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The map label for this gene is nadC [H]

Identifier: 123967743

GI number: 123967743

Start: 189877

End: 190743

Strand: Reverse

Name: nadC [H]

Synonym: A9601_02061

Alternate gene names: 123967743

Gene position: 190743-189877 (Counterclockwise)

Preceding gene: 123967744

Following gene: 123967742

Centisome position: 11.42

GC content: 29.18

Gene sequence:

>867_bases
GTGGATTTAAATACTCCAATAATAAGTAAAATCATTGATAATTGGATCGATGAAGATATAGGTAGGGGAGATCTTACAAG
TTCCTCTATTACAGAAGAGAATGGTAATGCATATTGGATTGCAAAAGAAGAGGGTATATTCTGCGGGGTTGAAATTATAA
AAGAAATTTTTAGAAAAATTGATTTAAAAATCAGTCCAAAATTTAATATCTCTGATGGAGATCAATTTGTTAAAGATCAA
AAACTCTTAGAAATATATGGGCCTTCAAAAAGTTTGCTAGCTAGTGAAAGAATAAGCTTAAATATAGCAATGCATTTATC
TGGAATATCAACATACACAAAGAATCTTGTAAATAAGTTAGAAGGTACAAATATAAAATTAGCAGATACTAGGAAAACGA
CTCCTGGCTTAAGAATATTTGAAAAATATGCATTCAAATGCGGAGGTGGAGTCAATCATAGAATGGGATTATACGATGCA
GCTATGATAAAAGAAAATCACATTGCATGGACAGATAATCTTAATAATGCAGTAAAAAAAATTCGAATAAATTCGCCTTT
TACAACTCATATCATAATTGAAGCTGAGAATATCGAACAGGCAAAAGAAGCAGTATTAGCAGGAGCAGATAGTGTCTTAT
TGGATGAACTTAGCCCTGAAATAATCAAAAAAAACGTTCAAGAATTAAGAGATTTATCAATGAATAGCTTAAAAAAAGAA
GTAAATAAAAATTTGATAATAGAAGTTTCTGGAATTAACCCTGAAGAAATTAGTAAATATCTAATAAAAGGTATTGATTT
GATTTCAACAAGTTCTTCAATCACCAAAAGTAATTGGATTGATTTGAGTATGCGTTATATTAATTAA

Upstream 100 bases:

>100_bases
TTTTGTATTGGTAAATAAATTTGAGTTAAATTACATAGTGATATATAGTTGATTCTCTAACTTCAGTTTAATTTTTATTA
ATTAATTATTTATTAGTTTA

Downstream 100 bases:

>100_bases
CTATATAGATAAATAATTGAATAATTAATGCTAATCATTTTTAAAGAATTAACAAAACAATTTGAACAATCTCTTTTAGA
TAGTCTTGAAAATAATGATA

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSSSITEENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDQFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRINSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIKKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPEEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Sequences:

>Translated_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSSSITEENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDQFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRINSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIKKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPEEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
>Mature_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSSSITEENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDQFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRINSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIKKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPEEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=28.6219081272085, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1786299, Length=289, Percent_Identity=36.3321799307958, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=284, Percent_Identity=33.0985915492958, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32289; Mature: 32289

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTSSSITEENGNAYWIAKEEGIFCGVEIIKEIFRKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEECHHHHHHHHHHC
DLKISPKFNISDGDQFVKDQKLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLVNKL
CCEECCCCCCCCCHHHHHHHHEEEEECCCHHHHHHHCEEEEEEEEECCHHHHHHHHHHHH
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRINSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIKKNVQELRDLSMNSLKKE
EECCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPEEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTSSSITEENGNAYWIAKEEGIFCGVEIIKEIFRKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEECHHHHHHHHHHC
DLKISPKFNISDGDQFVKDQKLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLVNKL
CCEECCCCCCCCCHHHHHHHHEEEEECCCHHHHHHHCEEEEEEEEECCHHHHHHHHHHHH
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRINSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIKKNVQELRDLSMNSLKKE
EECCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPEEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]