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The map label for this gene is cysK [H]

Identifier: 123967678

GI number: 123967678

Start: 131832

End: 132800

Strand: Reverse

Name: cysK [H]

Synonym: A9601_01411

Alternate gene names: 123967678

Gene position: 132800-131832 (Counterclockwise)

Preceding gene: 123967681

Following gene: 123967677

Centisome position: 7.95

GC content: 34.67

Gene sequence:

>969_bases
ATGGAAATAGCAAATGATATAACTTCTCTAGTGGGAAATACTCCATTAGTAAAATTAAATCGAATCAGAAAGTATTTTGA
TTGTTATCCAGAAATAATAGCCAAACTAGAAAGTTTCAATCCATCAGCTTCCGTCAAGGATAGGATCGCTTATTCAATGT
TGTGTAAAGCTGAAGAAGAAGGATTGATAACACCAGATAAAACAACGTTAATTGAAGCAACTAGTGGGAATACTGGCATC
GCATTAGCAATGGTTGCTGCAGCAAAAGGCTATAAATTGATATTAACTATGCCTGATACTATGAGTATTGAGAGAAGGGC
AATGTTGAGAGCATATGGAGCTGAATTACAGCTAACTCCAGGAAAAGACGGAATGAAAGGAGCTTTAGATTTAGCTAATG
AGTTGTCTTCAACTATTGCAAATAGCTATCAATTTAATCAGTTTGAAAACTTTGCTAATCCAGATATTCATGAAAGAACA
ACAGCCCAAGAAATATGGTCTCAATCCAATAACAATTTAGATGGACTAGTTACAGGGGTCGGCACAGGAGGAACAATTAC
TGGTTGTGCACGTTTTTTGAAAAAAGTTAATCCAAATTGCAAAATTTATGCCGTAGAGCCAAAAAAAAGTGCTGTGATTT
CTGGAGAAAAAGCAGGCTCACATTCGATTCAAGGAATTGGAGCGGGTTTCGTACCAAAAGTACTTAATACGAAATTAATT
GATGAAATTATAAAAATAGATGACGATGAAGCATTTTATTTTGGGCGTTTATTAGCTCGATTGGAAGGTCTTTTATCTGG
TATCAGCAGTGGAGCAGCTTTAGCAGCAACTATAAAAATCGGCAAAAGAAAAGAACTAATGAAAAAAAGATTGATAGTTA
TTCTTCCAAGTTTTGGAGAAAGATATTTATCAACAGCAATGTTTGAATCTAATACCTCAATTCAAGCCAGAAAAGATGGT
TATCTTTAA

Upstream 100 bases:

>100_bases
ATTAAAATTAAATTATTTTGAGAAAATTATATAAAAGAACATTAAATACAATTATTATTATGATAGGAGATTTTATTTTG
CATTTTAAAAAATAATTTTC

Downstream 100 bases:

>100_bases
TGCAAAATTTATAAAAATGGAAAAAAATTTATATGAAGAATTAGGTCTCAAAAACAATGCAACCAGAAGTGAAATTAAAT
CTTCATATCGCTCTTTAGTT

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEIANDITSLVGNTPLVKLNRIRKYFDCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKDGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPKKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYFGRLLARLEGLLSGISSGAALAATIKIGKRKELMKKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL

Sequences:

>Translated_322_residues
MEIANDITSLVGNTPLVKLNRIRKYFDCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKDGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPKKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYFGRLLARLEGLLSGISSGAALAATIKIGKRKELMKKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL
>Mature_322_residues
MEIANDITSLVGNTPLVKLNRIRKYFDCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGKDGMKGALDLANELSSTIANSYQFNQFENFANPDIHERT
TAQEIWSQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPKKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYFGRLLARLEGLLSGISSGAALAATIKIGKRKELMKKRLIVILPSFGERYLSTAMFESNTSIQARKDG
YL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=42.3076923076923, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=42.3076923076923, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=42.3076923076923, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=50.9493670886076, Blast_Score=264, Evalue=5e-72,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=43.2885906040268, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=50.1672240802676, Blast_Score=296, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=50.814332247557, Blast_Score=294, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=47.3856209150327, Blast_Score=281, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=48.1727574750831, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=44.8051948051948, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=45.2830188679245, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=327, Percent_Identity=35.474006116208, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=35.3503184713376, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=36.6666666666667, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=40.3174603174603, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=33.0275229357798, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=39.8148148148148, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=39.8148148148148, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34975; Mature: 34975

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIANDITSLVGNTPLVKLNRIRKYFDCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEE
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GLITPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GKDGMKGALDLANELSSTIANSYQFNQFENFANPDIHERTTAQEIWSQSNNNLDGLVTGV
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPKKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDEAFYFGRLLARLEGLLSGISSGAALAATIKIGKRKELMKKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCEEEEECCCCH
RYLSTAMFESNTSIQARKDGYL
HHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure
MEIANDITSLVGNTPLVKLNRIRKYFDCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEE
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GLITPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GKDGMKGALDLANELSSTIANSYQFNQFENFANPDIHERTTAQEIWSQSNNNLDGLVTGV
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPKKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDEAFYFGRLLARLEGLLSGISSGAALAATIKIGKRKELMKKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCEEEEECCCCH
RYLSTAMFESNTSIQARKDGYL
HHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]