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The map label for this gene is mutM [H]

Identifier: 123967891

GI number: 123967891

Start: 328123

End: 329001

Strand: Reverse

Name: mutM [H]

Synonym: A9601_03541

Alternate gene names: 123967891

Gene position: 329001-328123 (Counterclockwise)

Preceding gene: 123967892

Following gene: 123967889

Centisome position: 19.7

GC content: 31.06

Gene sequence:

>879_bases
TTGCCTGAATTACCTGAAGTAGAAACAGTTCGAAGAGGTTTAGAGCAAAAACTTAATAACTTTATTATTAAAAAAGTAGA
AATCTGTAGGTATTCAACTGTTGCATTCCCAACAAACAAAGAAGAATTCATTAAAGGACTTCGGAACTCACTTATTTATA
AATGGGATAGAAGAGGAAAATATTTAATAGCCCAATTAAAAGAAGTTCAAAATGAGCATACTCAACTTCCTCTAGAAAAT
TCACAAAATAACGGATTTCTTGTAGTTCATCTAAGAATGACTGGATATTTTAAATTTATTGAAAACTCAAGTAATCCCTG
TAAACATACAAGAGTAAGATTTTTCGATAAAAATAATAATGAGCTTAGGTACATCGACGTAAGAAGTTTTGGTCAAATGT
GGTGGATTAATAATGACCTATCGCTTAACAAAATAATTAAAGGATTAGGTTCATTAGGACCAGAGCCATTTTCTAAAGAC
TTTAATGCAAATTACCTTAAGAAAGTTATTTCAAAAAGAACAAAATCTATTAAAGCCATTTTATTAGATCAAACAATAGT
GGCGGGAATAGGTAATATTTATGCTGATGAAAGTTTATACTCTGCTGGCATTTCCCCTTTTAGGGAAGCTCGAACAATAA
AAAAAAATGAGTTAATCAAACTCAAAGAATCAATTGTAACTGTATTAAAAAAAAGTATAGGTTCTGGGGGTACCACATTT
AGCGATTTTAGAGACCTGGAAGGAGAGAATGGGAATTTTGGTTTGCAGACAAATGTCTATAGGAGAACTGGAAAAGAATG
TCGTAAATGTGGAAATTTAATTGAAAGACAAAAAATTACTGGAAGAAGTACCCATTGGTGTCCTAAATGCCAAAAATAA

Upstream 100 bases:

>100_bases
GTCAGATTCGATAAAGTAAATTACGCTGGGATTAGCGGAACTGATGGTGGAGCAAATACAAATAATTTCGCTGAAAGTGA
ATTAGAAAAAGCTTAAATAA

Downstream 100 bases:

>100_bases
AAAAGGGCTTACTCAAGAAGAGTAAGCCCTTTTAAATATTTTTACCTGGCATTGAGCTATTTTCTCAAGGGGCTACCCCC
TAAATATTTTCGCCGCTGAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MPELPEVETVRRGLEQKLNNFIIKKVEICRYSTVAFPTNKEEFIKGLRNSLIYKWDRRGKYLIAQLKEVQNEHTQLPLEN
SQNNGFLVVHLRMTGYFKFIENSSNPCKHTRVRFFDKNNNELRYIDVRSFGQMWWINNDLSLNKIIKGLGSLGPEPFSKD
FNANYLKKVISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKESIVTVLKKSIGSGGTTF
SDFRDLEGENGNFGLQTNVYRRTGKECRKCGNLIERQKITGRSTHWCPKCQK

Sequences:

>Translated_292_residues
MPELPEVETVRRGLEQKLNNFIIKKVEICRYSTVAFPTNKEEFIKGLRNSLIYKWDRRGKYLIAQLKEVQNEHTQLPLEN
SQNNGFLVVHLRMTGYFKFIENSSNPCKHTRVRFFDKNNNELRYIDVRSFGQMWWINNDLSLNKIIKGLGSLGPEPFSKD
FNANYLKKVISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKESIVTVLKKSIGSGGTTF
SDFRDLEGENGNFGLQTNVYRRTGKECRKCGNLIERQKITGRSTHWCPKCQK
>Mature_291_residues
PELPEVETVRRGLEQKLNNFIIKKVEICRYSTVAFPTNKEEFIKGLRNSLIYKWDRRGKYLIAQLKEVQNEHTQLPLENS
QNNGFLVVHLRMTGYFKFIENSSNPCKHTRVRFFDKNNNELRYIDVRSFGQMWWINNDLSLNKIIKGLGSLGPEPFSKDF
NANYLKKVISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKESIVTVLKKSIGSGGTTFS
DFRDLEGENGNFGLQTNVYRRTGKECRKCGNLIERQKITGRSTHWCPKCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=292, Percent_Identity=38.013698630137, Blast_Score=187, Evalue=5e-49,
Organism=Escherichia coli, GI1786932, Length=300, Percent_Identity=22, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 33695; Mature: 33564

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLEQKLNNFIIKKVEICRYSTVAFPTNKEEFIKGLRNSLIYKWDRRGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHEEEECCCCH
YLIAQLKEVQNEHTQLPLENSQNNGFLVVHLRMTGYFKFIENSSNPCKHTRVRFFDKNNN
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCEEHHHCCCCCCCCCCEEEEEECCCC
ELRYIDVRSFGQMWWINNDLSLNKIIKGLGSLGPEPFSKDFNANYLKKVISKRTKSIKAI
EEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKESIVTVLKKSIGSGGTTF
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SDFRDLEGENGNFGLQTNVYRRTGKECRKCGNLIERQKITGRSTHWCPKCQK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLEQKLNNFIIKKVEICRYSTVAFPTNKEEFIKGLRNSLIYKWDRRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHEEEECCCCH
YLIAQLKEVQNEHTQLPLENSQNNGFLVVHLRMTGYFKFIENSSNPCKHTRVRFFDKNNN
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCEEHHHCCCCCCCCCCEEEEEECCCC
ELRYIDVRSFGQMWWINNDLSLNKIIKGLGSLGPEPFSKDFNANYLKKVISKRTKSIKAI
EEEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKESIVTVLKKSIGSGGTTF
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SDFRDLEGENGNFGLQTNVYRRTGKECRKCGNLIERQKITGRSTHWCPKCQK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA