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The map label for this gene is menB [H]

Identifier: 123968199

GI number: 123968199

Start: 587610

End: 588467

Strand: Direct

Name: menB [H]

Synonym: A9601_06641

Alternate gene names: 123968199

Gene position: 587610-588467 (Clockwise)

Preceding gene: 123968198

Following gene: 123968200

Centisome position: 35.19

GC content: 36.83

Gene sequence:

>858_bases
ATGAAAGTATTACCTGGTAAAACAAATTTAAATTGGTCAGAATGCAAATCTTATGAGGATATATTGTTTCATAAATCTGA
TGAGGGAATTGCGAGAATTGCAATCAATCGGCCTGAAAAAAGAAATGCATTTAGGCCACAAACTGTAGATGAACTTATCA
ATGCATTTAATATCGTAAGAAATGATGAAACTATTGGCGTAGTTCTCTTTACAGGTGCGGGACCTGACAAGAAAGGTATT
TATTCTTTTTGCTCTGGAGGTGATCAGAGCGTAAGAGGTGAAAATGGATACAAAAATTATGAAGGGAAGCAGAGATTAAA
TGTACTTGAACTTCAAAGATTAATAAGAAGTTTGCCTAAAGTGGTTATTGCCTTAGTCCCTGGTTTCGCAATTGGAGGAG
GCCAGGTGCTTCATTTGATTTGTGATCTAAGTATCGCCTCTGAAAATGCAATATTTGGTCAAACAGGTCCCAGAGTTGGT
AGTTTTGATGCTGGATTTGGATCTAGTTATTTGGCAAGACTTGTTGGTCAAAGAAAAGCAAAAGAAATTTGGTTTTTATG
TAGAAAATATAATTCTGAGGAAGCACTCGAGATGGGCTTGATAAATGCAATTACAAAGATTGAAGAATTAGAAGCTGAGG
GTGTAATCTGGGCAAGAGAGATATTACGAAATAGTCCAACTGCTATTCGTATTCTTAAAGCTTCATTCAATGCTGAGAAT
GATGGGATTGCAGGTATTCAAGAATTATCTGGATACACAACTCAATTATTTTATTCCACTGAAGAAGCCCAAGAAGGTAG
AGATGCCTTTCTTGAAAAGCGTCCTCCAGACTTCTCTGACTACAAGTGGACACCCTAA

Upstream 100 bases:

>100_bases
ATATTGATCCACAAAATGAAATTTGTGAAAAAAATTCTCTGCTAGAAAAAATAATTGGCAGTTAAATTTATGATTTTTTA
TCTTTGAATAATTAGAATTC

Downstream 100 bases:

>100_bases
TTTATTTTTCAAAAGAACTTTATTAAATAATTATCAATGAGAATTCTTCTTGCCGCTGCCGAATGTGCTCCAATGATCAA
AGTTGGAGGTATGGGAGATG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKVLPGKTNLNWSECKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNYEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSEEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTEEAQEGRDAFLEKRPPDFSDYKWTP

Sequences:

>Translated_285_residues
MKVLPGKTNLNWSECKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNYEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSEEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTEEAQEGRDAFLEKRPPDFSDYKWTP
>Mature_285_residues
MKVLPGKTNLNWSECKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDETIGVVLFTGAGPDKKGI
YSFCSGGDQSVRGENGYKNYEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSEEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSTEEAQEGRDAFLEKRPPDFSDYKWTP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=273, Percent_Identity=29.6703296703297, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502327, Length=276, Percent_Identity=28.9855072463768, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=27.3972602739726, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=27.3972602739726, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=28.310502283105, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757966, Length=228, Percent_Identity=27.1929824561404, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI51538581, Length=228, Percent_Identity=27.1929824561404, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI25453481, Length=228, Percent_Identity=27.1929824561404, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI51538573, Length=228, Percent_Identity=27.1929824561404, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI70995211, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=278, Percent_Identity=58.6330935251799, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=28.2868525896414, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787660, Length=268, Percent_Identity=29.1044776119403, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI221142681, Length=266, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=263, Percent_Identity=31.5589353612167, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=255, Percent_Identity=28.6274509803922, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=214, Percent_Identity=29.4392523364486, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=209, Percent_Identity=27.7511961722488, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=185, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=266, Percent_Identity=25.5639097744361, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653139, Length=284, Percent_Identity=29.9295774647887, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI20129971, Length=276, Percent_Identity=28.6231884057971, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653477, Length=276, Percent_Identity=28.6231884057971, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357171, Length=199, Percent_Identity=30.6532663316583, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654903, Length=186, Percent_Identity=31.7204301075269, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24650670, Length=181, Percent_Identity=29.8342541436464, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31732; Mature: 31732

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLPGKTNLNWSECKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVR
CCCCCCCCCCCHHHHCCHHHHHEECCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHC
NDETIGVVLFTGAGPDKKGIYSFCSGGDQSVRGENGYKNYEGKQRLNVLELQRLIRSLPK
CCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLICDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSEEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSTEEAQEGRDAFLEKRPPDFSDYKWTP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKVLPGKTNLNWSECKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVR
CCCCCCCCCCCHHHHCCHHHHHEECCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHC
NDETIGVVLFTGAGPDKKGIYSFCSGGDQSVRGENGYKNYEGKQRLNVLELQRLIRSLPK
CCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLICDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSEEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSTEEAQEGRDAFLEKRPPDFSDYKWTP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]