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The map label for this gene is tpiA [H]

Identifier: 123968574

GI number: 123968574

Start: 903429

End: 904154

Strand: Reverse

Name: tpiA [H]

Synonym: A9601_10411

Alternate gene names: 123968574

Gene position: 904154-903429 (Counterclockwise)

Preceding gene: 123968575

Following gene: 123968573

Centisome position: 54.14

GC content: 32.78

Gene sequence:

>726_bases
TTGAGAAAATCTGTTATTGCTGGTAATTGGAAAATGCACATGACTTGTGCTGAGGCTAAGTCTTATTTAAAAGAGTTTAT
ACCTTTAATAAAAGATATAAATGAAGATCGTAAAGTAGTTATTGCTCCACCTTTTACTGCTATTTCAACCTTTTCTAATC
ATTCTGATTTTGATTATTTAGATATTTCTAGTCAAAATATTCATTGGGAAGATCAAGGAGCATTTACTGCTGAAATATCA
CCAAAAATGCTTCTTGAACATGGTGTCTCATATGCAATCGTTGGACATAGTGAACCAAGGAAATATTTTAGTGAAAGTGA
TGAACAAATTAATAAAAGAGCAGTTTTTGCTCAATCAAGTGGACTTACTCCAATAGTTTGTGTAGGAGAAACATTAGAAC
AAAGAGAGAGAGGAGAAGCTGTAAGAGTTATTACTAGACAAGTTGAACAAGGATTAGAAAACACAGATCCATCTAATTTA
ATTGTTGCCTATGAACCAATATGGGCTATTGGCACTGGTAAAACATGTCAGGCAGAAGATGCTAATAAGATATGTTCTTT
GATTCGGAAATTAATTGGTTTTGATGATGTAATTATTCAATATGGAGGATCCGTTAAACCTAATAATATTGACGAAATCA
TGTCAATGAGTGACATAGATGGGGTTTTAGTTGGGGGGGCTTCATTAGATCCAAATAGTTTTGCGAGAATTGCAAATTAT
CAATAA

Upstream 100 bases:

>100_bases
AAGGGAGATAAAGTTATATTTCTAAAAAATGAATTATTTTTTGAATAATTGGCCTATTAAACTCAATATATATTAATATG
ATTTTCTTGGAGATAGTATT

Downstream 100 bases:

>100_bases
GAAAAATCCATGGCCAAAAGGCTGGGGCCAAAAAACTTCAATAATGGGAGTTATTAATTTAACTCCTGATTCATTTAGTG
ATGGTGGGGAATTAAACTCT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYLDISSQNIHWEDQGAFTAEIS
PKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSSGLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNL
IVAYEPIWAIGTGKTCQAEDANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANY
Q

Sequences:

>Translated_241_residues
MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYLDISSQNIHWEDQGAFTAEIS
PKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSSGLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNL
IVAYEPIWAIGTGKTCQAEDANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANY
Q
>Mature_241_residues
MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYLDISSQNIHWEDQGAFTAEIS
PKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSSGLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNL
IVAYEPIWAIGTGKTCQAEDANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANY
Q

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=250, Percent_Identity=38.4, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=38.7096774193548, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=38.4, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17536593, Length=246, Percent_Identity=38.6178861788618, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320255, Length=248, Percent_Identity=36.6935483870968, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28572008, Length=246, Percent_Identity=39.4308943089431, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI28572006, Length=246, Percent_Identity=39.4308943089431, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI28572004, Length=238, Percent_Identity=39.4957983193277, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26748; Mature: 26748

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYL
CCCCEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCCCEE
DISSQNIHWEDQGAFTAEISPKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSS
ECCCCCCEECCCCCEEEECCHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHEEEECCC
GLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNLIVAYEPIWAIGTGKTCQAED
CCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCCCCCCC
ANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANY
HHHHHHHHHHHHCCCCEEHCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHCCC
Q
C
>Mature Secondary Structure
MRKSVIAGNWKMHMTCAEAKSYLKEFIPLIKDINEDRKVVIAPPFTAISTFSNHSDFDYL
CCCCEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCCCEE
DISSQNIHWEDQGAFTAEISPKMLLEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQSS
ECCCCCCEECCCCCEEEECCHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHEEEECCC
GLTPIVCVGETLEQRERGEAVRVITRQVEQGLENTDPSNLIVAYEPIWAIGTGKTCQAED
CCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCCCCCCC
ANKICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANY
HHHHHHHHHHHHCCCCEEHCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA