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The map label for this gene is folP [H]

Identifier: 123968573

GI number: 123968573

Start: 902600

End: 903385

Strand: Reverse

Name: folP [H]

Synonym: A9601_10401

Alternate gene names: 123968573

Gene position: 903385-902600 (Counterclockwise)

Preceding gene: 123968574

Following gene: 123968571

Centisome position: 54.1

GC content: 30.66

Gene sequence:

>786_bases
ATGGGAGTTATTAATTTAACTCCTGATTCATTTAGTGATGGTGGGGAATTAAACTCTTCAAAAAAAGTTTTAGATCAAGT
AAACCATTTCTTGAGCAATGGTGTTGATGTTATTGATCTTGGTGCTCAAAGTACGAGACCTGGGGCTGAAGAAGTAGGAT
CTAGTATAGAAATTAAAAGATTGATCCCATATCTAAAATTAATAAAATCTGAATTTCCAGATGTTTTAATTTCTATTGAT
ACTTTTAATTCTGAAGTGGCTTACGAAGCTCTTTTAAATGGTGCTAACTGGATAAATGATGTCACGGGAGGAAGAAGAGA
TATAAAAATTTTGGATGTTGTATCAAAATTCAATTGTCCATTCGTCATAACTCATAGTCGTGGTAATAGTCAAAATATGA
ATCAACTCTCTAATTACCAGAATGTATTGAGTGATGTTAAGTGCTCGCTTGATAATTTAATAAAGAATGCTTTAGAAAAA
AATATATCTGAGAGAAATATAATAGTGGATCCTGGAATTGGTTTTTCAAAAGATATCATTCATAATTTGGAAATCTTGAG
AAATTTAGATGCATTTAAAAAATGGAATTTGCCAATTTTGATAGGTGCATCTAGGAAGAGATTTATAGGAGAAATTTTGA
ATGAGAAAATTCCAAAAGAAAGGGATATAGGAACTCTTGCAATAAGTTGTATTTGTTCTCAATTTAATGTTGACATTGTG
AGGGTTCACAACGTCAAGCTAAATTATCAAATCCTGAAAGTAGCTGATAGGATTTACAGAAAATAA

Upstream 100 bases:

>100_bases
GTTGGGGGGGCTTCATTAGATCCAAATAGTTTTGCGAGAATTGCAAATTATCAATAAGAAAAATCCATGGCCAAAAGGCT
GGGGCCAAAAAACTTCAATA

Downstream 100 bases:

>100_bases
TAAATTTATTATTCTTTAACTCCCTCGATTTTATCCTCTACCTCTTGGTATAGTTCTTTCAACTGTTCTATATTCTCATC
TGAAGTTTCCCAATATCCCC

Product: putative dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGVINLTPDSFSDGGELNSSKKVLDQVNHFLSNGVDVIDLGAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEFPDVLISID
TFNSEVAYEALLNGANWINDVTGGRRDIKILDVVSKFNCPFVITHSRGNSQNMNQLSNYQNVLSDVKCSLDNLIKNALEK
NISERNIIVDPGIGFSKDIIHNLEILRNLDAFKKWNLPILIGASRKRFIGEILNEKIPKERDIGTLAISCICSQFNVDIV
RVHNVKLNYQILKVADRIYRK

Sequences:

>Translated_261_residues
MGVINLTPDSFSDGGELNSSKKVLDQVNHFLSNGVDVIDLGAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEFPDVLISID
TFNSEVAYEALLNGANWINDVTGGRRDIKILDVVSKFNCPFVITHSRGNSQNMNQLSNYQNVLSDVKCSLDNLIKNALEK
NISERNIIVDPGIGFSKDIIHNLEILRNLDAFKKWNLPILIGASRKRFIGEILNEKIPKERDIGTLAISCICSQFNVDIV
RVHNVKLNYQILKVADRIYRK
>Mature_260_residues
GVINLTPDSFSDGGELNSSKKVLDQVNHFLSNGVDVIDLGAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEFPDVLISIDT
FNSEVAYEALLNGANWINDVTGGRRDIKILDVVSKFNCPFVITHSRGNSQNMNQLSNYQNVLSDVKCSLDNLIKNALEKN
ISERNIIVDPGIGFSKDIIHNLEILRNLDAFKKWNLPILIGASRKRFIGEILNEKIPKERDIGTLAISCICSQFNVDIVR
VHNVKLNYQILKVADRIYRK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=256, Percent_Identity=36.71875, Blast_Score=178, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29223; Mature: 29092

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVINLTPDSFSDGGELNSSKKVLDQVNHFLSNGVDVIDLGAQSTRPGAEEVGSSIEIKR
CCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCHHHH
LIPYLKLIKSEFPDVLISIDTFNSEVAYEALLNGANWINDVTGGRRDIKILDVVSKFNCP
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHCCCC
FVITHSRGNSQNMNQLSNYQNVLSDVKCSLDNLIKNALEKNISERNIIVDPGIGFSKDII
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHH
HNLEILRNLDAFKKWNLPILIGASRKRFIGEILNEKIPKERDIGTLAISCICSQFNVDIV
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEE
RVHNVKLNYQILKVADRIYRK
EEEEEEECHHHHHHHHHHHCC
>Mature Secondary Structure 
GVINLTPDSFSDGGELNSSKKVLDQVNHFLSNGVDVIDLGAQSTRPGAEEVGSSIEIKR
CEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCHHHH
LIPYLKLIKSEFPDVLISIDTFNSEVAYEALLNGANWINDVTGGRRDIKILDVVSKFNCP
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHCCCC
FVITHSRGNSQNMNQLSNYQNVLSDVKCSLDNLIKNALEKNISERNIIVDPGIGFSKDII
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHH
HNLEILRNLDAFKKWNLPILIGASRKRFIGEILNEKIPKERDIGTLAISCICSQFNVDIV
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEE
RVHNVKLNYQILKVADRIYRK
EEEEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]