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The map label for this gene is tktA [C]

Identifier: 123968986

GI number: 123968986

Start: 1238885

End: 1239751

Strand: Direct

Name: tktA [C]

Synonym: A9601_14541

Alternate gene names: 123968986

Gene position: 1238885-1239751 (Clockwise)

Preceding gene: 123968985

Following gene: 123968987

Centisome position: 74.19

GC content: 31.49

Gene sequence:

>867_bases
ATGCATAGATTAATGAAAAATTTAAAAAAATCATTTAAAGAAAAATATAATGAAAAAGAATTACAAAAAATTGCTACCAA
ATTAAGGAAAAAAATAATTACTACCTCTCATAGAGCAAAAATTCCACATTTAGGTTCTTGCTTATCTTGCATTGATTTAT
TAACCTATTTATATTGGAGTGAATTATTTATAAATCCCTCTGACCCAAAACATATAAATCGAGATAGATTTGTTCTTAGC
AAAGGACATGGAGCTCCAGCGATATTTCAAGTTTTAGCAGAAAAGAATTTTTTCCCAGTTACTGATCTTAATAACTTTGG
CAAGGCTGGAAGTTTATTTCATGAACATCCTCCTAAACCTGGTCTTGTTCCTGGGATTGAAGCTGCTACAGGATCACTTG
GGCATGGTTTGCCTATGGCTTTAGGAATGGCATTAGCGTCAAGGATTCTAAAACTTAATTTCAGATGTTATGCAATGCTC
AGTGATGGGGAATGCAATGAAGGAAGTATTTGGGAAGCTGCAATGATGGCTGCAAGTCAAAAAGTTGAAAACTTAATAGT
AATAATTGATTTTAATAAATGGCAAGCGACTGGAAGAAGTAAAGATATTTTAGCTTTAGATCCATTAAGAGAAAAATGGT
CTTCGTTTGGATGGCATACACAAGAAATTGATGGCCATGATTTTTCTCAAATAAATGATGCTTTTATAGAAGCTAGAAAG
ATTAAATCAAAGCCAAAAGCAATAATTGCAAATACTATAAAAGGAAAAGGAGTAAGTTTTATGGAAGATGATAATAATTG
GCATTATAGAGTTCCAAACAATACAGAATTAGAAAATGCTCTTCAAGAATTAGACAATATCAAATGA

Upstream 100 bases:

>100_bases
ACCATGGAATGGATTCAAGAAAACCTAGAAGTTTTGAAAAATATTTCTTGGAATTATTCTCACAAGTCTTGAGGAAAAAA
AAAAAAGATTTAAAAAATAT

Downstream 100 bases:

>100_bases
GAACTGCATTCGCAAAAGAAATAACAAACATCGCTGAAATGAGGAAAGATGTAGTTTTACTTTCTGGGGATATAGGCAAT
AGAATGTTTGATGACTTTAA

Product: N-terminal subunit of transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MHRLMKNLKKSFKEKYNEKELQKIATKLRKKIITTSHRAKIPHLGSCLSCIDLLTYLYWSELFINPSDPKHINRDRFVLS
KGHGAPAIFQVLAEKNFFPVTDLNNFGKAGSLFHEHPPKPGLVPGIEAATGSLGHGLPMALGMALASRILKLNFRCYAML
SDGECNEGSIWEAAMMAASQKVENLIVIIDFNKWQATGRSKDILALDPLREKWSSFGWHTQEIDGHDFSQINDAFIEARK
IKSKPKAIIANTIKGKGVSFMEDDNNWHYRVPNNTELENALQELDNIK

Sequences:

>Translated_288_residues
MHRLMKNLKKSFKEKYNEKELQKIATKLRKKIITTSHRAKIPHLGSCLSCIDLLTYLYWSELFINPSDPKHINRDRFVLS
KGHGAPAIFQVLAEKNFFPVTDLNNFGKAGSLFHEHPPKPGLVPGIEAATGSLGHGLPMALGMALASRILKLNFRCYAML
SDGECNEGSIWEAAMMAASQKVENLIVIIDFNKWQATGRSKDILALDPLREKWSSFGWHTQEIDGHDFSQINDAFIEARK
IKSKPKAIIANTIKGKGVSFMEDDNNWHYRVPNNTELENALQELDNIK
>Mature_288_residues
MHRLMKNLKKSFKEKYNEKELQKIATKLRKKIITTSHRAKIPHLGSCLSCIDLLTYLYWSELFINPSDPKHINRDRFVLS
KGHGAPAIFQVLAEKNFFPVTDLNNFGKAGSLFHEHPPKPGLVPGIEAATGSLGHGLPMALGMALASRILKLNFRCYAML
SDGECNEGSIWEAAMMAASQKVENLIVIIDFNKWQATGRSKDILALDPLREKWSSFGWHTQEIDGHDFSQINDAFIEARK
IKSKPKAIIANTIKGKGVSFMEDDNNWHYRVPNNTELENALQELDNIK

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=280, Percent_Identity=36.0714285714286, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI4507521, Length=280, Percent_Identity=36.0714285714286, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI133778974, Length=265, Percent_Identity=35.4716981132075, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI225637459, Length=265, Percent_Identity=28.3018867924528, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI225637461, Length=265, Percent_Identity=27.5471698113208, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI225637463, Length=160, Percent_Identity=34.375, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI48994911, Length=248, Percent_Identity=32.258064516129, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788808, Length=248, Percent_Identity=31.0483870967742, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=262, Percent_Identity=35.4961832061069, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=252, Percent_Identity=30.952380952381, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319593, Length=252, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551847, Length=257, Percent_Identity=37.3540856031128, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45550715, Length=257, Percent_Identity=37.3540856031128, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24666278, Length=268, Percent_Identity=35.8208955223881, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24645119, Length=217, Percent_Identity=38.7096774193548, Blast_Score=158, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32557; Mature: 32557

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRLMKNLKKSFKEKYNEKELQKIATKLRKKIITTSHRAKIPHLGSCLSCIDLLTYLYWS
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHH
ELFINPSDPKHINRDRFVLSKGHGAPAIFQVLAEKNFFPVTDLNNFGKAGSLFHEHPPKP
HHEECCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCC
GLVPGIEAATGSLGHGLPMALGMALASRILKLNFRCYAMLSDGECNEGSIWEAAMMAASQ
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHH
KVENLIVIIDFNKWQATGRSKDILALDPLREKWSSFGWHTQEIDGHDFSQINDAFIEARK
HHCEEEEEEECCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
IKSKPKAIIANTIKGKGVSFMEDDNNWHYRVPNNTELENALQELDNIK
HHCCCHHEEHHCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHRLMKNLKKSFKEKYNEKELQKIATKLRKKIITTSHRAKIPHLGSCLSCIDLLTYLYWS
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHH
ELFINPSDPKHINRDRFVLSKGHGAPAIFQVLAEKNFFPVTDLNNFGKAGSLFHEHPPKP
HHEECCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCC
GLVPGIEAATGSLGHGLPMALGMALASRILKLNFRCYAMLSDGECNEGSIWEAAMMAASQ
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHH
KVENLIVIIDFNKWQATGRSKDILALDPLREKWSSFGWHTQEIDGHDFSQINDAFIEARK
HHCEEEEEEECCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
IKSKPKAIIANTIKGKGVSFMEDDNNWHYRVPNNTELENALQELDNIK
HHCCCHHEEHHCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]