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The map label for this gene is atpB

Identifier: 121999214

GI number: 121999214

Start: 2675388

End: 2676188

Strand: Reverse

Name: atpB

Synonym: Hhal_2436

Alternate gene names: 121999214

Gene position: 2676188-2675388 (Counterclockwise)

Preceding gene: 121999215

Following gene: 121999213

Centisome position: 99.92

GC content: 60.3

Gene sequence:

>801_bases
ATGAGCGCCGACAGCGAGTTCGACGCGACGGACTACATCCAGCACCACCTCACCAACCTTCGCCTGGACCTGACCGAGGG
TACGATCGATTCGGAAGCCACCGGCTTCTGGACGCTCCACATCGATACCCTGATCATGTCGTTCGGTCTCGGTGCGTTGT
TCTGCTACGTCTTCTGGCTGGCCGCCCGCCAGGCCACACCGGGCGTACCGGGTGGGCTGCAGAACTTCGTCGAGGCCATG
ATCGAGTTCATCGACAAGACGGTGAAGGAGACCTTCCACGCGAAGAGCAAGGTCATCGCGCCGCTGGCGCTGACCATCTT
CTGCTGGGTCTTCCTGTCAAACCTGATGGACCTTGTGCCGATCGACATGGTGCCGAGCATCATGATGGCCGTGGGAGTGG
ATTACTGGAAGATCCTTCCCAGTGTCGACCTGAACTTCACCTTCGGCCTGTCCCTGAGCGTGCTGGCGCTGATCATCATC
TACGGCGTGATGGGTCAGGGCGTTGGCGGCTGGCTCAAGAGCTGGGTGACCCACCCGCTGGGCCCCTGGCTTGCGCCGGC
CAACCTGATCCTGAACATCGTGGAGTTCATCGCCAAGCCGGTGTCGCTCTCACTGCGACTGTTCGGCAACCTCTACGCCG
CAGAGCTGGTCTTTATCCTGATCTCTCTGCTGCCGTGGTGGATCCAGTGGGCGCTCGGTACCCCCTGGGCGATCTTCCAC
ATCCTGGTCGTGCCGCTTCAGGCCTTCATCTTCATGATGCTCACCGTGGTCTATCTGGCCATGGCGTATGAAGAACATTA
A

Upstream 100 bases:

>100_bases
AACGTACGCAGCCGCCTTAGGCACCTACTGGTTCTTCTTCTTGGGGGCCCTCCGTACCTAGCGCATCCGCGCGGTACCAA
ACCGGGGAGCAACGTTTGCC

Downstream 100 bases:

>100_bases
ACTGCCTCACTTTCGATACTGAGAATCCGGGAGGAATCACATGGAACTCGCAGAGCTCATTGCTAACGTCCAGGGGCTGA
CCGCCCTGACCGTGGGCATC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSADSEFDATDYIQHHLTNLRLDLTEGTIDSEATGFWTLHIDTLIMSFGLGALFCYVFWLAARQATPGVPGGLQNFVEAM
IEFIDKTVKETFHAKSKVIAPLALTIFCWVFLSNLMDLVPIDMVPSIMMAVGVDYWKILPSVDLNFTFGLSLSVLALIII
YGVMGQGVGGWLKSWVTHPLGPWLAPANLILNIVEFIAKPVSLSLRLFGNLYAAELVFILISLLPWWIQWALGTPWAIFH
ILVVPLQAFIFMMLTVVYLAMAYEEH

Sequences:

>Translated_266_residues
MSADSEFDATDYIQHHLTNLRLDLTEGTIDSEATGFWTLHIDTLIMSFGLGALFCYVFWLAARQATPGVPGGLQNFVEAM
IEFIDKTVKETFHAKSKVIAPLALTIFCWVFLSNLMDLVPIDMVPSIMMAVGVDYWKILPSVDLNFTFGLSLSVLALIII
YGVMGQGVGGWLKSWVTHPLGPWLAPANLILNIVEFIAKPVSLSLRLFGNLYAAELVFILISLLPWWIQWALGTPWAIFH
ILVVPLQAFIFMMLTVVYLAMAYEEH
>Mature_265_residues
SADSEFDATDYIQHHLTNLRLDLTEGTIDSEATGFWTLHIDTLIMSFGLGALFCYVFWLAARQATPGVPGGLQNFVEAMI
EFIDKTVKETFHAKSKVIAPLALTIFCWVFLSNLMDLVPIDMVPSIMMAVGVDYWKILPSVDLNFTFGLSLSVLALIIIY
GVMGQGVGGWLKSWVTHPLGPWLAPANLILNIVEFIAKPVSLSLRLFGNLYAAELVFILISLLPWWIQWALGTPWAIFHI
LVVPLQAFIFMMLTVVYLAMAYEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=270, Percent_Identity=52.2222222222222, Blast_Score=256, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_HALHL (A1WZT7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001004001.1
- ProteinModelPortal:   A1WZT7
- SMR:   A1WZT7
- STRING:   A1WZT7
- GeneID:   4709450
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2436
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   AGELVFM
- PhylomeDB:   A1WZT7
- ProtClustDB:   PRK05815
- BioCyc:   HHAL349124:HHAL_2436-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 29758; Mature: 29626

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1cf3b33c)-; HASH(0x1c22c240)-; HASH(0x1c3e1a50)-; HASH(0x1b75c050)-; HASH(0x1ce13bb8)-; HASH(0x1bd0184c)-; HASH(0x1ceddd2c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SADSEFDATDYIQHHLTNLRLDLTEGTIDSEATGFWTLHIDTLIMSFGLGALFCYVFWL
CCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
AARQATPGVPGGLQNFVEAMIEFIDKTVKETFHAKSKVIAPLALTIFCWVFLSNLMDLVP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDMVPSIMMAVGVDYWKILPSVDLNFTFGLSLSVLALIIIYGVMGQGVGGWLKSWVTHPL
HHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GPWLAPANLILNIVEFIAKPVSLSLRLFGNLYAAELVFILISLLPWWIQWALGTPWAIFH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILVVPLQAFIFMMLTVVYLAMAYEEH
HHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA