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The map label for this gene is gor [H]

Identifier: 121999174

GI number: 121999174

Start: 2632321

End: 2633682

Strand: Reverse

Name: gor [H]

Synonym: Hhal_2396

Alternate gene names: 121999174

Gene position: 2633682-2632321 (Counterclockwise)

Preceding gene: 121999176

Following gene: 121999173

Centisome position: 98.33

GC content: 71.0

Gene sequence:

>1362_bases
ATGACGGACGAGTACGATCTGATCGTCATCGGTGGCGGTAGCGGCGGCATGGCGACGGCACGACGCGCCGCGGCCCACGG
TGCTCGCGTGGCCATGGTCGAGCGCGATCGCCTGGGGGGCACCTGCGTCAACGTCGGCTGCGTGCCCAAGAAGGTGATGT
GGTACGCCAGCGAGACGGCGGCGGCGCTGGAGCGCGCTGCCGACTTCGGCTTCAGCCTCGAGCAGGCTCCGGAGTTCGAC
TGGGGGGGGCTGTGCCGGGCCCGGGACGCCTACGTCGAGCGGCTCAACGGCATCTACGCCAGCAACGTCGAGCGCGCCGG
CATCGATCTCTACCGGGGCACCGGAGAGCTCCGTGACGCCCATACCGTGGCGGTGGATGGCCAGCCCCTGCGCGGCCGCT
ATATACTCCTCGCCCCGGGCGGGCGGCCGAGCCGGCCGGACATCCCCGGCGCCGATTACGGCATCGACTCCGACGGCTTC
TTCCAGCTCCACGAGCAGCCGCGTCGGGCCGTGGTGGTGGGGGCCGGTTACATCGCCGTGGAACTGGCCGGCGTGCTCCA
CCACCTGGGCACCGAGACCACCCTGACCGTGCGCCGGGACGGTCCCCTGCGTGGCTTCGATCCGCTGCTACGGGAGTCGC
TGGCCGAGAGCCTGGAAGTGGACGGGTTCGACCTGCGCACCCACTTCGTCCCCGCCGCCTGCGAGCGCCAGGCCGATGGG
CGGCTCACGCTGCTGGCCGAAGACGGTCAACGGATCGAGGACGTGGATACCGTCATCTGGGCCATCGGCCGGGATGCCGC
CACCGCGGACCTGGGTCTTGAGCGGGCCGGCATCACCCCGCGGGCGGATGGCACCATTCCGGTGGACGACTACCAGCGCA
CCGAGGTCGACTCGGTGCTCGCCGTGGGGGACGTCACCGGCAACGACTTCCCGCTGACCCCCGTGGCCATCGCCGCCGGA
CGCCGGCTGGCCGACCGGCTCTTCGCCGGCCAGAGCGACAGCCGGCTGGCGTACCGGGACATCCCCTCCGTGGTCTTCAC
CCACCCGCCGCTGGGCACCGTGGGCATGACCGAGCCGGAGGCCGAGGCCGCCTACGGCGCCGATCAGGTCACCTGCTATC
AGACGCGGTTCTTCCCCATGAACTACGCCCTGGCCCCGCAGGCGGTGAAGCGGCGCACGGCCATGAAGCTGGTGACCGTG
GGTGCCGAGGAGCGGGTGGTCGGCGTGCACATCTTCGGCGAGGCCGCCGACGAGATGCTCCAGGGTTTCGCCGTGGCGGT
GCGCATGGGGGCCACCAAGGCCGATTTCGACAACACAGTGGCCATCCACCCCACCAGCGCCGAAGAACTGGTCACCCTGT
GA

Upstream 100 bases:

>100_bases
TGGAGCGGACGCGTTACACTCTAGCACGCGTGCGGCGAACGATCCCTGTACCCGAGCCGGGGCGATCCGTTCGCCCGAAG
CTGCTTGTCGAGGAGGGTCC

Downstream 100 bases:

>100_bases
GCGCAAGGGAGCCGACATGATCCGCGAATTCGGAGGCATTCGCCCGCAGTTGGGGCCCGGCGCCTGGGTCGACGCCACGG
CCCTGGTCATCGGCGATGTG

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTDEYDLIVIGGGSGGMATARRAAAHGARVAMVERDRLGGTCVNVGCVPKKVMWYASETAAALERAADFGFSLEQAPEFD
WGGLCRARDAYVERLNGIYASNVERAGIDLYRGTGELRDAHTVAVDGQPLRGRYILLAPGGRPSRPDIPGADYGIDSDGF
FQLHEQPRRAVVVGAGYIAVELAGVLHHLGTETTLTVRRDGPLRGFDPLLRESLAESLEVDGFDLRTHFVPAACERQADG
RLTLLAEDGQRIEDVDTVIWAIGRDAATADLGLERAGITPRADGTIPVDDYQRTEVDSVLAVGDVTGNDFPLTPVAIAAG
RRLADRLFAGQSDSRLAYRDIPSVVFTHPPLGTVGMTEPEAEAAYGADQVTCYQTRFFPMNYALAPQAVKRRTAMKLVTV
GAEERVVGVHIFGEAADEMLQGFAVAVRMGATKADFDNTVAIHPTSAEELVTL

Sequences:

>Translated_453_residues
MTDEYDLIVIGGGSGGMATARRAAAHGARVAMVERDRLGGTCVNVGCVPKKVMWYASETAAALERAADFGFSLEQAPEFD
WGGLCRARDAYVERLNGIYASNVERAGIDLYRGTGELRDAHTVAVDGQPLRGRYILLAPGGRPSRPDIPGADYGIDSDGF
FQLHEQPRRAVVVGAGYIAVELAGVLHHLGTETTLTVRRDGPLRGFDPLLRESLAESLEVDGFDLRTHFVPAACERQADG
RLTLLAEDGQRIEDVDTVIWAIGRDAATADLGLERAGITPRADGTIPVDDYQRTEVDSVLAVGDVTGNDFPLTPVAIAAG
RRLADRLFAGQSDSRLAYRDIPSVVFTHPPLGTVGMTEPEAEAAYGADQVTCYQTRFFPMNYALAPQAVKRRTAMKLVTV
GAEERVVGVHIFGEAADEMLQGFAVAVRMGATKADFDNTVAIHPTSAEELVTL
>Mature_452_residues
TDEYDLIVIGGGSGGMATARRAAAHGARVAMVERDRLGGTCVNVGCVPKKVMWYASETAAALERAADFGFSLEQAPEFDW
GGLCRARDAYVERLNGIYASNVERAGIDLYRGTGELRDAHTVAVDGQPLRGRYILLAPGGRPSRPDIPGADYGIDSDGFF
QLHEQPRRAVVVGAGYIAVELAGVLHHLGTETTLTVRRDGPLRGFDPLLRESLAESLEVDGFDLRTHFVPAACERQADGR
LTLLAEDGQRIEDVDTVIWAIGRDAATADLGLERAGITPRADGTIPVDDYQRTEVDSVLAVGDVTGNDFPLTPVAIAAGR
RLADRLFAGQSDSRLAYRDIPSVVFTHPPLGTVGMTEPEAEAAYGADQVTCYQTRFFPMNYALAPQAVKRRTAMKLVTVG
AEERVVGVHIFGEAADEMLQGFAVAVRMGATKADFDNTVAIHPTSAEELVTL

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=50.3225806451613, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=34.4298245614035, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=34.4298245614035, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=34.4298245614035, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=34.4298245614035, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=37.5796178343949, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=34.4298245614035, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=35.1162790697674, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=32.7906976744186, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=28.0777537796976, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1789915, Length=454, Percent_Identity=51.9823788546256, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=28.0434782608696, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87082354, Length=470, Percent_Identity=29.3617021276596, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.9565217391304, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=52.8761061946903, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=52.8761061946903, Blast_Score=420, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=34.1101694915254, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=34.5833333333333, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=28.9079229122056, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=45.0643776824034, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=26.8498942917548, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=24.9471458773784, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=40, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=40, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=40, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=37.8435517970402, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI21358499, Length=474, Percent_Identity=28.4810126582279, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48646; Mature: 48515

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEYDLIVIGGGSGGMATARRAAAHGARVAMVERDRLGGTCVNVGCVPKKVMWYASETA
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHEEECHHHH
AALERAADFGFSLEQAPEFDWGGLCRARDAYVERLNGIYASNVERAGIDLYRGTGELRDA
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCCCC
HTVAVDGQPLRGRYILLAPGGRPSRPDIPGADYGIDSDGFFQLHEQPRRAVVVGAGYIAV
EEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
ELAGVLHHLGTETTLTVRRDGPLRGFDPLLRESLAESLEVDGFDLRTHFVPAACERQADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCC
RLTLLAEDGQRIEDVDTVIWAIGRDAATADLGLERAGITPRADGTIPVDDYQRTEVDSVL
CEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHHEE
AVGDVTGNDFPLTPVAIAAGRRLADRLFAGQSDSRLAYRDIPSVVFTHPPLGTVGMTEPE
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHCCCCEEEECCCCCCCCCCCCC
AEAAYGADQVTCYQTRFFPMNYALAPQAVKRRTAMKLVTVGAEERVVGVHIFGEAADEML
CHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHEEEEEECCCCEEEEEEEECHHHHHHH
QGFAVAVRMGATKADFDNTVAIHPTSAEELVTL
HHHHEEHEECCCCCCCCCEEEECCCCHHHHHCC
>Mature Secondary Structure 
TDEYDLIVIGGGSGGMATARRAAAHGARVAMVERDRLGGTCVNVGCVPKKVMWYASETA
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHEEECHHHH
AALERAADFGFSLEQAPEFDWGGLCRARDAYVERLNGIYASNVERAGIDLYRGTGELRDA
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCCCC
HTVAVDGQPLRGRYILLAPGGRPSRPDIPGADYGIDSDGFFQLHEQPRRAVVVGAGYIAV
EEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
ELAGVLHHLGTETTLTVRRDGPLRGFDPLLRESLAESLEVDGFDLRTHFVPAACERQADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCC
RLTLLAEDGQRIEDVDTVIWAIGRDAATADLGLERAGITPRADGTIPVDDYQRTEVDSVL
CEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHHEE
AVGDVTGNDFPLTPVAIAAGRRLADRLFAGQSDSRLAYRDIPSVVFTHPPLGTVGMTEPE
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHCCCCEEEECCCCCCCCCCCCC
AEAAYGADQVTCYQTRFFPMNYALAPQAVKRRTAMKLVTVGAEERVVGVHIFGEAADEML
CHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHEEEEEECCCCEEEEEEEECHHHHHHH
QGFAVAVRMGATKADFDNTVAIHPTSAEELVTL
HHHHEEHEECCCCCCCCCEEEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]