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The map label for this gene is hisS [H]

Identifier: 123968214

GI number: 123968214

Start: 603778

End: 605058

Strand: Direct

Name: hisS [H]

Synonym: A9601_06791

Alternate gene names: 123968214

Gene position: 603778-605058 (Clockwise)

Preceding gene: 123968212

Following gene: 123968215

Centisome position: 36.16

GC content: 32.16

Gene sequence:

>1281_bases
TTGAATAACTTAAAAAACCTAAGAGGAACAGTAGACCTATTTCCTGATCAATTAATAAAGTGGCAAAACGTTGAAAAAAT
TTTATTAGAGCAGCTCTCTAGAGCATCCATCAAAGAAATAAGAACACCAATATTGGAAATGACCGAATTATTTATAAGAG
GAATTGGTGAAGGAACAGATGTTGTCAGTAAGGAAATGTATACATTTCTTGATAGGGGGGAGAGGTCTTGCACTCTAAGA
CCTGAAGGAACAGCCTCAGTCGCACGAGCGTTAATACAAAACGGAATATCTTCTAATCCTATTCAAAAACTTTGGTACAT
GGGTCCTATGTTTCGATACGAAAGACCTCAAGCTGGCAGGCAAAGACAGTTTCATCAATTAGGTGTTGAGTTTATAGGAC
ATGATTCAGTTAGAAGTGATGTTGAAATTATTGCTTTAGCTTGGGATATATTACGCAAATTAGGAATAAAAGAACTCAAT
CTTGAAATAAATACGTTAGGTGATACTAATGACAGATCAAATTTTCAAAAATCTTTTTTAAAATGGTTAGAAACAAATAA
AGATTCTCTAGATTTAGATTCTCAGAATAGAATTTCTAAAAACCCTTTGAGGATTTTGGACTCAAAGAATATTCAAACTA
AAAAAGTTCTTGAAAATGCACCAAGATTATTTAATTTTTTATCTGAAAAAAGTCATAACAGATATTTAGACTTAAAAAGA
CAATTAGAGGTTTTAAAAATACCTTATGTAGAAAATTTTAATCTTGTAAGAGGTTTAGATTACTACACTCATACAGCTTT
TGAAATTACTAGTGGGGCTTTGGGCTCCCAAGCTACAGTTTGCGGAGGAGGGAGATACGACGATTTAATAAAACAAATGG
GAGGGCCAAACACTCCTGCAATTGGTTTCGCTATTGGTTTAGAAAGATTAATTTTACTCGCAGGAAAAGAGCTTGAAATT
CCAAGAAATACTGATATCTATATCATTAATAAAGGCTTAGTTGCTGAATCATTAGCAATGGATTTATCAAGAAAATTAAG
AAATTACGATTTGTTAGTTGAGTTAGATTTAAGCGGAGCCTCATTCTCTAAGCAATTTAAAAAGGCAAATAAACTTAAAT
CTAAAAGTATTATTGTTATTGGTGAGGATGAGGCAGTTAATGGGGAATTTATTATAAGGCTCTTTGATCAATCGGGTAAT
GGGAATGAAGAGGAGGTTATATCTTTTGAGAATGATATTAAATTAGAAAATTGGATAAACAATAACTTACTTGTAAAGTG
A

Upstream 100 bases:

>100_bases
AATAGTTTTTCTAAATGTTAAATTAAAATTGTCTCACAAAATAACCAATCAAAGATTAATTTCTAGATGAATTAAAAATT
TTGAATTATTTTTTAGAACT

Downstream 100 bases:

>100_bases
TGTTCTTGAAAATAGTGATAATTTTTCTTTTTATAATTATTTCTTTTAATTTAAGGAATTTTCTTAAATTAAATAGAAAA
CAAAAAGTTTTTAATTCTAA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNNLKNLRGTVDLFPDQLIKWQNVEKILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPIQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILRKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLETNKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLFNFLSEKSHNRYLDLKR
QLEVLKIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLVAESLAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGEDEAVNGEFIIRLFDQSGN
GNEEEVISFENDIKLENWINNNLLVK

Sequences:

>Translated_426_residues
MNNLKNLRGTVDLFPDQLIKWQNVEKILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPIQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILRKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLETNKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLFNFLSEKSHNRYLDLKR
QLEVLKIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLVAESLAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGEDEAVNGEFIIRLFDQSGN
GNEEEVISFENDIKLENWINNNLLVK
>Mature_426_residues
MNNLKNLRGTVDLFPDQLIKWQNVEKILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPIQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILRKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLETNKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLFNFLSEKSHNRYLDLKR
QLEVLKIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLVAESLAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGEDEAVNGEFIIRLFDQSGN
GNEEEVISFENDIKLENWINNNLLVK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=397, Percent_Identity=46.095717884131, Blast_Score=350, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6325290, Length=479, Percent_Identity=22.5469728601253, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48497; Mature: 48497

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKNLRGTVDLFPDQLIKWQNVEKILLEQLSRASIKEIRTPILEMTELFIRGIGEGTD
CCCHHHHCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARALIQNGISSNPIQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGHDSVRSDVEIIALAWDILRKLGIKELNLEINTLGDTNDRSNFQKSFL
HHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHH
KWLETNKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLFNFLSEKSHNRYLDLKR
HHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QLEVLKIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPA
CHHHEECCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKELEIPRNTDIYIINKGLVAESLAMDLSRKLRNYDLLVELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIVIGEDEAVNGEFIIRLFDQSGNGNEEEVISFENDIKLENWIN
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHEEECCCCCCHHHHCC
NNLLVK
CCCEEC
>Mature Secondary Structure
MNNLKNLRGTVDLFPDQLIKWQNVEKILLEQLSRASIKEIRTPILEMTELFIRGIGEGTD
CCCHHHHCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARALIQNGISSNPIQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGHDSVRSDVEIIALAWDILRKLGIKELNLEINTLGDTNDRSNFQKSFL
HHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHH
KWLETNKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLFNFLSEKSHNRYLDLKR
HHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QLEVLKIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPA
CHHHEECCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKELEIPRNTDIYIINKGLVAESLAMDLSRKLRNYDLLVELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIVIGEDEAVNGEFIIRLFDQSGNGNEEEVISFENDIKLENWIN
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHEEECCCCCCHHHHCC
NNLLVK
CCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA