLSEPNGMELSNQVLVSMF
KWWDEIN

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=273, Percent_Identity=29.6703296703297, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1789325, Length=326, Percent_Identity=33.7423312883436, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082341, Length=259, Percent_Identity=30.8880308880309, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 47489; Mature: 47489

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNKVETLKGYGSKTVQEYLQFLFKEILSIKH
CCCCCCCCEEEEEHHHCEEEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KSPLSTIYIGGGTPSILDPSQIKELIDLFKENYGIDYGAEITMEIDPASFTQDDLFGFIN
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGINRFSLGVQSFNNQVLQKSGRRHLKEDAEKSCFWLKREYDSGLIKSWSLDLIQNLPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
GFKEWQDDLKKAITFSPPHLSIYDLNIENGTVFKKLVNLGKLKLPSDEEAVRNSESTHLI
CHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEH
LKNLGYSRYEISNYCLPGHQSRHNRVYWSGLGWWGFGQGSTSSPWGEKLTRPRVSKEYKE
HHHCCCCEEECCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHCCCHHHHHHHH
WVIRQYEFNLDSSLTNKDFVYKELDEKIMLGLRLKEGLDIKKVFQEQNWENKKFESNFSK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
LLKEWERFLESGLLVRKGYRFFLSEPNGMELSNQVLVSMFKWWDEIN
HHHHHHHHHHCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNKVETLKGYGSKTVQEYLQFLFKEILSIKH
CCCCCCCCEEEEEHHHCEEEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KSPLSTIYIGGGTPSILDPSQIKELIDLFKENYGIDYGAEITMEIDPASFTQDDLFGFIN
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGINRFSLGVQSFNNQVLQKSGRRHLKEDAEKSCFWLKREYDSGLIKSWSLDLIQNLPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
GFKEWQDDLKKAITFSPPHLSIYDLNIENGTVFKKLVNLGKLKLPSDEEAVRNSESTHLI
CHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEH
LKNLGYSRYEISNYCLPGHQSRHNRVYWSGLGWWGFGQGSTSSPWGEKLTRPRVSKEYKE
HHHCCCCEEECCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHCCCHHHHHHHH
WVIRQYEFNLDSSLTNKDFVYKELDEKIMLGLRLKEGLDIKKVFQEQNWENKKFESNFSK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
LLKEWERFLESGLLVRKGYRFFLSEPNGMELSNQVLVSMFKWWDEIN
HHHHHHHHHHCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]