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The map label for this gene is oxyR [H]

Identifier: 121999203

GI number: 121999203

Start: 2664580

End: 2665506

Strand: Reverse

Name: oxyR [H]

Synonym: Hhal_2425

Alternate gene names: 121999203

Gene position: 2665506-2664580 (Counterclockwise)

Preceding gene: 121999204

Following gene: 121999202

Centisome position: 99.52

GC content: 71.52

Gene sequence:

>927_bases
ATGAACCTGCGCGACCTCCGCTACCTGGTCGCCGTGGCCGAACACCGCCACTTCGGGCGGGCGGCCCGCGCCTGCTATGT
CAGCCAGCCGACGCTCTCCACGCAGCTGAAAAAGCTCGAGGAGTACCTCGAGGTCCAGCTCGTCGAGCGCAACCGCCGCC
GGGTGCTCCTCACGCCCCTGGGCGAGCGGTTGGCCGAACGCGCCCGCAGCATCCTCAGCGCCGTCGACGACATGGTCGAG
GTGGCACGGGCCCAGGCCGAGCCGATGACCGGGGATGTCCGCCTGGGTGTGATCCCCACCGCCGGCCCGTACCTGCTGCC
CCACGTCATCCCTGACCTGGCGCAGAGCTATCCGCGCCTGCGCCTGCATCTGCGCGAGGACCTGACCCAGCGCCTGCTCG
ATCAGCTCCGTGCCGGCAGCCTGGACGGCGCCATCCTGGCCTCGCCGATCGCCGGCGACGACCTGGTCTCCGAACCGCTC
TGCCATGAGCCGTTCTATCTGGCGGTGCCCCGCGGCCACGACCTGGATCGCCCGGAACCGGTCGACGCCAAGGATCTGCA
GCAGACCGAACTGATGCTCCTCGAGGAGGGGCACTGCCTGCGCGAACAGGCCCTGGAACTGTGCCGGCGCAACGACGTGG
GCGAGGCGGCGGCGTTCCGCGCCACGAGCCTCGAGACCCTGCGCCAGATGGTGGCCGCCGGGGTCGGCGTGACCCTGTTG
CCGGCTCTGGCGGCGGCCGCCTCGCGCCTGGGCCCGGATCACGCTGCCATTAGCCTGCGGCCCTTCGCCGAACCTGCCCC
CAGTCGCGACCTGGCCCTCTACTGGCGGGTGGGCACCGCCCGCGAACCCACCTTCCGCGAGCTGGTCGAACGGATGCGCA
GTGCCGCGGTGCTTCAAGACCCGACCCAGACCCTGCCGGCAGCCTGA

Upstream 100 bases:

>100_bases
CAGCTGCTCGCCTACCACGTGGCCGTGCTGCGCGGCACGGATGTCGACAAGCCGCGCAATCTGGCCAAGTCGGTCACCGT
CGAATGACAGGACCCGCCAC

Downstream 100 bases:

>100_bases
TATGCCCATCGATGCCCTGACCGCGGATCTCAACGATGCCCAGCGCGAGGCCGTGTGCCTGCCTCCGGGCCGCGCCCTGG
TGTTGGCCGGGGCCGGCAGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNLRDLRYLVAVAEHRHFGRAARACYVSQPTLSTQLKKLEEYLEVQLVERNRRRVLLTPLGERLAERARSILSAVDDMVE
VARAQAEPMTGDVRLGVIPTAGPYLLPHVIPDLAQSYPRLRLHLREDLTQRLLDQLRAGSLDGAILASPIAGDDLVSEPL
CHEPFYLAVPRGHDLDRPEPVDAKDLQQTELMLLEEGHCLREQALELCRRNDVGEAAAFRATSLETLRQMVAAGVGVTLL
PALAAAASRLGPDHAAISLRPFAEPAPSRDLALYWRVGTAREPTFRELVERMRSAAVLQDPTQTLPAA

Sequences:

>Translated_308_residues
MNLRDLRYLVAVAEHRHFGRAARACYVSQPTLSTQLKKLEEYLEVQLVERNRRRVLLTPLGERLAERARSILSAVDDMVE
VARAQAEPMTGDVRLGVIPTAGPYLLPHVIPDLAQSYPRLRLHLREDLTQRLLDQLRAGSLDGAILASPIAGDDLVSEPL
CHEPFYLAVPRGHDLDRPEPVDAKDLQQTELMLLEEGHCLREQALELCRRNDVGEAAAFRATSLETLRQMVAAGVGVTLL
PALAAAASRLGPDHAAISLRPFAEPAPSRDLALYWRVGTAREPTFRELVERMRSAAVLQDPTQTLPAA
>Mature_308_residues
MNLRDLRYLVAVAEHRHFGRAARACYVSQPTLSTQLKKLEEYLEVQLVERNRRRVLLTPLGERLAERARSILSAVDDMVE
VARAQAEPMTGDVRLGVIPTAGPYLLPHVIPDLAQSYPRLRLHLREDLTQRLLDQLRAGSLDGAILASPIAGDDLVSEPL
CHEPFYLAVPRGHDLDRPEPVDAKDLQQTELMLLEEGHCLREQALELCRRNDVGEAAAFRATSLETLRQMVAAGVGVTLL
PALAAAASRLGPDHAAISLRPFAEPAPSRDLALYWRVGTAREPTFRELVERMRSAAVLQDPTQTLPAA

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=294, Percent_Identity=46.9387755102041, Blast_Score=253, Evalue=8e-69,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=32.520325203252, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693105, Length=275, Percent_Identity=29.0909090909091, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI157672245, Length=265, Percent_Identity=33.5849056603774, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787530, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=28.135593220339, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367136, Length=280, Percent_Identity=27.1428571428571, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=29.1338582677165, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082132, Length=295, Percent_Identity=26.1016949152542, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787806, Length=287, Percent_Identity=25.4355400696864, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789506, Length=259, Percent_Identity=23.9382239382239, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=29.6551724137931, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87081904, Length=178, Percent_Identity=32.5842696629214, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=23.4567901234568, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=259, Percent_Identity=26.2548262548263, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI145693193, Length=174, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788626, Length=244, Percent_Identity=27.0491803278689, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34112; Mature: 34112

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDLRYLVAVAEHRHFGRAARACYVSQPTLSTQLKKLEEYLEVQLVERNRRRVLLTPL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECHH
GERLAERARSILSAVDDMVEVARAQAEPMTGDVRLGVIPTAGPYLLPHVIPDLAQSYPRL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
RLHLREDLTQRLLDQLRAGSLDGAILASPIAGDDLVSEPLCHEPFYLAVPRGHDLDRPEP
HHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCC
VDAKDLQQTELMLLEEGHCLREQALELCRRNDVGEAAAFRATSLETLRQMVAAGVGVTLL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
PALAAAASRLGPDHAAISLRPFAEPAPSRDLALYWRVGTAREPTFRELVERMRSAAVLQD
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
PTQTLPAA
CHHHCCCC
>Mature Secondary Structure
MNLRDLRYLVAVAEHRHFGRAARACYVSQPTLSTQLKKLEEYLEVQLVERNRRRVLLTPL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECHH
GERLAERARSILSAVDDMVEVARAQAEPMTGDVRLGVIPTAGPYLLPHVIPDLAQSYPRL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
RLHLREDLTQRLLDQLRAGSLDGAILASPIAGDDLVSEPLCHEPFYLAVPRGHDLDRPEP
HHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCC
VDAKDLQQTELMLLEEGHCLREQALELCRRNDVGEAAAFRATSLETLRQMVAAGVGVTLL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
PALAAAASRLGPDHAAISLRPFAEPAPSRDLALYWRVGTAREPTFRELVERMRSAAVLQD
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
PTQTLPAA
CHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]