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The map label for this gene is gor [H]

Identifier: 123968158

GI number: 123968158

Start: 544450

End: 545814

Strand: Direct

Name: gor [H]

Synonym: A9601_06231

Alternate gene names: 123968158

Gene position: 544450-545814 (Clockwise)

Preceding gene: 123968156

Following gene: 123968160

Centisome position: 32.6

GC content: 30.33

Gene sequence:

>1365_bases
TTGGAATTTGAATTTGATTTAATTGTTGTTGGCGCTGGATCTGGAGGACTCGCAGCGGCTAAACGTGCGGCTAGTTATGG
AGCAAAAGTCGCAATCATAGAAGCAAATCAAATAGGAGGAACTTGTGTGATAAGGGGATGTGTGCCCAAGAAATTAATGG
TTTATGCAGCTAAAAGTAAAAAAAATATGGATTCTTCTGAAGGATATGGATTAAAAAATGAAGGTATTAATTTTGAATCA
AATATTTTGTTGAAGAATGTTAGAGAGGAGGTTTCTAGATTAAGTAATTTACATAGAAGTTCTTTAAAAAAGTTGAATAT
AACTATTTTTGAAGGCTTAGGAAGATTTATTACTCAAAATGAATTAGAAATTATTTGTTCAAACACAAAGAAAATTAAAA
ATAAAATAAGTTCAAAAAAAATTCTTATTTCAGTTGGAGGTAAACCAAAGAAATTAAATATTCCTGGGGTTGATTTGGCA
TGGACTAGTGATGATATATTTGAATTAGAAAAGTTTCCTAAATCAATATTAATAGTAGGAGGGGGATATATTGCTTGTGA
ATTTGCTTCTATTTTCAGGAATTTAGGTACTGAAGTAACTCAATTAATTAGAGGTCAACATTTACTTAATGGTTTTGATG
AGGATCTTTCTTCATGCCTAGAGGAATCACCTACTTTTGCTGATATCAATATAATCCCCAATACTCAATTAAATTCTATC
AAAAAAGTAAATGGAAATCTGGAATCTACCTTAGACTCGGGAGATAAACTCCTAACTAATAATATTCTTATTGCTACAGG
AAGAGAACCAAATCTTTTGCCTTTAAATTTAGATTTTTTAAATCTAAAGATGGATGGCCAATATTTAGATGTCGATGAAC
TTAATCAAACAAGCAACGCAAATATTTTTGCAGTTGGCGATATTATAAATAAGCCAAACTTAACTCCAGTAGCAATAGAA
CAAGGGAGAGTTTTTTCGGATAATTTTTTTAATGACCAAAAAAGAAAAGTGAATTATGAATATATCCCTAAGGCCGTTTT
TACTATTCCAGAAATTTCAACAGTTGGCTTAAGTGAGAAAAGAGCTAAAGAGATTTACTCTGAAAAAAATATAAAAATTT
TCAAATGCAAATTTACCCCTATGTCTAATACCTTTAAAAAGAATAAATCAAAATGTATGTTGAAGATTGTAGTTCATAAG
CTAACTGACAAAGTCCTAGGATGTCATATGTTTGGAGAAACATCGTCTGAGATTATTCAAATGGTATCAATTTCATTAAA
TGCAGGGATAACAAAAAAAGACTTTGATATTACTATGGCTTTGCATCCAACTATCTCAGAAGAATTTGTGACTATGTATG
GATAA

Upstream 100 bases:

>100_bases
TTCGACTTCAAATTTATTTAAATCATCCCATGTCAAAATCCCATTCATTATTTGAATTAAAGCTATAAACTAACGTTATA
ATAATTGATTAAAAAAAGTC

Downstream 100 bases:

>100_bases
AATTATGAATTAGAAAATTTTAATTTTTCTTGAAGAATCAGAAATGTTATAAGTAATGCAAAGTAAATAAATAAACCTAT
CCTTAATTCAGAAAGGAAGT

Product: glutathione reductase (NADPH)

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRSSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGVDLA
WTSDDIFELEKFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQHLLNGFDEDLSSCLEESPTFADINIIPNTQLNSI
KKVNGNLESTLDSGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSISLNAGITKKDFDITMALHPTISEEFVTMYG

Sequences:

>Translated_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRSSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGVDLA
WTSDDIFELEKFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQHLLNGFDEDLSSCLEESPTFADINIIPNTQLNSI
KKVNGNLESTLDSGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSISLNAGITKKDFDITMALHPTISEEFVTMYG
>Mature_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRSSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGVDLA
WTSDDIFELEKFPKSILIVGGGYIACEFASIFRNLGTEVTQLIRGQHLLNGFDEDLSSCLEESPTFADINIIPNTQLNSI
KKVNGNLESTLDSGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSISLNAGITKKDFDITMALHPTISEEFVTMYG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=36.7965367965368, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=31.7894736842105, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=31.7894736842105, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=31.7894736842105, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=30.4157549234136, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=31.3684210526316, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=30.8176100628931, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=29.0393013100437, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI291045268, Length=477, Percent_Identity=28.3018867924528, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=26.9067796610169, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=35.0797266514806, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=28.0087527352298, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=26.8398268398268, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=26.0393873085339, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=35.9574468085106, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI71983429, Length=460, Percent_Identity=37.3913043478261, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983419, Length=460, Percent_Identity=37.3913043478261, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=32.2245322245322, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=26.6811279826464, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=36.0341151385927, Blast_Score=269, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=23.6051502145923, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=24.8394004282655, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=32.8421052631579, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=32.2784810126582, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=32.2784810126582, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=32.2784810126582, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=26.8817204301075, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50231; Mature: 50231

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSK
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCC
KNMDSSEGYGLKNEGINFESNILLKNVREEVSRLSNLHRSSLKKLNITIFEGLGRFITQN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHCCC
ELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGVDLAWTSDDIFELEKFPKSILIVG
CEEEEECCHHHHHHHCCCCEEEEEECCCCCEECCCCCEEEECCCHHHHHHHCCCEEEEEE
GGYIACEFASIFRNLGTEVTQLIRGQHLLNGFDEDLSSCLEESPTFADINIIPNTQLNSI
CCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHH
KKVNGNLESTLDSGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNA
HHHCCCHHHHHCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCCCCCCC
NIFAVGDIINKPNLTPVAIEQGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEK
CEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHCCCHHHCCCEEEECCCCEECCCCHH
RAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHKLTDKVLGCHMFGETSSEIIQ
HHHHHHCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHH
MVSISLNAGITKKDFDITMALHPTISEEFVTMYG
HHHHHCCCCCEECCCEEEEEECCCCCCCHHEECC
>Mature Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSK
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCC
KNMDSSEGYGLKNEGINFESNILLKNVREEVSRLSNLHRSSLKKLNITIFEGLGRFITQN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHCCC
ELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGVDLAWTSDDIFELEKFPKSILIVG
CEEEEECCHHHHHHHCCCCEEEEEECCCCCEECCCCCEEEECCCHHHHHHHCCCEEEEEE
GGYIACEFASIFRNLGTEVTQLIRGQHLLNGFDEDLSSCLEESPTFADINIIPNTQLNSI
CCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHH
KKVNGNLESTLDSGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNA
HHHCCCHHHHHCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCCCCCCC
NIFAVGDIINKPNLTPVAIEQGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEK
CEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHCCCHHHCCCEEEECCCCEECCCCHH
RAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHKLTDKVLGCHMFGETSSEIIQ
HHHHHHCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHH
MVSISLNAGITKKDFDITMALHPTISEEFVTMYG
HHHHHCCCCCEECCCEEEEEECCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]