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The map label for this gene is cobD [H]

Identifier: 123967753

GI number: 123967753

Start: 201774

End: 202895

Strand: Reverse

Name: cobD [H]

Synonym: A9601_02161

Alternate gene names: 123967753

Gene position: 202895-201774 (Counterclockwise)

Preceding gene: 123967754

Following gene: 123967751

Centisome position: 12.15

GC content: 31.28

Gene sequence:

>1122_bases
ATGAATAATGAACCTCATGATTACTCAACGTTAGCCATGCAAGGATCAAACTTGAAGCACGGTGGAAATGTATATGCAAT
TGCGAAAAAATTAAATTTATTACCCTCCGAAATCATTGATGCTAGTGCATCATTAGTACCCTTTGATCCACCTCAAATAC
TCATAGATTCAATAAATGCCGAAATTAAGAATCTTGGCTTTAGATATTACCCAGAAAGAAACTTAAGTGATCTGAAAGAA
ATAATCGGCAAATTTCATGAGATAAATCCAGATAATGTATTGCCTGGGAATGGAGCTTCTGAATTAATAACCTGGGCAGG
TTATGAAGCATCCAAATTCGGAATCAGTTGTATTCCTTCTCCATCATTTGTTGATTATGAAAGATCTTTAAATTGTTGGA
ATAGCAATTTTATAAATTGCGAATTACCAAAAAACTGGAGTGATATTTTTCCTCAATCATTTCCGCTTCATCCAAAAGGT
GATGTTCTTTGGATAACAAATCCACATAACCCTACCGGCCAATTATGGGAAAAGAATTCATTGGAGGAAGTTGTAAAAAA
ATATAAATTAGTTATCTGCGATGAAGCTTTTTTATCCATAACACCTAATGGAGACAAAGAATCTTTAATACCATTAACCA
AAAGATTTGATAATTTATTAGTCTTGAGAAGCTTGACCAAAATCTTCAATATTCCTGGACTTAGATTAGGTTACGTTATT
GGCTCATCGAAAAAACTTAAACAATGGGAAATAAATAGAGATCCTTGGCCTTTAAATTCATTTTCTATTAAAGCCGGGAT
TGATCTACTAAGTAATAAGAAATTCTATGAACAGTGGACAAAACAGATTCACAGCTGGATAAATATTGAAAAAAAGAGAG
TATTTGAAAAATTATTAAAAATAGAGAACCTTAAAATTCATAACTCTTCAACCAACTTTTTTTTAATAGAAAGTGAAACA
TCCTTGTCGCCAAATATAAAATACTTAGAAAATAAGGGAATATTGCTTAGAGAATGCACTTCATTTAGATTTCTTGACGA
AAAGTGGGCAAGAATAAGTCTACAGAATAGAAAAAATAACACTCTTTTATGTGAAGAAATTCAGAATTCCTTTAAAAAAT
AA

Upstream 100 bases:

>100_bases
TATACTTGAGGGAATTATAAAGCAACTCAATAACCATCAATTATCTAGTATAAAAGATGCAATTGGATCAGATTTAAAAT
GGATTGAATAAAATTAGAGA

Downstream 100 bases:

>100_bases
TCAATATACTTTTTAATCTCATTTTTAGATTTAATTTTATTATTGTTTTCCATATTCTTCTTCATGAGATCTAATATTTC
ATAATTTTTTTTTCCCTTTT

Product: aminotransferases class-I

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MNNEPHDYSTLAMQGSNLKHGGNVYAIAKKLNLLPSEIIDASASLVPFDPPQILIDSINAEIKNLGFRYYPERNLSDLKE
IIGKFHEINPDNVLPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFINCELPKNWSDIFPQSFPLHPKG
DVLWITNPHNPTGQLWEKNSLEEVVKKYKLVICDEAFLSITPNGDKESLIPLTKRFDNLLVLRSLTKIFNIPGLRLGYVI
GSSKKLKQWEINRDPWPLNSFSIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLLKIENLKIHNSSTNFFLIESET
SLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNRKNNTLLCEEIQNSFKK

Sequences:

>Translated_373_residues
MNNEPHDYSTLAMQGSNLKHGGNVYAIAKKLNLLPSEIIDASASLVPFDPPQILIDSINAEIKNLGFRYYPERNLSDLKE
IIGKFHEINPDNVLPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFINCELPKNWSDIFPQSFPLHPKG
DVLWITNPHNPTGQLWEKNSLEEVVKKYKLVICDEAFLSITPNGDKESLIPLTKRFDNLLVLRSLTKIFNIPGLRLGYVI
GSSKKLKQWEINRDPWPLNSFSIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLLKIENLKIHNSSTNFFLIESET
SLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNRKNNTLLCEEIQNSFKK
>Mature_373_residues
MNNEPHDYSTLAMQGSNLKHGGNVYAIAKKLNLLPSEIIDASASLVPFDPPQILIDSINAEIKNLGFRYYPERNLSDLKE
IIGKFHEINPDNVLPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFINCELPKNWSDIFPQSFPLHPKG
DVLWITNPHNPTGQLWEKNSLEEVVKKYKLVICDEAFLSITPNGDKESLIPLTKRFDNLLVLRSLTKIFNIPGLRLGYVI
GSSKKLKQWEINRDPWPLNSFSIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLLKIENLKIHNSSTNFFLIESET
SLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNRKNNTLLCEEIQNSFKK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=277, Percent_Identity=25.9927797833935, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42905; Mature: 42905

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNEPHDYSTLAMQGSNLKHGGNVYAIAKKLNLLPSEIIDASASLVPFDPPQILIDSINA
CCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHH
EIKNLGFRYYPERNLSDLKEIIGKFHEINPDNVLPGNGASELITWAGYEASKFGISCIPS
HHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCCCCCEECCC
PSFVDYERSLNCWNSNFINCELPKNWSDIFPQSFPLHPKGDVLWITNPHNPTGQLWEKNS
CCCCCHHHCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
LEEVVKKYKLVICDEAFLSITPNGDKESLIPLTKRFDNLLVLRSLTKIFNIPGLRLGYVI
HHHHHHHHEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GSSKKLKQWEINRDPWPLNSFSIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLLK
CCCCCCEEEECCCCCCCCCCEEHHHCCHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
IENLKIHNSSTNFFLIESETSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNRKNN
HCCEEEECCCCCEEEEECCCCCCCCCEEECCCCEEEEHHCCHHHHHHHHHEEEEECCCCC
TLLCEEIQNSFKK
CEEHHHHHHHHCC
>Mature Secondary Structure
MNNEPHDYSTLAMQGSNLKHGGNVYAIAKKLNLLPSEIIDASASLVPFDPPQILIDSINA
CCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHH
EIKNLGFRYYPERNLSDLKEIIGKFHEINPDNVLPGNGASELITWAGYEASKFGISCIPS
HHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCCCCCEECCC
PSFVDYERSLNCWNSNFINCELPKNWSDIFPQSFPLHPKGDVLWITNPHNPTGQLWEKNS
CCCCCHHHCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
LEEVVKKYKLVICDEAFLSITPNGDKESLIPLTKRFDNLLVLRSLTKIFNIPGLRLGYVI
HHHHHHHHEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GSSKKLKQWEINRDPWPLNSFSIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLLK
CCCCCCEEEECCCCCCCCCCEEHHHCCHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
IENLKIHNSSTNFFLIESETSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNRKNN
HCCEEEECCCCCEEEEECCCCCCCCCEEECCCCEEEEHHCCHHHHHHHHHEEEEECCCCC
TLLCEEIQNSFKK
CEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]