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The map label for this gene is gcp

Identifier: 121999105

GI number: 121999105

Start: 2553537

End: 2554544

Strand: Reverse

Name: gcp

Synonym: Hhal_2327

Alternate gene names: 121999105

Gene position: 2554544-2553537 (Counterclockwise)

Preceding gene: 121999106

Following gene: 121999101

Centisome position: 95.37

GC content: 73.02

Gene sequence:

>1008_bases
GTGCGTGTACTAGGCATCGAGAGTTCCTGTGACGAGACCGCGGCCGCCGTCTACTGTGGTCGTGATGGCCTGTTGGCCCA
CGCGGTGCACAGTCAGGTGGCCGATCACGCCGCTTACGGCGGCGTGGTGCCGGAGCTGGCCTCACGGGATCACGTGCGCA
AGCTGCCCGGTCTGGTCGGTGGGGTGTTGCGGGATGCCGGCCTGACGCCGGCAGATCTCGACGGCGTCGCCTGGACCCGC
GGCCCAGGGCTCCCCGGGGCCTTGATGGTCGGGGCCGGGTTCGCGCGCACCTTCGCCTGGGCGCGGGGGCTGCCGGCGGT
CGGGGTGCACCACATGGAGGGGCACCTGCTGGCGCCCCTGCTCGAGCCCGACCCGCCGGCCATGCCCCTGGTGGCCCTGC
TGGTCTCCGGCGGGCATACGATGCTGGTGCAGGTGGCCGACTTCGGCCGCTACCGGGTCCTGGGGGAGTCGGTGGATGAC
GCCGCCGGCGAGGCCTTCGACAAGACGGCTCGGCTGCTGGGGCTGCCGTACCCGGGGGGGCCGGCCATCGCCCGCCTCGC
CGTCGAGGGAACACCGGGGGCGGTGCGCCTGCCGCGGCCGATGACCGACCGGCCGGGGCTGGACTTCAGCTTCAGCGGCC
TGAAGACGGCGGTCCTCCACGCCGTCGAGGCGGCGGGGAACGATCAGCAGGCCCGGGCGGACATCGCCCACGGATTCCAG
GAGGCGGTGGTGGATACCCTGGTGATCAAGTGCCGGCGTGCCATCGAGCAGACGGGCGCGGGCCGGCTCGTGGTCTCCGG
CGGGGTGGGCGCCAACGCCCGGTTGCGCGAACGCCTGGATGAGGTGGGGCGGGCGAGCGGCTTCACCGCCCACTACCCGC
GCCTGGAGCTGTGTACCGACAACGCTGCGATGATCGCCTACGCCGGCCTGCGTCGGCTGGAGGCGGGCTACCGCGACGAT
CTCGACTTCAGCGTACGCCCCCGCTGGCCGTTGGCCGAGCTCAGCTAG

Upstream 100 bases:

>100_bases
GGGCTGGAGCGGCCGACCCCGATCCGGGACGGACGCAGTGGGGCCTACCTGAGACGATGACGCGCCGCTTTCTGTATACG
CCGCAATCCGGGGGTGCCCA

Downstream 100 bases:

>100_bases
TGGCCTTGCTGCGGCCGCGGCCACCCTTGGCCGCCCCGCCGCGGCGCCCCTTGCGCGCCGGCGCCTTGGCGATCAGGTCC
TGGCACTCCTCATGGGTGAG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRVLGIESSCDETAAAVYCGRDGLLAHAVHSQVADHAAYGGVVPELASRDHVRKLPGLVGGVLRDAGLTPADLDGVAWTR
GPGLPGALMVGAGFARTFAWARGLPAVGVHHMEGHLLAPLLEPDPPAMPLVALLVSGGHTMLVQVADFGRYRVLGESVDD
AAGEAFDKTARLLGLPYPGGPAIARLAVEGTPGAVRLPRPMTDRPGLDFSFSGLKTAVLHAVEAAGNDQQARADIAHGFQ
EAVVDTLVIKCRRAIEQTGAGRLVVSGGVGANARLRERLDEVGRASGFTAHYPRLELCTDNAAMIAYAGLRRLEAGYRDD
LDFSVRPRWPLAELS

Sequences:

>Translated_335_residues
MRVLGIESSCDETAAAVYCGRDGLLAHAVHSQVADHAAYGGVVPELASRDHVRKLPGLVGGVLRDAGLTPADLDGVAWTR
GPGLPGALMVGAGFARTFAWARGLPAVGVHHMEGHLLAPLLEPDPPAMPLVALLVSGGHTMLVQVADFGRYRVLGESVDD
AAGEAFDKTARLLGLPYPGGPAIARLAVEGTPGAVRLPRPMTDRPGLDFSFSGLKTAVLHAVEAAGNDQQARADIAHGFQ
EAVVDTLVIKCRRAIEQTGAGRLVVSGGVGANARLRERLDEVGRASGFTAHYPRLELCTDNAAMIAYAGLRRLEAGYRDD
LDFSVRPRWPLAELS
>Mature_335_residues
MRVLGIESSCDETAAAVYCGRDGLLAHAVHSQVADHAAYGGVVPELASRDHVRKLPGLVGGVLRDAGLTPADLDGVAWTR
GPGLPGALMVGAGFARTFAWARGLPAVGVHHMEGHLLAPLLEPDPPAMPLVALLVSGGHTMLVQVADFGRYRVLGESVDD
AAGEAFDKTARLLGLPYPGGPAIARLAVEGTPGAVRLPRPMTDRPGLDFSFSGLKTAVLHAVEAAGNDQQARADIAHGFQ
EAVVDTLVIKCRRAIEQTGAGRLVVSGGVGANARLRERLDEVGRASGFTAHYPRLELCTDNAAMIAYAGLRRLEAGYRDD
LDFSVRPRWPLAELS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=356, Percent_Identity=34.8314606741573, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI8923380, Length=341, Percent_Identity=34.0175953079179, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=61.9760479041916, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17557464, Length=328, Percent_Identity=34.1463414634146, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71995670, Length=327, Percent_Identity=32.7217125382263, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320099, Length=368, Percent_Identity=32.0652173913043, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322891, Length=298, Percent_Identity=29.8657718120805, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129063, Length=351, Percent_Identity=33.6182336182336, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21357207, Length=332, Percent_Identity=30.7228915662651, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_HALHL (A1WZH8)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003892.1
- ProteinModelPortal:   A1WZH8
- SMR:   A1WZH8
- STRING:   A1WZH8
- MEROPS:   M22.001
- GeneID:   4709284
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2327
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   A1WZH8
- ProtClustDB:   PRK09604
- BioCyc:   HHAL349124:HHAL_2327-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35205; Mature: 35205

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS01016 GLYCOPROTEASE; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLGIESSCDETAAAVYCGRDGLLAHAVHSQVADHAAYGGVVPELASRDHVRKLPGLVG
CEEECCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHH
GVLRDAGLTPADLDGVAWTRGPGLPGALMVGAGFARTFAWARGLPAVGVHHMEGHLLAPL
HHHHHCCCCCCCCCCCEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCCEECCCCCEECCC
LEPDPPAMPLVALLVSGGHTMLVQVADFGRYRVLGESVDDAAGEAFDKTARLLGLPYPGG
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
PAIARLAVEGTPGAVRLPRPMTDRPGLDFSFSGLKTAVLHAVEAAGNDQQARADIAHGFQ
HHEEEEEEECCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EAVVDTLVIKCRRAIEQTGAGRLVVSGGVGANARLRERLDEVGRASGFTAHYPRLELCTD
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCEEEEECC
NAAMIAYAGLRRLEAGYRDDLDFSVRPRWPLAELS
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVLGIESSCDETAAAVYCGRDGLLAHAVHSQVADHAAYGGVVPELASRDHVRKLPGLVG
CEEECCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHH
GVLRDAGLTPADLDGVAWTRGPGLPGALMVGAGFARTFAWARGLPAVGVHHMEGHLLAPL
HHHHHCCCCCCCCCCCEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCCEECCCCCEECCC
LEPDPPAMPLVALLVSGGHTMLVQVADFGRYRVLGESVDDAAGEAFDKTARLLGLPYPGG
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
PAIARLAVEGTPGAVRLPRPMTDRPGLDFSFSGLKTAVLHAVEAAGNDQQARADIAHGFQ
HHEEEEEEECCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EAVVDTLVIKCRRAIEQTGAGRLVVSGGVGANARLRERLDEVGRASGFTAHYPRLELCTD
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCEEEEECC
NAAMIAYAGLRRLEAGYRDDLDFSVRPRWPLAELS
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA