Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 123968987

GI number: 123968987

Start: 1239748

End: 1240662

Strand: Direct

Name: dxs [H]

Synonym: A9601_14551

Alternate gene names: 123968987

Gene position: 1239748-1240662 (Clockwise)

Preceding gene: 123968986

Following gene: 123968988

Centisome position: 74.24

GC content: 31.8

Gene sequence:

>915_bases
ATGAGAACTGCATTCGCAAAAGAAATAACAAACATCGCTGAAATGAGGAAAGATGTAGTTTTACTTTCTGGGGATATAGG
CAATAGAATGTTTGATGACTTTAAATTAATTGCAAATTCAAGATTTTTTAATTGTGGAATCGCTGAAAGTAATATGATGA
GTGTTGCCTCTGGTATGGCACTTTGCGGTTTGAGACCAATAATTTATACAATCACCCCATTTACCACTATTAGATGCTTA
GAACAAATAAAAATAGGTGCCGCTTATCACAAAGTTCCAGTAATAATTATCGGAACTGGTTCTGGGCTATCATATGCAGA
ATTAGGGGCAACTCATCATTCCTTAGATGATGTCTCAGTTATTAGATCTATTCCTGATATAAGAGTTCTTGCTCCATGCG
ACAGTAGCGAATTAAAAGCATTTTTACATCAATCTCTTCAAAGTGAATTCCCAACATATATGAGAATAGGAAAAAAAGGG
GAACCAATTCTTACTAAAGAATCTAGCAAGATTGAGATAGGGAAAGCGAATATACTTAAGGATGGGAATGACATAATTAT
TCTTGGAATTGGCCCAATTTTAAATGAAGCTTTAGAGGCTGCTAATAACAAAAATATTGATAGAGAAAAGGTATCTGTAG
TAAGTATGGGTTCAGTCAAGCCATTAGATACAAATTTTTTAAATCAAATTAACAAAAGAAAATTTAAGAAATGGATAATT
CTTGAAGAACACTCAATAATAGGAGGTTTGGGAAGTTCAATAATTGAGTGGAAAATAGATAATAAAATTAAGACTCCTGA
GATTAAAAGAATGGCAGCTCCAGATAAATTTATTCATAATCTTGGGAATCAAAAATATATAAGAAAAGAAATTGGACTTG
ACTCTAATTCAATCTTGCAAGAAATAATATTTTAA

Upstream 100 bases:

>100_bases
GAAAAGGAGTAAGTTTTATGGAAGATGATAATAATTGGCATTATAGAGTTCCAAACAATACAGAATTAGAAAATGCTCTT
CAAGAATTAGACAATATCAA

Downstream 100 bases:

>100_bases
TAATGAGAGTAGGATTTGATTTTGATAACACCTTAATAAACTATTATGGAGTTTTTTATGAAATAGCCCTTAGCAAGGGT
TTAATCCCGCCATCAATTAG

Product: transketolase C-terminal subunit

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRTAFAKEITNIAEMRKDVVLLSGDIGNRMFDDFKLIANSRFFNCGIAESNMMSVASGMALCGLRPIIYTITPFTTIRCL
EQIKIGAAYHKVPVIIIGTGSGLSYAELGATHHSLDDVSVIRSIPDIRVLAPCDSSELKAFLHQSLQSEFPTYMRIGKKG
EPILTKESSKIEIGKANILKDGNDIIILGIGPILNEALEAANNKNIDREKVSVVSMGSVKPLDTNFLNQINKRKFKKWII
LEEHSIIGGLGSSIIEWKIDNKIKTPEIKRMAAPDKFIHNLGNQKYIRKEIGLDSNSILQEIIF

Sequences:

>Translated_304_residues
MRTAFAKEITNIAEMRKDVVLLSGDIGNRMFDDFKLIANSRFFNCGIAESNMMSVASGMALCGLRPIIYTITPFTTIRCL
EQIKIGAAYHKVPVIIIGTGSGLSYAELGATHHSLDDVSVIRSIPDIRVLAPCDSSELKAFLHQSLQSEFPTYMRIGKKG
EPILTKESSKIEIGKANILKDGNDIIILGIGPILNEALEAANNKNIDREKVSVVSMGSVKPLDTNFLNQINKRKFKKWII
LEEHSIIGGLGSSIIEWKIDNKIKTPEIKRMAAPDKFIHNLGNQKYIRKEIGLDSNSILQEIIF
>Mature_304_residues
MRTAFAKEITNIAEMRKDVVLLSGDIGNRMFDDFKLIANSRFFNCGIAESNMMSVASGMALCGLRPIIYTITPFTTIRCL
EQIKIGAAYHKVPVIIIGTGSGLSYAELGATHHSLDDVSVIRSIPDIRVLAPCDSSELKAFLHQSLQSEFPTYMRIGKKG
EPILTKESSKIEIGKANILKDGNDIIILGIGPILNEALEAANNKNIDREKVSVVSMGSVKPLDTNFLNQINKRKFKKWII
LEEHSIIGGLGSSIIEWKIDNKIKTPEIKRMAAPDKFIHNLGNQKYIRKEIGLDSNSILQEIIF

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=253, Percent_Identity=28.0632411067194, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI205277463, Length=260, Percent_Identity=26.5384615384615, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4507521, Length=260, Percent_Identity=26.5384615384615, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=258, Percent_Identity=27.1317829457364, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI225637463, Length=258, Percent_Identity=27.1317829457364, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI225637459, Length=258, Percent_Identity=27.1317829457364, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786622, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539652, Length=293, Percent_Identity=26.2798634812287, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645119, Length=292, Percent_Identity=25.3424657534247, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551847, Length=292, Percent_Identity=25.3424657534247, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550715, Length=292, Percent_Identity=25.3424657534247, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24666278, Length=265, Percent_Identity=26.4150943396226, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 33729; Mature: 33729

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAFAKEITNIAEMRKDVVLLSGDIGNRMFDDFKLIANSRFFNCGIAESNMMSVASGMA
CCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHH
LCGLRPIIYTITPFTTIRCLEQIKIGAAYHKVPVIIIGTGSGLSYAELGATHHSLDDVSV
HHCCCCEEEEECCHHHHHHHHHHHHCCEEECCCEEEEECCCCCCHHHHCCCCCCHHHHHH
IRSIPDIRVLAPCDSSELKAFLHQSLQSEFPTYMRIGKKGEPILTKESSKIEIGKANILK
HHCCCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCEEEECCCCEEE
DGNDIIILGIGPILNEALEAANNKNIDREKVSVVSMGSVKPLDTNFLNQINKRKFKKWII
CCCCEEEEECCHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHEEE
LEEHSIIGGLGSSIIEWKIDNKIKTPEIKRMAAPDKFIHNLGNQKYIRKEIGLDSNSILQ
EECCCHHCCCCCCEEEEEECCCCCCCHHHHHCCCHHHHHHCCCHHHHHHHHCCCHHHHHH
EIIF
HHCC
>Mature Secondary Structure
MRTAFAKEITNIAEMRKDVVLLSGDIGNRMFDDFKLIANSRFFNCGIAESNMMSVASGMA
CCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHH
LCGLRPIIYTITPFTTIRCLEQIKIGAAYHKVPVIIIGTGSGLSYAELGATHHSLDDVSV
HHCCCCEEEEECCHHHHHHHHHHHHCCEEECCCEEEEECCCCCCHHHHCCCCCCHHHHHH
IRSIPDIRVLAPCDSSELKAFLHQSLQSEFPTYMRIGKKGEPILTKESSKIEIGKANILK
HHCCCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCEEEECCCCEEE
DGNDIIILGIGPILNEALEAANNKNIDREKVSVVSMGSVKPLDTNFLNQINKRKFKKWII
CCCCEEEEECCHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHEEE
LEEHSIIGGLGSSIIEWKIDNKIKTPEIKRMAAPDKFIHNLGNQKYIRKEIGLDSNSILQ
EECCCHHCCCCCCEEEEEECCCCCCCHHHHHCCCHHHHHHCCCHHHHHHHHCCCHHHHHH
EIIF
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA