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The map label for this gene is argH [H]

Identifier: 123967548

GI number: 123967548

Start: 14527

End: 15906

Strand: Direct

Name: argH [H]

Synonym: A9601_00111

Alternate gene names: 123967548

Gene position: 14527-15906 (Clockwise)

Preceding gene: 123967547

Following gene: 123967549

Centisome position: 0.87

GC content: 32.39

Gene sequence:

>1380_bases
ATGGCAAAAGTTTGGAGTAAAAGGTTTGATAATGCACTTGACACTTTTATTGAAAAGTTTAATGCTTCAATATTTTTTGA
TAGAAAGCTTATTTTAGAAGATTTAGATTGTTCGATTGCTCATGCGAAAATGCTTGGCAAAACAGAAGTATTATCCTCGA
CTGAAGCTTTACAAATTATAAATGGTTTAGAGTCAATAAAAGTTGACTATTTGGAAGGTAAATTTTCTCCTGGTCCACCT
TCAGAAGATATTCACTATTGCATTGAAGAAAAGCTAATCAGTTTAATTGGTGAAACTGGAAAAAAATTACATACAGGTAG
AAGTAGAAATGATCAAGTTGGCACAGATTTAAGATTGTGGCTAAGAAAAGAAATTGACAATAATGAAATTCTAATAACCG
ATTTGCAAAAATCCTTCTTAAATCTCGCGAAATCCAATATTTACACCTTAATTCCTGGATATACTCATATGCAAAGAGCT
CAACCATTATCTTTGGCTCATCATTTATTGGCTTATATAGAAATGCTCCAAAGAGACCGCGAAAGGTTTAAAGAAGTACG
CTTAAGAGTAAATACTTCGCCGTTAGGAGCTGCAGCATTAGCTGGAACAAAAATAAAAATAGATAGGCACTTTACAGCTG
CAGAATTGGGTTTTGAAAAAATTTATAAAAATAGTATTGATGCAGTTAGTGACAGAGATTTTTGTATAGAGTTTGTTTCT
GCATCTGCCTTGTTGATGTCGCATTTAAGTAAAATTTCAGAGGAAATAATTTTATGGGTAACTGATGAATTTTCTTTTGC
GAAATTAACAGATAAATGTGCAACGGGAAGTAGCTTAATGCCGCAGAAAAAAAATCCTGACGTTCCAGAATTGATAAGAG
GTAAGACAGGAAGAGTGTATGGACATCTCCAGGCATTGTTAACGATGGTCAAAGGAGTACCACTTTCATACAATAAGGAT
TTTCAGGAAGATAAAGAGCCAATATTTGATACTGCAGAAACAATATCGTCTTGTATTAAAGCAATGACTATTTTAATTAA
TCAGGGTATTGAATTTAATGTTAAAAATCTATCTGATTCTGTAGAAAACGACTTTTCTAATGCTACCGACTTGGCAGATT
ACTTAGTGGGTAAAGATGTCCCTTTTAGGACCGCCTATCAAGTTGTTGGTGAAATAGTCAAATATTGCCTAGAGAGAAAA
ATATTATTTAAAAATCTCAAAATTAATGAATTTAAAAAATTTCATCCCAAATTTGATGAGGATGTTTTTCTGGATCTTAA
GCCTTTTAATGTCGTTAAATCAAGAAATAGCGAAGGAGGTACAGGTTTTGTTCAGGTAGAAAAAGAGGTTAATAATTGGC
AAAAAAAATTGTTACTTTGA

Upstream 100 bases:

>100_bases
GAAGATGACGCCTCGATGGTTATTTTTCAATTGAAATAGATATTTTTGTCACACACATAAAAAAATGCTTTATTAGAGAT
ACTTAAAGTTAATTATTGAT

Downstream 100 bases:

>100_bases
ATCTAAATTATTTTTCTACAACAAGGGTATACTTTGAAGTAGAATAGTAAAGCAACGATCTGGGACTACTTATTGTAGTT
TTTTTATAAGGTAATTTTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAKVWSKRFDNALDTFIEKFNASIFFDRKLILEDLDCSIAHAKMLGKTEVLSSTEALQIINGLESIKVDYLEGKFSPGPP
SEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNNEILITDLQKSFLNLAKSNIYTLIPGYTHMQRA
QPLSLAHHLLAYIEMLQRDRERFKEVRLRVNTSPLGAAALAGTKIKIDRHFTAAELGFEKIYKNSIDAVSDRDFCIEFVS
ASALLMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGHLQALLTMVKGVPLSYNKD
FQEDKEPIFDTAETISSCIKAMTILINQGIEFNVKNLSDSVENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLERK
ILFKNLKINEFKKFHPKFDEDVFLDLKPFNVVKSRNSEGGTGFVQVEKEVNNWQKKLLL

Sequences:

>Translated_459_residues
MAKVWSKRFDNALDTFIEKFNASIFFDRKLILEDLDCSIAHAKMLGKTEVLSSTEALQIINGLESIKVDYLEGKFSPGPP
SEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNNEILITDLQKSFLNLAKSNIYTLIPGYTHMQRA
QPLSLAHHLLAYIEMLQRDRERFKEVRLRVNTSPLGAAALAGTKIKIDRHFTAAELGFEKIYKNSIDAVSDRDFCIEFVS
ASALLMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGHLQALLTMVKGVPLSYNKD
FQEDKEPIFDTAETISSCIKAMTILINQGIEFNVKNLSDSVENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLERK
ILFKNLKINEFKKFHPKFDEDVFLDLKPFNVVKSRNSEGGTGFVQVEKEVNNWQKKLLL
>Mature_458_residues
AKVWSKRFDNALDTFIEKFNASIFFDRKLILEDLDCSIAHAKMLGKTEVLSSTEALQIINGLESIKVDYLEGKFSPGPPS
EDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNNEILITDLQKSFLNLAKSNIYTLIPGYTHMQRAQ
PLSLAHHLLAYIEMLQRDRERFKEVRLRVNTSPLGAAALAGTKIKIDRHFTAAELGFEKIYKNSIDAVSDRDFCIEFVSA
SALLMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGHLQALLTMVKGVPLSYNKDF
QEDKEPIFDTAETISSCIKAMTILINQGIEFNVKNLSDSVENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLERKI
LFKNLKINEFKKFHPKFDEDVFLDLKPFNVVKSRNSEGGTGFVQVEKEVNNWQKKLLL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=42.350332594235, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=42.350332594235, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=40.1330376940133, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=39.4678492239468, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1790398, Length=460, Percent_Identity=42.8260869565217, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=40.8695652173913, Blast_Score=332, Evalue=1e-91,
Organism=Drosophila melanogaster, GI221473854, Length=440, Percent_Identity=38.4090909090909, Blast_Score=331, Evalue=8e-91,
Organism=Drosophila melanogaster, GI78706858, Length=440, Percent_Identity=38.4090909090909, Blast_Score=331, Evalue=8e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52162; Mature: 52030

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVWSKRFDNALDTFIEKFNASIFFDRKLILEDLDCSIAHAKMLGKTEVLSSTEALQII
CCCHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NGLESIKVDYLEGKFSPGPPSEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLW
HHHHHHEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHH
LRKEIDNNEILITDLQKSFLNLAKSNIYTLIPGYTHMQRAQPLSLAHHLLAYIEMLQRDR
HHHHCCCCCEEEEHHHHHHHHHHHCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFKEVRLRVNTSPLGAAALAGTKIKIDRHFTAAELGFEKIYKNSIDAVSDRDFCIEFVS
HHHHHHHEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ASALLMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVY
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GHLQALLTMVKGVPLSYNKDFQEDKEPIFDTAETISSCIKAMTILINQGIEFNVKNLSDS
HHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
VENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLERKILFKNLKINEFKKFHPKFDE
HHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DVFLDLKPFNVVKSRNSEGGTGFVQVEKEVNNWQKKLLL
CEEEECCCHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
AKVWSKRFDNALDTFIEKFNASIFFDRKLILEDLDCSIAHAKMLGKTEVLSSTEALQII
CCHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NGLESIKVDYLEGKFSPGPPSEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLW
HHHHHHEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHH
LRKEIDNNEILITDLQKSFLNLAKSNIYTLIPGYTHMQRAQPLSLAHHLLAYIEMLQRDR
HHHHCCCCCEEEEHHHHHHHHHHHCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFKEVRLRVNTSPLGAAALAGTKIKIDRHFTAAELGFEKIYKNSIDAVSDRDFCIEFVS
HHHHHHHEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ASALLMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVY
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GHLQALLTMVKGVPLSYNKDFQEDKEPIFDTAETISSCIKAMTILINQGIEFNVKNLSDS
HHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
VENDFSNATDLADYLVGKDVPFRTAYQVVGEIVKYCLERKILFKNLKINEFKKFHPKFDE
HHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DVFLDLKPFNVVKSRNSEGGTGFVQVEKEVNNWQKKLLL
CEEEECCCHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA