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The map label for this gene is glmS [H]

Identifier: 121999204

GI number: 121999204

Start: 2665520

End: 2667349

Strand: Reverse

Name: glmS [H]

Synonym: Hhal_2426

Alternate gene names: 121999204

Gene position: 2667349-2665520 (Counterclockwise)

Preceding gene: 121999205

Following gene: 121999203

Centisome position: 99.59

GC content: 70.93

Gene sequence:

>1830_bases
ATGTGCGGGATTGTCGGTGCTTGTGCGCAGCGTGATGTTGCCCCGGTCCTCCTCGAAGGCCTGAGGCGCCTGGAATACCG
GGGATATGATTCGGCCGGGATGGCCGTGATCGATGCCGACGGCCACCTATCGCGGACCCGGGTGGCGGGCCGGGTGGATG
ACCTGGCCAGCGTCCTCGAGCCGCAGCTGCCGGCCGGCGGCACGGGCATCGCCCACACCCGCTGGGCCACCCACGGCGTG
CCCAACGACGTCAACGCCCATCCGCACACCGCCGCCGGCGAGGTGGCGCTGGTCCATAACGGCATTATCGAGAACCACGA
GCGCCTGCGCGAGCGCCTGGAGGCGGCCGGCTACCGCTTCCAGTCCGAGACGGACACCGAGGTCGCCGTCACGCTCTTCG
CCGATCGGCACAGCCGGGGTGCCGATCTGTTCGCCGCGGTGCAGGGCGGGCTATCGGAACTCGAGGGGGCCTACGCCTTC
GCCGTCGTTTCGGCCCGCGAGCCCGGGCGGATGATCGCCTGCCGCCGCGGCAGCCCCCTGGTTATCGGCGTTGGCATCGG
CGAGCACTTCGTGGCCTCGGACGTCGCCGCGCTGCTGCCGGTCACCCGCCAGTTCATCTTCCTTGAGGACGGCGATGTCG
CCGATATCCACCGCGACGGCGTGGCCATCTACGACGCCGATGGCCATACCGTCGAGCGGCCGGTCCGCGTATCGGAACTC
AGTGCCGAGTCTGTGGAGCGGGGTGGCTACCGCCACTTCATGCTCAAGGAGATCCACGAGCAGCCCGCTGCCGTGGCCGA
GACCCTGGAGGGCCGTCACGCCGACGGTCGTGTCCTCGAGGCCGCCTTCGGCCCTGGCGCCGAGCAGCTCCTCGACCAGG
CCGAGCGCCTGCAGATCGTGGCCTGCGGCACCTCCTACCACGCCGGGCTGATCGCCCGGTTCTGGGCCGAGACCTACGCC
GGCCTGCCCTGCGATGTCGAGGTGGCGAGCGAATTCCGCTACCGGGCGCACGCCGTCACGCCGGGGACCCTGGTGGTGGT
CATCTCGCAATCCGGCGAGACCGCCGACGTCCTGGCCGCCCTGCGCGAGTCGCGCCGGCTCGGCTACGCCGGTGTGCTGG
CCATCTGCAATGTCCCCGAGAGTTCCCTGGTGCGCGAGGCCGACCTGACCCTGCTCACCCGGGCCGGGCCGGAGATTGGC
GTCGCCTCCACGAAGGCGTTCACCACGCAGCTGACCGCGCTGCTGCTGCTGGTTGCCGCCTTCGCCCGGCGCCGCGGGCG
GCCCCAGTCCGAGCAGGAACTGGTTCGCGCCGCCGTGCAGCTGCCCGGCGCCCTGGAGCGGGCCGTTGCCGTCGAGGCCC
AGGTGGCCGAGCTGGCTGAGCAGTTCGTCGACCGAGCCCACGCCCTGTTCCTCGGGCGCGGCGCGCACTACCCGGTGGCC
CTCGAGGGCTCGCTTAAGCTCAAGGAGATCTCCTACATCCACGCCGAGGCCTACCCGGCCGGCGAGCTCAAGCACGGCCC
GCTGGCCCTGGTCGACGACGGCATGCCGGTGGTGGCCGTCGCCCCACGGGACGATCTGCTCGACAAGCTGCAGTCGAACC
TCCAGGAAGTCCGCGCCCGCGGGGGACGCCTGTTCGTCTTCGCCGACGACGCCGCAGCACTGCGTTCCACGGGTGGCTAC
CAAGTGTTGCCCGTTCCTGCGGGCCCGGACCCCATCTCGCCGGTGATCCACACCGTCCCGCTACAGCTGCTCGCCTACCA
CGTGGCCGTGCTGCGCGGCACGGATGTCGACAAGCCGCGCAATCTGGCCAAGTCGGTCACCGTCGAATGA

Upstream 100 bases:

>100_bases
CGGGACCTCGCCTTGGGTAGTACCGCGCAGCAGGTCTGCCGTAACTGCCCCTGCTCGGTGCTGCTGGTGCCCAACGAGCA
AGGGATCTGGATCCGCTGAT

Downstream 100 bases:

>100_bases
CAGGACCCGCCACATGAACCTGCGCGACCTCCGCTACCTGGTCGCCGTGGCCGAACACCGCCACTTCGGGCGGGCGGCCC
GCGCCTGCTATGTCAGCCAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGACAQRDVAPVLLEGLRRLEYRGYDSAGMAVIDADGHLSRTRVAGRVDDLASVLEPQLPAGGTGIAHTRWATHGV
PNDVNAHPHTAAGEVALVHNGIIENHERLRERLEAAGYRFQSETDTEVAVTLFADRHSRGADLFAAVQGGLSELEGAYAF
AVVSAREPGRMIACRRGSPLVIGVGIGEHFVASDVAALLPVTRQFIFLEDGDVADIHRDGVAIYDADGHTVERPVRVSEL
SAESVERGGYRHFMLKEIHEQPAAVAETLEGRHADGRVLEAAFGPGAEQLLDQAERLQIVACGTSYHAGLIARFWAETYA
GLPCDVEVASEFRYRAHAVTPGTLVVVISQSGETADVLAALRESRRLGYAGVLAICNVPESSLVREADLTLLTRAGPEIG
VASTKAFTTQLTALLLLVAAFARRRGRPQSEQELVRAAVQLPGALERAVAVEAQVAELAEQFVDRAHALFLGRGAHYPVA
LEGSLKLKEISYIHAEAYPAGELKHGPLALVDDGMPVVAVAPRDDLLDKLQSNLQEVRARGGRLFVFADDAAALRSTGGY
QVLPVPAGPDPISPVIHTVPLQLLAYHVAVLRGTDVDKPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGACAQRDVAPVLLEGLRRLEYRGYDSAGMAVIDADGHLSRTRVAGRVDDLASVLEPQLPAGGTGIAHTRWATHGV
PNDVNAHPHTAAGEVALVHNGIIENHERLRERLEAAGYRFQSETDTEVAVTLFADRHSRGADLFAAVQGGLSELEGAYAF
AVVSAREPGRMIACRRGSPLVIGVGIGEHFVASDVAALLPVTRQFIFLEDGDVADIHRDGVAIYDADGHTVERPVRVSEL
SAESVERGGYRHFMLKEIHEQPAAVAETLEGRHADGRVLEAAFGPGAEQLLDQAERLQIVACGTSYHAGLIARFWAETYA
GLPCDVEVASEFRYRAHAVTPGTLVVVISQSGETADVLAALRESRRLGYAGVLAICNVPESSLVREADLTLLTRAGPEIG
VASTKAFTTQLTALLLLVAAFARRRGRPQSEQELVRAAVQLPGALERAVAVEAQVAELAEQFVDRAHALFLGRGAHYPVA
LEGSLKLKEISYIHAEAYPAGELKHGPLALVDDGMPVVAVAPRDDLLDKLQSNLQEVRARGGRLFVFADDAAALRSTGGY
QVLPVPAGPDPISPVIHTVPLQLLAYHVAVLRGTDVDKPRNLAKSVTVE
>Mature_609_residues
MCGIVGACAQRDVAPVLLEGLRRLEYRGYDSAGMAVIDADGHLSRTRVAGRVDDLASVLEPQLPAGGTGIAHTRWATHGV
PNDVNAHPHTAAGEVALVHNGIIENHERLRERLEAAGYRFQSETDTEVAVTLFADRHSRGADLFAAVQGGLSELEGAYAF
AVVSAREPGRMIACRRGSPLVIGVGIGEHFVASDVAALLPVTRQFIFLEDGDVADIHRDGVAIYDADGHTVERPVRVSEL
SAESVERGGYRHFMLKEIHEQPAAVAETLEGRHADGRVLEAAFGPGAEQLLDQAERLQIVACGTSYHAGLIARFWAETYA
GLPCDVEVASEFRYRAHAVTPGTLVVVISQSGETADVLAALRESRRLGYAGVLAICNVPESSLVREADLTLLTRAGPEIG
VASTKAFTTQLTALLLLVAAFARRRGRPQSEQELVRAAVQLPGALERAVAVEAQVAELAEQFVDRAHALFLGRGAHYPVA
LEGSLKLKEISYIHAEAYPAGELKHGPLALVDDGMPVVAVAPRDDLLDKLQSNLQEVRARGGRLFVFADDAAALRSTGGY
QVLPVPAGPDPISPVIHTVPLQLLAYHVAVLRGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=37.2262773722628, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=37.3546511627907, Blast_Score=406, Evalue=1e-113,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=59.0163934426229, Blast_Score=726, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=232, Percent_Identity=30.1724137931034, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=40.6032482598608, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=39.4431554524362, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=39.4431554524362, Blast_Score=288, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6322745, Length=720, Percent_Identity=34.8611111111111, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=29.3023255813954, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.0731707317073, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=37.0639534883721, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28573187, Length=140, Percent_Identity=35, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65087; Mature: 65087

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGACAQRDVAPVLLEGLRRLEYRGYDSAGMAVIDADGHLSRTRVAGRVDDLASVLE
CCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
PQLPAGGTGIAHTRWATHGVPNDVNAHPHTAAGEVALVHNGIIENHERLRERLEAAGYRF
CCCCCCCCCCEECCHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEE
QSETDTEVAVTLFADRHSRGADLFAAVQGGLSELEGAYAFAVVSAREPGRMIACRRGSPL
CCCCCCEEEEEEEECCCCCCCHHHHHHHCCHHHHCCCEEEEEEECCCCCCEEEEECCCCE
VIGVGIGEHFVASDVAALLPVTRQFIFLEDGDVADIHRDGVAIYDADGHTVERPVRVSEL
EEEECCCCHHHHHHHHHHHHHHEEEEEEECCCEEEECCCCEEEECCCCCEECCCCCHHHH
SAESVERGGYRHFMLKEIHEQPAAVAETLEGRHADGRVLEAAFGPGAEQLLDQAERLQIV
CHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCEEEE
ACGTSYHAGLIARFWAETYAGLPCDVEVASEFRYRAHAVTPGTLVVVISQSGETADVLAA
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCEEEEEEECCCCHHHHHHH
LRESRRLGYAGVLAICNVPESSLVREADLTLLTRAGPEIGVASTKAFTTQLTALLLLVAA
HHHHCCCCCEEEEEEECCCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
FARRRGRPQSEQELVRAAVQLPGALERAVAVEAQVAELAEQFVDRAHALFLGRGAHYPVA
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEE
LEGSLKLKEISYIHAEAYPAGELKHGPLALVDDGMPVVAVAPRDDLLDKLQSNLQEVRAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGRLFVFADDAAALRSTGGYQVLPVPAGPDPISPVIHTVPLQLLAYHVAVLRGTDVDKPR
CCEEEEEECCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGACAQRDVAPVLLEGLRRLEYRGYDSAGMAVIDADGHLSRTRVAGRVDDLASVLE
CCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
PQLPAGGTGIAHTRWATHGVPNDVNAHPHTAAGEVALVHNGIIENHERLRERLEAAGYRF
CCCCCCCCCCEECCHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEE
QSETDTEVAVTLFADRHSRGADLFAAVQGGLSELEGAYAFAVVSAREPGRMIACRRGSPL
CCCCCCEEEEEEEECCCCCCCHHHHHHHCCHHHHCCCEEEEEEECCCCCCEEEEECCCCE
VIGVGIGEHFVASDVAALLPVTRQFIFLEDGDVADIHRDGVAIYDADGHTVERPVRVSEL
EEEECCCCHHHHHHHHHHHHHHEEEEEEECCCEEEECCCCEEEECCCCCEECCCCCHHHH
SAESVERGGYRHFMLKEIHEQPAAVAETLEGRHADGRVLEAAFGPGAEQLLDQAERLQIV
CHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCEEEE
ACGTSYHAGLIARFWAETYAGLPCDVEVASEFRYRAHAVTPGTLVVVISQSGETADVLAA
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCEEEEEEECCCCHHHHHHH
LRESRRLGYAGVLAICNVPESSLVREADLTLLTRAGPEIGVASTKAFTTQLTALLLLVAA
HHHHCCCCCEEEEEEECCCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
FARRRGRPQSEQELVRAAVQLPGALERAVAVEAQVAELAEQFVDRAHALFLGRGAHYPVA
HHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEE
LEGSLKLKEISYIHAEAYPAGELKHGPLALVDDGMPVVAVAPRDDLLDKLQSNLQEVRAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGRLFVFADDAAALRSTGGYQVLPVPAGPDPISPVIHTVPLQLLAYHVAVLRGTDVDKPR
CCEEEEEECCHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]