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The map label for this gene is fmt

Identifier: 123968561

GI number: 123968561

Start: 888480

End: 889466

Strand: Direct

Name: fmt

Synonym: A9601_10281

Alternate gene names: 123968561

Gene position: 888480-889466 (Clockwise)

Preceding gene: 123968560

Following gene: 123968563

Centisome position: 53.21

GC content: 30.9

Gene sequence:

>987_bases
GTGAGAATTATATTCTGGGGAACACCTGAATATTCAATTGCTAGCCTTGATATTTTTATTAAATCTAAGCACGAAGTAAT
TGGAGTAGTTAGCCAACCCGATAAGAAAAGATCTAGGGGAAATAAATTAATATCCTCTCCTGTTAAAAGCTTTGCCGAGC
AAGAATCTATAAAAATTTATACTCCAGTAAAAATCAGGGACAATATACATTTTATAAATGAACTTAAATCACTATCTTGT
GATTTATTTATTGTTATTGCTTACGGGAAAATATTACCAAAAGAGATATTAGAAATCCCAAAATTTGGATGCTGGAACGC
ACATGCTTCATTACTTCCAAGATGGCGAGGTGCAGCCCCAATCCAATGGTCGCTAATAAAGGGTGATAAATTTACTGGTG
TAGGAATTATGAAAATGAATGAGGGACTAGATACTGGCGACTTATTATTGGAAGAAAAAATTAAAATTGGTAATGAAGAT
AATTTAAATACACTATCGGAAAAACTTAGTATTTTGTCTGCAAAATTATTTTTAAAAGCCGCATCACTACTCGAAGAAAA
TTTTTATAAAAATACTAAATCTCAATTAACAAAACAAAATTCCCTTGGAAGAGAAATTACTTACGCAAGAATGATTGAAA
AATCAGACTTTAGAGTTGATTGGGGTAATCAGGCAATTGCTATTTCTCAAAAAATAAAAGGATTATACCCACGAGCAAAT
ACAATTTTTAGAGGTAAGAACCTAAAAATACTTAAAATCAAAGTTTTGAGTAGCGATGAAATTAAAAATGAAAAATACCT
TTTCATGAGCGATTATTCAAGACCAGGTATTATTCTTGCTGTAATAGAAGATGAAGGAATAATAATTTCAACTAAAACTG
ATCCGATTATATTGTTAGAAGCGAAACTTGAAGGCAAAAACATTTCTAGCAAAAAGCAATTGATACAACAGTTAAAGCCA
TCAGTAGGTGAATATCTCTCAGATTAA

Upstream 100 bases:

>100_bases
TTTTGAAGAATATATTAAATATTGAATCAAACCAGAAAGTAACAACAAGTGGAATTTCTCCACATATATGGGTAGATGAA
TTATCAATAACTGGTGACGC

Downstream 100 bases:

>100_bases
GTTTTTGATTATTTTTTAGAGAATCCCCAAATAAAAGCAAAAAGAATCAAAAAATAAAAATAATAGTCTGGAAGAATAGA
TTCTTTAACTAACGTATTTA

Product: putative methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPVKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDKFTGVGIMKMNEGLDTGDLLLEEKIKIGNED
NLNTLSEKLSILSAKLFLKAASLLEENFYKNTKSQLTKQNSLGREITYARMIEKSDFRVDWGNQAIAISQKIKGLYPRAN
TIFRGKNLKILKIKVLSSDEIKNEKYLFMSDYSRPGIILAVIEDEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SVGEYLSD

Sequences:

>Translated_328_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPVKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDKFTGVGIMKMNEGLDTGDLLLEEKIKIGNED
NLNTLSEKLSILSAKLFLKAASLLEENFYKNTKSQLTKQNSLGREITYARMIEKSDFRVDWGNQAIAISQKIKGLYPRAN
TIFRGKNLKILKIKVLSSDEIKNEKYLFMSDYSRPGIILAVIEDEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SVGEYLSD
>Mature_328_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPVKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDKFTGVGIMKMNEGLDTGDLLLEEKIKIGNED
NLNTLSEKLSILSAKLFLKAASLLEENFYKNTKSQLTKQNSLGREITYARMIEKSDFRVDWGNQAIAISQKIKGLYPRAN
TIFRGKNLKILKIKVLSSDEIKNEKYLFMSDYSRPGIILAVIEDEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SVGEYLSD

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=287, Percent_Identity=27.8745644599303, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI238814322, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI164663775, Length=280, Percent_Identity=24.6428571428571, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789683, Length=319, Percent_Identity=36.6771159874608, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1788589, Length=177, Percent_Identity=25.4237288135593, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133930964, Length=179, Percent_Identity=30.1675977653631, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550868, Length=311, Percent_Identity=27.9742765273312, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571984, Length=179, Percent_Identity=32.9608938547486, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585660, Length=176, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PROMS (A2BRA1)

Other databases:

- EMBL:   CP000551
- RefSeq:   YP_001009419.1
- ProteinModelPortal:   A2BRA1
- SMR:   A2BRA1
- STRING:   A2BRA1
- GeneID:   4717739
- GenomeReviews:   CP000551_GR
- KEGG:   pmb:A9601_10281
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   LEETING
- PhylomeDB:   A2BRA1
- ProtClustDB:   CLSK921992
- BioCyc:   PMAR146891:A9601_10281-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37091; Mature: 37091

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIY
CEEEEECCCCCEEEEEEEEEECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCCEEEE
TPVKIRDNIHFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
ECEEEECCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCC
IQWSLIKGDKFTGVGIMKMNEGLDTGDLLLEEKIKIGNEDNLNTLSEKLSILSAKLFLKA
EEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ASLLEENFYKNTKSQLTKQNSLGREITYARMIEKSDFRVDWGNQAIAISQKIKGLYPRAN
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCEEEEEHHHCCCCCCCC
TIFRGKNLKILKIKVLSSDEIKNEKYLFMSDYSRPGIILAVIEDEGIIISTKTDPIILLE
EEEECCCEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEE
AKLEGKNISSKKQLIQQLKPSVGEYLSD
EEECCCCCCHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIY
CEEEEECCCCCEEEEEEEEEECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCCEEEE
TPVKIRDNIHFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
ECEEEECCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCC
IQWSLIKGDKFTGVGIMKMNEGLDTGDLLLEEKIKIGNEDNLNTLSEKLSILSAKLFLKA
EEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ASLLEENFYKNTKSQLTKQNSLGREITYARMIEKSDFRVDWGNQAIAISQKIKGLYPRAN
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCEEEEEHHHCCCCCCCC
TIFRGKNLKILKIKVLSSDEIKNEKYLFMSDYSRPGIILAVIEDEGIIISTKTDPIILLE
EEEECCCEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEE
AKLEGKNISSKKQLIQQLKPSVGEYLSD
EEECCCCCCHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA