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The map label for this gene is accC [H]

Identifier: 123967609

GI number: 123967609

Start: 77058

End: 78407

Strand: Direct

Name: accC [H]

Synonym: A9601_00721

Alternate gene names: 123967609

Gene position: 77058-78407 (Clockwise)

Preceding gene: 123967607

Following gene: 123967611

Centisome position: 4.61

GC content: 37.26

Gene sequence:

>1350_bases
ATGGTTGAAAAAGTTTTAATTGCTAATCGTGGAGAAATAGCTTTACGAATTGTCAGAAGTTGTAGAGAACTAGGGATTGC
AACAGTTGCAGTTTTTAGCACTGTTGATAAAAAAGCATTGCATGTTCAGCTTGCTGATGAGGCGGTTTGCGTCGGAGATT
CATTAAGTAATAAGAGTTATTTAAATATTCCAAATATACTTGCTGCTGCTACATCAAGAGGAGTTGATGCTATTCATCCT
GGTTATGGATTTCTTGCGGAAAATGATAAATTTGCTGAGATGTGTAACGATCATGGCATAGTTTTTATTGGCCCATCTCC
TAAAGCTATTAGATCTATGGGAGATAAATCTACAGCTAAAGAAACTATGGAAGCAGTTGGAGTTCCAACAGTACCTGGCA
GTAAAGGCTTGTTATCAAATGTTGATGAGGCTTATAAATTGGCAGATGATATTGGCTATCCGGTAATTATTAAAGCGACT
GCTGGAGGAGGCGGAAGAGGTATGAGGTTGGTTGAAAACTCCAATAATCTAGAAAAAATGTTTAAAGCAGCTCAAGGCGA
AGCAGAAGCAGCTTTTGGTAATGATGGTTTATATATGGAGAAATTTATAAAGAAGCCAAGACATGTAGAAATTCAAATTT
TGGCTGACAGGTCGGGTAATGTTGTTCACTTAGGAGAGCGAGATTGTTCAGTTCAAAGAAGACATCAGAAGTTACTAGAA
GAGTCTCCCAGTCCTGCAATTAACCCTGCGCTAAGAAAAAAAATGGGGAACGCAGCTATTGCTGCTGCAAAAAGTATCGG
CTACGAAGGAGCGGGGACAGTTGAATTTTTAGTTGATGATGATGATAATTTTTATTTTATGGAAATGAATACTAGGATTC
AAGTTGAACATCCTGTTACTGAAATGGTTACAGGAGTAGATTTAATAGCTGAGCAAATTAAAATCGCAAGCGGAGCAAAC
TTGGAATTTAGTCAGGATGATATCCATTTAAACGGTCATGCCATTGAATGTAGAATCAATGCTGAAGATCCTTCTCACAA
TTTCCGACCATCACCTGGAAAAATAACTGGGTGGCTTCCTCCTGGTGGCCCTGGTGTAAGGGTGGATAGTCATGTTTATA
CAGGCTATGAAATACCTCCTTTCTATGACTCATTAATTGGTAAATTAATAGTCTGGGGAAAAGATCGTAATACTGCAATT
AAACGTATGAATAGGGCTTTAAATGAATGTGCGGTCACTGGTATTCCTACAACAATTAACTTTCATCTAACTTTACTAAA
TAAATCTAAATTTAAGCAGGGTAAGATACATACTAAATATGTAGAAGAAGAATTATTGCCAAATTACTGA

Upstream 100 bases:

>100_bases
TTGTAAAAAATGTCCTCTGATTACTAAAAAAATTTGTTGAATACTTTGGCAAATAATTTTTTATTTTAAGTCATTTCATT
TCTTCAATTTTATTTTCATA

Downstream 100 bases:

>100_bases
GAAATAATTAATTATTTCTATGAAATATGTGTATGTAATGCAAGTTTTACAAGCCCTTGCTGACCGACTAAAATTTCTCT
TAAAAAGCTTATAACTCCGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MVEKVLIANRGEIALRIVRSCRELGIATVAVFSTVDKKALHVQLADEAVCVGDSLSNKSYLNIPNILAAATSRGVDAIHP
GYGFLAENDKFAEMCNDHGIVFIGPSPKAIRSMGDKSTAKETMEAVGVPTVPGSKGLLSNVDEAYKLADDIGYPVIIKAT
AGGGGRGMRLVENSNNLEKMFKAAQGEAEAAFGNDGLYMEKFIKKPRHVEIQILADRSGNVVHLGERDCSVQRRHQKLLE
ESPSPAINPALRKKMGNAAIAAAKSIGYEGAGTVEFLVDDDDNFYFMEMNTRIQVEHPVTEMVTGVDLIAEQIKIASGAN
LEFSQDDIHLNGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYEIPPFYDSLIGKLIVWGKDRNTAI
KRMNRALNECAVTGIPTTINFHLTLLNKSKFKQGKIHTKYVEEELLPNY

Sequences:

>Translated_449_residues
MVEKVLIANRGEIALRIVRSCRELGIATVAVFSTVDKKALHVQLADEAVCVGDSLSNKSYLNIPNILAAATSRGVDAIHP
GYGFLAENDKFAEMCNDHGIVFIGPSPKAIRSMGDKSTAKETMEAVGVPTVPGSKGLLSNVDEAYKLADDIGYPVIIKAT
AGGGGRGMRLVENSNNLEKMFKAAQGEAEAAFGNDGLYMEKFIKKPRHVEIQILADRSGNVVHLGERDCSVQRRHQKLLE
ESPSPAINPALRKKMGNAAIAAAKSIGYEGAGTVEFLVDDDDNFYFMEMNTRIQVEHPVTEMVTGVDLIAEQIKIASGAN
LEFSQDDIHLNGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYEIPPFYDSLIGKLIVWGKDRNTAI
KRMNRALNECAVTGIPTTINFHLTLLNKSKFKQGKIHTKYVEEELLPNY
>Mature_449_residues
MVEKVLIANRGEIALRIVRSCRELGIATVAVFSTVDKKALHVQLADEAVCVGDSLSNKSYLNIPNILAAATSRGVDAIHP
GYGFLAENDKFAEMCNDHGIVFIGPSPKAIRSMGDKSTAKETMEAVGVPTVPGSKGLLSNVDEAYKLADDIGYPVIIKAT
AGGGGRGMRLVENSNNLEKMFKAAQGEAEAAFGNDGLYMEKFIKKPRHVEIQILADRSGNVVHLGERDCSVQRRHQKLLE
ESPSPAINPALRKKMGNAAIAAAKSIGYEGAGTVEFLVDDDDNFYFMEMNTRIQVEHPVTEMVTGVDLIAEQIKIASGAN
LEFSQDDIHLNGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYEIPPFYDSLIGKLIVWGKDRNTAI
KRMNRALNECAVTGIPTTINFHLTLLNKSKFKQGKIHTKYVEEELLPNY

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=48.7528344671202, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=47.8555304740406, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=47.8555304740406, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=47.8555304740406, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=47.8747203579418, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=47.8747203579418, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=47.8747203579418, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=34.1846758349705, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=34.1846758349705, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=34.1846758349705, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=34.1846758349705, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=34.1846758349705, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=33.1372549019608, Blast_Score=268, Evalue=7e-72,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=55.8295964125561, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.1783295711061, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=47.1655328798186, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=45.6179775280899, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=31.9018404907975, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=29.9212598425197, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=29.9212598425197, Blast_Score=236, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=43.2432432432432, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.9664429530201, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=44.7427293064877, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=34.051724137931, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=32.2393822393822, Blast_Score=249, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=47.2035794183445, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.8747203579418, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=46.2102689486553, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=32.1428571428571, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=32.1428571428571, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=32.1428571428571, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=32.1428571428571, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48940; Mature: 48940

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKVLIANRGEIALRIVRSCRELGIATVAVFSTVDKKALHVQLADEAVCVGDSLSNKSY
CCCEEEEECCCHHHHHHHHHHHHCCHHHEEHHHHCCCCEEEEEECCCEEEECCCCCCCCE
LNIPNILAAATSRGVDAIHPGYGFLAENDKFAEMCNDHGIVFIGPSPKAIRSMGDKSTAK
ECCCHHHHHHHHCCCCEECCCCCEEECCCHHHHHHCCCCEEEECCCCHHHHHCCCHHHHH
ETMEAVGVPTVPGSKGLLSNVDEAYKLADDIGYPVIIKATAGGGGRGMRLVENSNNLEKM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH
FKAAQGEAEAAFGNDGLYMEKFIKKPRHVEIQILADRSGNVVHLGERDCSVQRRHQKLLE
HHHHCCCCCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPAINPALRKKMGNAAIAAAKSIGYEGAGTVEFLVDDDDNFYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCHH
EMVTGVDLIAEQIKIASGANLEFSQDDIHLNGHAIECRINAEDPSHNFRPSPGKITGWLP
HHHHHHHHHHHHHHHCCCCCCEECCCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEECC
PGGPGVRVDSHVYTGYEIPPFYDSLIGKLIVWGKDRNTAIKRMNRALNECAVTGIPTTIN
CCCCCCEECCEEEECCCCCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHEECCCCEEEE
FHLTLLNKSKFKQGKIHTKYVEEELLPNY
EEEEEEECCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVEKVLIANRGEIALRIVRSCRELGIATVAVFSTVDKKALHVQLADEAVCVGDSLSNKSY
CCCEEEEECCCHHHHHHHHHHHHCCHHHEEHHHHCCCCEEEEEECCCEEEECCCCCCCCE
LNIPNILAAATSRGVDAIHPGYGFLAENDKFAEMCNDHGIVFIGPSPKAIRSMGDKSTAK
ECCCHHHHHHHHCCCCEECCCCCEEECCCHHHHHHCCCCEEEECCCCHHHHHCCCHHHHH
ETMEAVGVPTVPGSKGLLSNVDEAYKLADDIGYPVIIKATAGGGGRGMRLVENSNNLEKM
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH
FKAAQGEAEAAFGNDGLYMEKFIKKPRHVEIQILADRSGNVVHLGERDCSVQRRHQKLLE
HHHHCCCCCEEECCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPAINPALRKKMGNAAIAAAKSIGYEGAGTVEFLVDDDDNFYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCHH
EMVTGVDLIAEQIKIASGANLEFSQDDIHLNGHAIECRINAEDPSHNFRPSPGKITGWLP
HHHHHHHHHHHHHHHCCCCCCEECCCCEEECCEEEEEEEECCCCCCCCCCCCCCEEEECC
PGGPGVRVDSHVYTGYEIPPFYDSLIGKLIVWGKDRNTAIKRMNRALNECAVTGIPTTIN
CCCCCCEECCEEEECCCCCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHEECCCCEEEE
FHLTLLNKSKFKQGKIHTKYVEEELLPNY
EEEEEEECCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]