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The map label for this gene is dxr [H]

Identifier: 123968850

GI number: 123968850

Start: 1095876

End: 1097090

Strand: Direct

Name: dxr [H]

Synonym: A9601_13171

Alternate gene names: 123968850

Gene position: 1095876-1097090 (Clockwise)

Preceding gene: 123968849

Following gene: 123968851

Centisome position: 65.63

GC content: 35.14

Gene sequence:

>1215_bases
GTGCTCGGTTCTACTGGTTCAATAGGGACTCAAACTCTCGAAATAGCTAGTGAGCAGCCTGATAAGTTTAAAGCGGTAGC
TCTTTCTGCAGGAAGAAATATTAATTTATTAACTGAACAAGTTAAAACACATAAACCAGAGGTAGTTGCAATTGAGGATG
AAAATCTTGTAGAAGATTTAAAAGATAATATTAATAACTTAGATTTGGATAATGCTACCTTAGTTTTGGGTGGGAAAGAG
GGAATTAACGCAGTTGCAGCATGGGATAAGGCAGATACTGTGGTAACTGGGATAGTAGGCTGTGCAGGCTTAATTCCAAC
AATGTCAGCAATTAATGCTGGGAAAAATATTGCACTTGCTAACAAAGAAACTTTAATTGCGGCAGGGCCAATTGTTATTC
CTGCATTAAAGAAAAATAATAGTAGGCTGTTACCTGCTGATTCAGAACACTCTGCTATCTTTCAATGTTTACAAGGATTA
CCTAATTATAAAAATGCAGATTTTTCAACAGGAGAGATGCCTAAGGGTTTAAAAGCCATACATTTAACAGCTTCTGGTGG
TGCTTTTAGAGATTGGGCCGTTGAGGATTTAAAGCATGTCACAGTGGAAGATGCGACTTCACATCCTAATTGGGATATGG
GGAAAAAAATAACTGTAGATTCTGCAACTCTTATGAATAAAGGATTAGAAGTTATTGAAGCTCATTATTTATTTGGGACC
TCTTACGAAAATATCGAAATAGTTATCCACCCTCAAAGTATTATTCATTCAATGATTGAGATGGAGGATTCTTCAGTATT
AGCTCAATTAGGTTGGCCAGATATGAAGCTACCTATTTTATATGCGATGAGTTGGCCTGAAAGATTTAAAACAAATTGGA
AAAGATTAAACCTAAGTGAAATTGGAAAATTAACTTTTAAAGAGCCAGACGAGTTTAAATATCCATGTATGGGACTTGCC
TATGCCGCAGGAAAATCTTCTGGAACTATGCCTGCTGTCTTAAATGCTGCTAATGAAATGGCTGTTGAACAATTCCTAAA
ACAAAAAATTTCTTTTCAAGAAATTCCTACATTTATAAGTAAAGCTTGTGAATCACATTTGGAGAATTTGAATTTAAGTC
CAGAATTAGAAGATATTCTTGAAGTAGACAATTGGGCCAGGCTTTTTGTTAAGCAAGAAATTAAAAAAGGGAAAAAATAC
GTAAATATTGGCTAA

Upstream 100 bases:

>100_bases
TAAATTTTAAGAAAAAAACCAATTTGAAATTTTTGTTTTTTAAATACACCTTTAAATGGGAAGATATTAGAAATATCAGA
GAAAATTGAAATACATTACT

Downstream 100 bases:

>100_bases
AAGTGAATATTAAAAAGCATCTTCTACTGTGCGCAACACCTACAAAACAGAAATGCTTTAAAGGCAATGAAGGACAAAAA
ACATGGGAATGTCTGAAAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDENLVEDLKDNINNLDLDNATLVLGGKE
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYKNADFSTGEMPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKQKISFQEIPTFISKACESHLENLNLSPELEDILEVDNWARLFVKQEIKKGKKY
VNIG

Sequences:

>Translated_404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDENLVEDLKDNINNLDLDNATLVLGGKE
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYKNADFSTGEMPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKQKISFQEIPTFISKACESHLENLNLSPELEDILEVDNWARLFVKQEIKKGKKY
VNIG
>Mature_404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDENLVEDLKDNINNLDLDNATLVLGGKE
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYKNADFSTGEMPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKQKISFQEIPTFISKACESHLENLNLSPELEDILEVDNWARLFVKQEIKKGKKY
VNIG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=43.4673366834171, Blast_Score=314, Evalue=7e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 44216; Mature: 44216

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDENLVEDL
CCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHH
KDNINNLDLDNATLVLGGKEGINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALA
HHCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYKNADFSTGEMPKGLKAI
CCCEEEEECCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
HLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
EEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEHHEECC
SYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSE
CCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCHHHHCCHHEECHHH
IGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKQKISFQEIPTFIS
HCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KACESHLENLNLSPELEDILEVDNWARLFVKQEIKKGKKYVNIG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDENLVEDL
CCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEECCCHHHHHH
KDNINNLDLDNATLVLGGKEGINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALA
HHCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYKNADFSTGEMPKGLKAI
CCCEEEEECCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
HLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
EEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEHHEECC
SYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSE
CCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCHHHHCCHHEECHHH
IGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKQKISFQEIPTFIS
HCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KACESHLENLNLSPELEDILEVDNWARLFVKQEIKKGKKYVNIG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA