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The map label for this gene is atpA

Identifier: 121999210

GI number: 121999210

Start: 2672442

End: 2673983

Strand: Reverse

Name: atpA

Synonym: Hhal_2432

Alternate gene names: 121999210

Gene position: 2673983-2672442 (Counterclockwise)

Preceding gene: 121999211

Following gene: 121999209

Centisome position: 99.83

GC content: 65.95

Gene sequence:

>1542_bases
ATGCAAGTCAATCCATCGGAGATCAGCGAGCTCATCAAGCGTCGCATTGAGAACTTCGACGCGGCGGCTGAGGCCCGCAA
CGAAGGCACCGTCGTCAGCGTTGGCGACGGCATCTGCCGCATCCACGGCCTCGCCGACGTCATGTTCGGCGAGATGCTGG
AGTTCCCTGACGACACCTTCGGCATGGCCCTGAACCTTGAGCGGGACTCCGTCGGTGCCGTCCTCCTCGGTGACTACCAG
CACATCAAGGAGGGGGCCACCGTCAAGTGCACCGGCCGCATCCTGGAGGTGCCGGTTGGTGACGCCATGCTCGGCCGCGT
GGTCGACGCCCTGGGTCGCCCCACCGACGGCAAGGGCCCGATCAAGACCGAGGGCAGCGAGCCCATCGAGAAGGTGGCGC
CGGGCGTCATCACCCGCGAAGGGGTCGACCAGCCGGTCCAGACCGGCCTCAAGGCCATCGACTCCATGGTGCCGATCGGC
CGCGGTCAGCGTGAGCTGATCATCGGCGACCGCCAGACCGGCAAGACCGCGGTGGCCGTCGACGCGATCATCAACCAGAA
GGACAGCGGCATTAAGTGCATCTACGTCGCGGTCGGGCAGAAGAACTCGACGGTCGCCAACGTGGTGCGCAAGCTCGAGG
AGCACGGCGCGATGGACAACACCATCGTCGTTAACGCCGGCGCCTCCGAGTCCGCCGCCATGCAGTACATCGCCCCCTAC
GCCGGCTGCGCCATGGGCGAGTACTTCCGCGATCGCGGCCAGGACGCCCTGATCATCTACGACGACCTGACCAAGCAGGC
CTGGGCCTATCGTCAGGTGTCGCTGCTGCTGCGCCGTCCCCCGGGCCGTGAGGCCTATCCGGGTGATGTCTTCTACCTCC
ACTCGCGGCTGCTCGAGCGCGCCTCGCGCATCAACGCCGAGGAGGTGGAGCGTCGGACCAACGGCGAGGTCAAGGGCCAG
ACCGGTTCGCTGACCGCGCTGCCGATCATTGAGACCCAGGCCGGCGACGTCTCCGCCTTCGTGCCGACCAACGTGATCTC
GATCACCGACGGCCAGATCTACCTCGAGACCGACCTGTTCAACTCCGGTGTCCGCCCCGCGGTCAACGCCGGTCTGTCGG
TCTCCCGCGTGGGTGGTTCGGCGCAGACGAAGATCATCAAGAAGCTCGGCGGCGGTGTTCGCCTGGCCCTCGCCCAGTAC
CGGGAGCTGGCTGCCTTCTCGCAGTTCGCCTCGGATCTGGACGAGACCACCCGGCAGCAGCTCGAGCGCGGTAAGCGCAC
CATGGAGCTGATGAAGCAGGGTCAGTACGAGCCGCAGTCGGTCGGCGAGATGGCCTTCGTGCTGTTCGCCGCCAACGAGG
GCTACGTCGACGACGTCGAGAACGACCAGGTGGTCCGTTTCGAGAAGGCGCTGCTCGACTACCTGCGTGCGGAGCACGCC
GAGCTGCTCCAGCGCATCACGGAGACCGGCGATTACAACGACGAGATCCACGCCGAGATGCAGAAGGCGATGGATGCGTT
CAAGAAGAATCGCACGTGGTGA

Upstream 100 bases:

>100_bases
CGGGGCGATGATCCGCGCTGGCGACACCACCATAGACGGCTCGGTGAAGGGCAAACTGGCCCGCCTCTCGAGTGCACTGG
TTCATTGACGAGGTAGGACG

Downstream 100 bases:

>100_bases
GCATGCGCTGCCGGGGAGCCGGGTGCTCCCCGGCCGGCCCCTTAACGACACATAGGTGACGGCATGGCCGGGGCGAAAGA
AGTCAAGACCAAGATCAAGA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQVNPSEISELIKRRIENFDAAAEARNEGTVVSVGDGICRIHGLADVMFGEMLEFPDDTFGMALNLERDSVGAVLLGDYQ
HIKEGATVKCTGRILEVPVGDAMLGRVVDALGRPTDGKGPIKTEGSEPIEKVAPGVITREGVDQPVQTGLKAIDSMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKDSGIKCIYVAVGQKNSTVANVVRKLEEHGAMDNTIVVNAGASESAAMQYIAPY
AGCAMGEYFRDRGQDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERASRINAEEVERRTNGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLFNSGVRPAVNAGLSVSRVGGSAQTKIIKKLGGGVRLALAQY
RELAAFSQFASDLDETTRQQLERGKRTMELMKQGQYEPQSVGEMAFVLFAANEGYVDDVENDQVVRFEKALLDYLRAEHA
ELLQRITETGDYNDEIHAEMQKAMDAFKKNRTW

Sequences:

>Translated_513_residues
MQVNPSEISELIKRRIENFDAAAEARNEGTVVSVGDGICRIHGLADVMFGEMLEFPDDTFGMALNLERDSVGAVLLGDYQ
HIKEGATVKCTGRILEVPVGDAMLGRVVDALGRPTDGKGPIKTEGSEPIEKVAPGVITREGVDQPVQTGLKAIDSMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKDSGIKCIYVAVGQKNSTVANVVRKLEEHGAMDNTIVVNAGASESAAMQYIAPY
AGCAMGEYFRDRGQDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERASRINAEEVERRTNGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLFNSGVRPAVNAGLSVSRVGGSAQTKIIKKLGGGVRLALAQY
RELAAFSQFASDLDETTRQQLERGKRTMELMKQGQYEPQSVGEMAFVLFAANEGYVDDVENDQVVRFEKALLDYLRAEHA
ELLQRITETGDYNDEIHAEMQKAMDAFKKNRTW
>Mature_513_residues
MQVNPSEISELIKRRIENFDAAAEARNEGTVVSVGDGICRIHGLADVMFGEMLEFPDDTFGMALNLERDSVGAVLLGDYQ
HIKEGATVKCTGRILEVPVGDAMLGRVVDALGRPTDGKGPIKTEGSEPIEKVAPGVITREGVDQPVQTGLKAIDSMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKDSGIKCIYVAVGQKNSTVANVVRKLEEHGAMDNTIVVNAGASESAAMQYIAPY
AGCAMGEYFRDRGQDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERASRINAEEVERRTNGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLFNSGVRPAVNAGLSVSRVGGSAQTKIIKKLGGGVRLALAQY
RELAAFSQFASDLDETTRQQLERGKRTMELMKQGQYEPQSVGEMAFVLFAANEGYVDDVENDQVVRFEKALLDYLRAEHA
ELLQRITETGDYNDEIHAEMQKAMDAFKKNRTW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=510, Percent_Identity=55.8823529411765, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI4757810, Length=510, Percent_Identity=55.8823529411765, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI19913428, Length=318, Percent_Identity=27.9874213836478, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913426, Length=318, Percent_Identity=27.9874213836478, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI32189394, Length=387, Percent_Identity=24.031007751938, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI19913424, Length=332, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=71.3450292397661, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=308, Percent_Identity=26.9480519480519, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788251, Length=365, Percent_Identity=25.7534246575342, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=510, Percent_Identity=57.0588235294118, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71988080, Length=510, Percent_Identity=57.0588235294118, Blast_Score=578, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71988074, Length=510, Percent_Identity=52.9411764705882, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17510931, Length=387, Percent_Identity=26.0981912144703, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17570191, Length=368, Percent_Identity=26.6304347826087, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=441, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=514, Percent_Identity=54.0856031128405, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319603, Length=382, Percent_Identity=28.2722513089005, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=398, Percent_Identity=24.8743718592965, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24658560, Length=510, Percent_Identity=54.9019607843137, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=28.8524590163934, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=28.8524590163934, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=28.8524590163934, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24638766, Length=330, Percent_Identity=25.1515151515152, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574560, Length=321, Percent_Identity=24.9221183800623, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583992, Length=332, Percent_Identity=24.6987951807229, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583988, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583986, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583984, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_HALHL (A1WZT3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003997.1
- ProteinModelPortal:   A1WZT3
- SMR:   A1WZT3
- STRING:   A1WZT3
- GeneID:   4710557
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2432
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   A1WZT3
- ProtClustDB:   PRK09281
- BioCyc:   HHAL349124:HHAL_2432-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 56063; Mature: 56063

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVNPSEISELIKRRIENFDAAAEARNEGTVVSVGDGICRIHGLADVMFGEMLEFPDDTF
CCCCHHHHHHHHHHHHHCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
GMALNLERDSVGAVLLGDYQHIKEGATVKCTGRILEVPVGDAMLGRVVDALGRPTDGKGP
CEEEEECCCCCCEEEECCHHHHHCCCEEEEECEEEECCCCHHHHHHHHHHHCCCCCCCCC
IKTEGSEPIEKVAPGVITREGVDQPVQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVAV
CCCCCCCCHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHEEH
DAIINQKDSGIKCIYVAVGQKNSTVANVVRKLEEHGAMDNTIVVNAGASESAAMQYIAPY
HHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
AGCAMGEYFRDRGQDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRINAEEVERRTNGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLF
HHCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NSGVRPAVNAGLSVSRVGGSAQTKIIKKLGGGVRLALAQYRELAAFSQFASDLDETTRQQ
CCCCCHHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERGKRTMELMKQGQYEPQSVGEMAFVLFAANEGYVDDVENDQVVRFEKALLDYLRAEHA
HHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELLQRITETGDYNDEIHAEMQKAMDAFKKNRTW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQVNPSEISELIKRRIENFDAAAEARNEGTVVSVGDGICRIHGLADVMFGEMLEFPDDTF
CCCCHHHHHHHHHHHHHCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
GMALNLERDSVGAVLLGDYQHIKEGATVKCTGRILEVPVGDAMLGRVVDALGRPTDGKGP
CEEEEECCCCCCEEEECCHHHHHCCCEEEEECEEEECCCCHHHHHHHHHHHCCCCCCCCC
IKTEGSEPIEKVAPGVITREGVDQPVQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVAV
CCCCCCCCHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHEEH
DAIINQKDSGIKCIYVAVGQKNSTVANVVRKLEEHGAMDNTIVVNAGASESAAMQYIAPY
HHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
AGCAMGEYFRDRGQDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRINAEEVERRTNGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLF
HHCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NSGVRPAVNAGLSVSRVGGSAQTKIIKKLGGGVRLALAQYRELAAFSQFASDLDETTRQQ
CCCCCHHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERGKRTMELMKQGQYEPQSVGEMAFVLFAANEGYVDDVENDQVVRFEKALLDYLRAEHA
HHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELLQRITETGDYNDEIHAEMQKAMDAFKKNRTW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA