Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 123967619

GI number: 123967619

Start: 85602

End: 86855

Strand: Reverse

Name: csd [H]

Synonym: A9601_00821

Alternate gene names: 123967619

Gene position: 86855-85602 (Counterclockwise)

Preceding gene: 123967620

Following gene: 123967617

Centisome position: 5.2

GC content: 31.82

Gene sequence:

>1254_bases
ATGGAAACGATTCAAAATTTTCCTGAAATAACTAAGAAAGACTTTCCTCTTTTAAATAACAACATAAAAAATAATGAGCA
AATCATTTATTTAGACCATGCTGCAACCACGCAAAAACCAATTCAAGTCTTGAAAAAAATTGATGAATATTATAGAAATT
TTAATGCCAATGTACATAGAGGAGCTCATCAATTAAGTGCTAAAGCGACAGAAGAATTTGAAAATGCAAGATTTTCAATT
AGTAAATACATCAAAGCAAATTCGCCAAAAGAAATTATTTTCACAAGAAATGCTACTGAAGCAATAAATCTAGCAGCTAG
ATCATGGGGCGAATATTCATTAGGAGAAAACGATGAAATTCTTCTATCAATAATGGAGCATCATAGCAATATTGTTCCAT
GGCAAATGGTTGCAGCGAAAAATAAGTGTAAATTAAAATTTATAGGCATCGATAAAAATGGGCAATTAGATTTAGACGAT
TTTAAGTCAAAACTAACCTCTAGAACAAAGCTTGTTAGCCTAGTACATGTAAGTAATACTCTAGGTTGCTGTAATCCAAT
CAAAGAGATAACTAAATTAGCTAAACAAAAAGGTTCTCTAGTATTAATAGATGCATGTCAAAGTTTGGCGCATCAAAAAC
TAGATGTAATAGATCTTGATATTGATTTTTTAGCGGGATCAGGACATAAACTTTGCGGTCCTACAGGAATTGGTTTCCTC
TGGTCAAGACAAGAAATTCTTGAAAAAATTCCTCCTTTCTTTGGAGGTGGCGAAATGATTCAAGATGTCTTTGAAGAGAC
AAGTACCTGGGCTGATCTCCCACATAAATTCGAAGCTGGAACTCCAGCCATTGCAGAAGCAATAGGCCTTGCGGAAGCAA
TTAATTATATAAACACTATAGGATTAAATGAAATTAATGAATATGAAAAGACTATTACTAAATATTTATTTGAAAAATTA
AATCAAATAGAAAATATTGAAATTATAGGTCCACCGCCGGAGATAGATCCAGACAGAGCCTCACTTGCCACCTTTTATAT
AAAAAATATACATTCAAATGATATTGCTGAAATTCTTGATTCAAAAGGAATTTGCATCAGAAGTGGTCACCATTGCTGTC
AACCTCTTCACAGATACATCGGAATTAAATCAACAGCTAGAATCAGTATGAATTTCACAACCAATAAGGAGGAAATTGAT
ATATTTCTTGAAAAATTAAAAGATACTATTGATTTTCTAAAAATCAATTCTTAA

Upstream 100 bases:

>100_bases
GTAAACTACAATTAAGTTCATACTTTCAAGAAATAATTTCATTTATTCCCGTTTCAAAAGATAGATGGGATTTGCTTGAT
AAACTTTTAAATGAAAAATA

Downstream 100 bases:

>100_bases
ATATTCAAAGCATTTTTTAAAAATTCCATAGATTTTTGCATTACTATTTCTTTATTTTCAATATTTCTAAAACCGTGCCC
CTCATTATCAAAAAAAATAA

Product: putative cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
METIQNFPEITKKDFPLLNNNIKNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARFSI
SKYIKANSPKEIIFTRNATEAINLAARSWGEYSLGENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGQLDLDD
FKSKLTSRTKLVSLVHVSNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPFFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLNEINEYEKTITKYLFEKL
NQIENIEIIGPPPEIDPDRASLATFYIKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKDTIDFLKINS

Sequences:

>Translated_417_residues
METIQNFPEITKKDFPLLNNNIKNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARFSI
SKYIKANSPKEIIFTRNATEAINLAARSWGEYSLGENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGQLDLDD
FKSKLTSRTKLVSLVHVSNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPFFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLNEINEYEKTITKYLFEKL
NQIENIEIIGPPPEIDPDRASLATFYIKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKDTIDFLKINS
>Mature_417_residues
METIQNFPEITKKDFPLLNNNIKNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHRGAHQLSAKATEEFENARFSI
SKYIKANSPKEIIFTRNATEAINLAARSWGEYSLGENDEILLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGQLDLDD
FKSKLTSRTKLVSLVHVSNTLGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
WSRQEILEKIPPFFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTIGLNEINEYEKTITKYLFEKL
NQIENIEIIGPPPEIDPDRASLATFYIKNIHSNDIAEILDSKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEID
IFLEKLKDTIDFLKINS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=402, Percent_Identity=25.1243781094527, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156713448, Length=263, Percent_Identity=29.277566539924, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1787970, Length=398, Percent_Identity=41.2060301507538, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=31.7733990147783, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=25.4364089775561, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25143064, Length=297, Percent_Identity=29.2929292929293, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193211090, Length=400, Percent_Identity=25.75, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=26.3959390862944, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20129463, Length=284, Percent_Identity=30.6338028169014, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47032; Mature: 47032

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIQNFPEITKKDFPLLNNNIKNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENARFSISKYIKANSPKEIIFTRNATEAINLAARSWGEYSLGENDEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHH
LLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGQLDLDDFKSKLTSRTKLVSLVHVSNT
HHHHHHHCCCCCCHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
HHCHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCHH
WSRQEILEKIPPFFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTI
HCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLNEINEYEKTITKYLFEKLNQIENIEIIGPPPEIDPDRASLATFYIKNIHSNDIAEILD
CCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDIFLEKLKDTIDFLKINS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
METIQNFPEITKKDFPLLNNNIKNNEQIIYLDHAATTQKPIQVLKKIDEYYRNFNANVHR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHH
GAHQLSAKATEEFENARFSISKYIKANSPKEIIFTRNATEAINLAARSWGEYSLGENDEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHH
LLSIMEHHSNIVPWQMVAAKNKCKLKFIGIDKNGQLDLDDFKSKLTSRTKLVSLVHVSNT
HHHHHHHCCCCCCHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LGCCNPIKEITKLAKQKGSLVLIDACQSLAHQKLDVIDLDIDFLAGSGHKLCGPTGIGFL
HHCHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCHH
WSRQEILEKIPPFFGGGEMIQDVFEETSTWADLPHKFEAGTPAIAEAIGLAEAINYINTI
HCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GLNEINEYEKTITKYLFEKLNQIENIEIIGPPPEIDPDRASLATFYIKNIHSNDIAEILD
CCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHC
SKGICIRSGHHCCQPLHRYIGIKSTARISMNFTTNKEEIDIFLEKLKDTIDFLKINS
CCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]