Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 123967558

GI number: 123967558

Start: 22479

End: 23828

Strand: Reverse

Name: murC [H]

Synonym: A9601_00211

Alternate gene names: 123967558

Gene position: 23828-22479 (Counterclockwise)

Preceding gene: 123967560

Following gene: 123967557

Centisome position: 1.43

GC content: 28.81

Gene sequence:

>1350_bases
ATGTCAGCATTAGCAATAGGTTTACTTAAAAAAGGTTGTTCAGTTTCAGGATCTGATTTAGTTAAAAATGATGAAACTAA
AAAATTGGAAAAATTAGGTGTAGAAATTTTTTCTTCTCAAGTTCGCCAAAATATTGAATTTGTGATTTCGAAATTTACCA
ACAAATTGATTAATTTTGTTGTAAGCTCTGCGATCAAACCAGAAAATGAAGAATTTTCGTACTGCAGAGAAAAAAATTTA
TCAATAAAACATCGTTCAGAGATACTTGCAATGCTAATGCGTACTTATACTTCATTCGCGGTAGCCGGCAGCCACGGGAA
AACATCAACCAGTACATTTCTATCTACAATACTTGAATTATGTACACGTAATTCTTCTTCAATAACTGGAGGAATAATTC
CTATTTACAACTCTAATTGTCATTTAGAAAATACAAAATACTTAGTAGCTGAAGTTGATGAATCGGATGGAACAATTAAC
AAATATAAGTCTGATATCGGAATAATCAATAACATTGATTTTGATCATTGCGATCACTTTTCTAATTTAAGTGAAGTCAT
ATGTTCATTTAATAGTTTCGCTAAAAACTCGAAAAAATTACTGCTTAATTTTGATTGTGAAACCTCAAGCAATAATTTTT
ATTCTAATTTTAAGTGGTCAAACACTACAGCTAAAAACGTAACTTATGCAATAATTCCGACTGAAATTAATGCGAGATAT
ACAATTGGAAAATATTATGAAAATGGAAATCTTATTGGTAGTTTAAAAATTCCAATTCCAGGGTTACACAATCTATCTAA
TATCACCGCAGCAATAGCAGCTTCAAGAATGATAGGAGTAGATTTTATAGAAATTAAGAAAAATATAAAATATCTGAAAC
TCCCAAAAAAAAGATTTGAATTCAGAGGTCAAATAGATGAAAGAAGTTTATATGATGATTATGCACATCACCCAAATGAA
ATAAAAGAGACGATTAAATTAGGAAGATTATTGATTCAGCAAAAACATAATAATGAATGTCAACAAAGAAGATTAATAGC
TATATTTCAACCTCATAGATACTCTCGAGTAAAGCAATTTACTAAAGAATTCGCTGAAGAATTATCAAAGGCAGATGTTA
TTTATGTAACCAGTATTTATGGAGCAGGGGAAGGAAACGAAGAAAAAATTACTTCGAAAATGATCACTGATTTGATTTAT
AAAAAAAACGAAAATGTTAGTTACATAAATAATTATTATGAAGTTACAAAGAATTTTTACGAATTAACTCAAAAAGGGGA
TTTAATTTTGAATATGGGAGCCGGTGATTGTCATATTCTCTGGTCAATTTTAAATGAAAAAAACAATTAA

Upstream 100 bases:

>100_bases
TTTACCTAGAAGTTATTTTGATTTAAGTAAAAGATAAACATTGGATAAAAAATTACTGTTGAAAAGTCATTTTCATTTTA
TTGGGATTGGAGGTATTGGG

Downstream 100 bases:

>100_bases
ATTAGATAACTAATTTATGAATAAAAAAAATTTTTTTGAAAACTGTAATTTAAGTAGTTATACAACTATAAAAGTGGGTG
GAATAGCTGAATATTTTGCT

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSALAIGLLKKGCSVSGSDLVKNDETKKLEKLGVEIFSSQVRQNIEFVISKFTNKLINFVVSSAIKPENEEFSYCREKNL
SIKHRSEILAMLMRTYTSFAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLENTKYLVAEVDESDGTIN
KYKSDIGIINNIDFDHCDHFSNLSEVICSFNSFAKNSKKLLLNFDCETSSNNFYSNFKWSNTTAKNVTYAIIPTEINARY
TIGKYYENGNLIGSLKIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQIDERSLYDDYAHHPNE
IKETIKLGRLLIQQKHNNECQQRRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEEKITSKMITDLIY
KKNENVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHILWSILNEKNN

Sequences:

>Translated_449_residues
MSALAIGLLKKGCSVSGSDLVKNDETKKLEKLGVEIFSSQVRQNIEFVISKFTNKLINFVVSSAIKPENEEFSYCREKNL
SIKHRSEILAMLMRTYTSFAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLENTKYLVAEVDESDGTIN
KYKSDIGIINNIDFDHCDHFSNLSEVICSFNSFAKNSKKLLLNFDCETSSNNFYSNFKWSNTTAKNVTYAIIPTEINARY
TIGKYYENGNLIGSLKIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQIDERSLYDDYAHHPNE
IKETIKLGRLLIQQKHNNECQQRRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEEKITSKMITDLIY
KKNENVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHILWSILNEKNN
>Mature_448_residues
SALAIGLLKKGCSVSGSDLVKNDETKKLEKLGVEIFSSQVRQNIEFVISKFTNKLINFVVSSAIKPENEEFSYCREKNLS
IKHRSEILAMLMRTYTSFAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLENTKYLVAEVDESDGTINK
YKSDIGIINNIDFDHCDHFSNLSEVICSFNSFAKNSKKLLLNFDCETSSNNFYSNFKWSNTTAKNVTYAIIPTEINARYT
IGKYYENGNLIGSLKIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQIDERSLYDDYAHHPNEI
KETIKLGRLLIQQKHNNECQQRRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEEKITSKMITDLIYK
KNENVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHILWSILNEKNN

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=453, Percent_Identity=27.3730684326711, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790680, Length=404, Percent_Identity=25.2475247524752, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51065; Mature: 50934

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALAIGLLKKGCSVSGSDLVKNDETKKLEKLGVEIFSSQVRQNIEFVISKFTNKLINFV
CCHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSSAIKPENEEFSYCREKNLSIKHRSEILAMLMRTYTSFAVAGSHGKTSTSTFLSTILEL
HHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHH
CTRNSSSITGGIIPIYNSNCHLENTKYLVAEVDESDGTINKYKSDIGIINNIDFDHCDHF
HCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCEECCCHHHHHHH
SNLSEVICSFNSFAKNSKKLLLNFDCETSSNNFYSNFKWSNTTAKNVTYAIIPTEINARY
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCEE
TIGKYYENGNLIGSLKIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFE
EEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCHHHHH
FRGQIDERSLYDDYAHHPNEIKETIKLGRLLIQQKHNNECQQRRLIAIFQPHRYSRVKQF
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCHHHHHHHH
TKEFAEELSKADVIYVTSIYGAGEGNEEKITSKMITDLIYKKNENVSYINNYYEVTKNFY
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ELTQKGDLILNMGAGDCHILWSILNEKNN
HHHCCCCEEEEECCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SALAIGLLKKGCSVSGSDLVKNDETKKLEKLGVEIFSSQVRQNIEFVISKFTNKLINFV
CHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSSAIKPENEEFSYCREKNLSIKHRSEILAMLMRTYTSFAVAGSHGKTSTSTFLSTILEL
HHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHH
CTRNSSSITGGIIPIYNSNCHLENTKYLVAEVDESDGTINKYKSDIGIINNIDFDHCDHF
HCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCEECCCHHHHHHH
SNLSEVICSFNSFAKNSKKLLLNFDCETSSNNFYSNFKWSNTTAKNVTYAIIPTEINARY
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEEECCCCCEE
TIGKYYENGNLIGSLKIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFE
EEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCHHHHH
FRGQIDERSLYDDYAHHPNEIKETIKLGRLLIQQKHNNECQQRRLIAIFQPHRYSRVKQF
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCHHHHHHHH
TKEFAEELSKADVIYVTSIYGAGEGNEEKITSKMITDLIYKKNENVSYINNYYEVTKNFY
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ELTQKGDLILNMGAGDCHILWSILNEKNN
HHHCCCCEEEEECCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]