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The map label for this gene is purK [H]

Identifier: 123968273

GI number: 123968273

Start: 657471

End: 658661

Strand: Direct

Name: purK [H]

Synonym: A9601_07381

Alternate gene names: 123968273

Gene position: 657471-658661 (Clockwise)

Preceding gene: 123968271

Following gene: 123968274

Centisome position: 39.37

GC content: 31.23

Gene sequence:

>1191_bases
ATGAGTTTTAAAAAAAATATAAACGATATCAAGAAAAATTATTCCCTAGGAATAATTGGAGGTGGTCAACTGGCACTGAT
GTTAACCGAGGCAGCAAAAAAAAGAGATTTAGAAGTATGTGTGCAAACAAAATCTTGTGATGATCCTGCTGGCTCAAAAG
CAGATCATGTCATAGAAGCTGATCCTTTAAAGATAAGAGGAAATAAATCATTAATTAATGAGTGTGAAAAAATAATTTTT
GAAAATGAATGGATAAAAATTGATAAATTAAATTTAATTGGCAATGAAGATATTTTTGTTCCAAGCCTTAATGCAATTAA
GCCATTAGTAGATAGGTTTTCTCAAAAAAAATTAATAGATAGAATGAATATTCCCTGTCCAAAATGGATAAGTATTGAAG
ATTTTAAAAATCTCTCGGATGAGGAAATCAATAATTGGACTTTTCCTCTAATGGCAAAATCAAATAAAGGTGGATACGAC
GGCAAAGGGAACAGAAAAATAAAGACAAAAGAAGATTTAGATTCTTTTTTAACAGAGAATAATTCTGATGAATGGTTAAT
AGAAGAATGGATAGAGTATGAAAAAGAACTGGCTCTTGTTGGTTCGAGAGATAGGACCGGTAAGATAAGATTCTTTCCAA
TAGTTGAGACGTTCCAATCAAACCATGTTTGTGATTGGGTTCTTGCACCTGGATCAAATGAATATGATTTGAACTTATTT
GCAATAAATATTTTCTCTTCAATAGTCAATGAACTTAATTACGTTGGAGTTTTAGCTATTGAATTCTTCTATGGAGATAA
TGGTCTTTTAATTAATGAAATAGCTCCTAGAACACATAACTCAGCTCATTTCTCTATTGAAGCTTGCACATCAAGTCAGT
TTGATCAATATGTTTGCATTTCTTCTGGGATAATACCACCTGAAATTAAAATGAACTGTGAAGGTGCAATTATGATAAAT
CTACTGGGGTTAAAAAAGAATTTCCCAATCTCAATGGAAACCAGAATTAAAATGTTATCTGAAATTGAGGGTTCTAATAT
TCATTGTTATGGCAAATCTCGCGAAATTCTTGGACGAAAAATGGCTCACATCACATTTTTATTAAATGGTAAAACGCATT
CAGAAAGATATGATGAAGCTCAAATTTTATTAACTATGGTAAGAGACATTTGGCCATCTCCAAATGCATAA

Upstream 100 bases:

>100_bases
TAAATATTTGTATTAAGTATTTTATATATTAGCAAAATCTAAGCTCTAGATCCTTAAAAATTCAGTTGTTAAGAATTAGA
AATGGTAATAAAATCATGCT

Downstream 100 bases:

>100_bases
AAAAATAAGTTAGAGTTAGATTACTGGATCTTTGGTTAAGTTCTTCTTTATGTGCTCTGATCTGACTCTCTTTCGACATG
AGGAGACTGTCGTGATGCGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSFKKNINDIKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGSKADHVIEADPLKIRGNKSLINECEKIIF
ENEWIKIDKLNLIGNEDIFVPSLNAIKPLVDRFSQKKLIDRMNIPCPKWISIEDFKNLSDEEINNWTFPLMAKSNKGGYD
GKGNRKIKTKEDLDSFLTENNSDEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGSNEYDLNLF
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIIPPEIKMNCEGAIMIN
LLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHSERYDEAQILLTMVRDIWPSPNA

Sequences:

>Translated_396_residues
MSFKKNINDIKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGSKADHVIEADPLKIRGNKSLINECEKIIF
ENEWIKIDKLNLIGNEDIFVPSLNAIKPLVDRFSQKKLIDRMNIPCPKWISIEDFKNLSDEEINNWTFPLMAKSNKGGYD
GKGNRKIKTKEDLDSFLTENNSDEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGSNEYDLNLF
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIIPPEIKMNCEGAIMIN
LLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHSERYDEAQILLTMVRDIWPSPNA
>Mature_395_residues
SFKKNINDIKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGSKADHVIEADPLKIRGNKSLINECEKIIFE
NEWIKIDKLNLIGNEDIFVPSLNAIKPLVDRFSQKKLIDRMNIPCPKWISIEDFKNLSDEEINNWTFPLMAKSNKGGYDG
KGNRKIKTKEDLDSFLTENNSDEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGSNEYDLNLFA
INIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIIPPEIKMNCEGAIMINL
LGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHSERYDEAQILLTMVRDIWPSPNA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=358, Percent_Identity=25.9776536312849, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=377, Percent_Identity=30.2387267904509, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 44969; Mature: 44838

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKKNINDIKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGSKADHVIEA
CCCCCCHHHHHHCCEEEEEECCEEEEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCEEEC
DPLKIRGNKSLINECEKIIFENEWIKIDKLNLIGNEDIFVPSLNAIKPLVDRFSQKKLID
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
RMNIPCPKWISIEDFKNLSDEEINNWTFPLMAKSNKGGYDGKGNRKIKTKEDLDSFLTEN
HCCCCCCCCEEHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
NSDEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGSNEYDLNLF
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCEEEEEE
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCI
EHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGIIPPEIKMNCEGAIMINLLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRK
ECCCCCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHE
MAHITFLLNGKTHSERYDEAQILLTMVRDIWPSPNA
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFKKNINDIKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGSKADHVIEA
CCCCCHHHHHHCCEEEEEECCEEEEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCEEEC
DPLKIRGNKSLINECEKIIFENEWIKIDKLNLIGNEDIFVPSLNAIKPLVDRFSQKKLID
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
RMNIPCPKWISIEDFKNLSDEEINNWTFPLMAKSNKGGYDGKGNRKIKTKEDLDSFLTEN
HCCCCCCCCEEHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
NSDEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGSNEYDLNLF
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCEEEEEE
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCI
EHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGIIPPEIKMNCEGAIMINLLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRK
ECCCCCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHE
MAHITFLLNGKTHSERYDEAQILLTMVRDIWPSPNA
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA