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The map label for this gene is fmt

Identifier: 121999100

GI number: 121999100

Start: 2547835

End: 2548767

Strand: Reverse

Name: fmt

Synonym: Hhal_2322

Alternate gene names: 121999100

Gene position: 2548767-2547835 (Counterclockwise)

Preceding gene: 121999101

Following gene: 121999099

Centisome position: 95.16

GC content: 73.53

Gene sequence:

>933_bases
ATGGCGGCACGGATCGTCTTTGCCGGAACCCCGGATTTTGCGGTGCCCGGCCTCGATGCCCTGGTCGAGGCCGGGGTGAG
GCCCGTGGCGGTCTTCACCCAGCCCGACCGGCCCGCCGGGCGAGGGCGGAGGCTGACCCCGCCGCCGGTCAAGCGGGCCG
CCGAGCGCCACGGGCTGGGCGTTCACCAGCCCGAGCGCCTGGGGGCCGAAGAGGCGGAGCAGATCCGCGCGCTGGCGCCC
GATCTGATGGTGGTGGTGGCCTACGGCCAGATCCTGCGGCGCAATGTGCTGGACGTACCGCGCTTTGGCTGCGTGAATGT
CCACGCCTCGCTGCTGCCGCGCTGGCGGGGCGCGGCGCCGATCCAGCGCGCCCTGCTGGCCGGGGACGAGCAGACCGGTG
TAACCCTCATGCAGATGGACGAGGGACTGGATACCGGGCCCATGCTTGCCCGCAAGGCGACCCCGATCAGTGCCGACGAA
ACCGCCGGGTCGCTCCACGACCGCCTGGCGCGCATCGGCGCCGACCTGCTGGTCGCCCACCTGCCCGAGATTCTGGCCGG
GGCCATCACCCCGGAGCCTCAGCCGGACGACGGCGTGACCTACGCCGCCAAGCTGACCAACGACGAGAGCTGGCTCGATC
CCACCGAGCCCGCGGAGCAACTGGAGCGGCGCGTGCGCGCCCTGGCCCCGGTCCCCGGAGCGCGGCTCCAGCTGGGCGAG
ACGCCGGTGCGGGTACTGGCGGCACGGGCCTGTGCGGGGCGGCCCGAGGATCGGGCCGGAACCGTGGCGGCGGTGGGCAG
TGGCGGCATCGAGGTCGCTACCGGCGAGGGGCGTCTTGAGATCACCCGGCTGAAGCCCGCCGGTGGGCGGGAACAGACGG
CTGCCGATTACCTCAACGGGCGCCGCCTGGTGCCGGGAGAGCCGGTTCAGTGA

Upstream 100 bases:

>100_bases
ATCTGGACGGTCGACTGTTCATCGACTACCTCTCCGAGCTCAAGCGCAAGCGGGTGCGCAAGCGCATGGAGAAACGCGAG
CGGCTCAGCGCGGCGGGCTG

Downstream 100 bases:

>100_bases
GTACCCCCCCGCGGGTCGCCGCGGTGCACGTCCTTGAACGGGTGCTGGAGCGCGGCGAGACCCTGGATGAGGCCCTGGAG
GCCCAGTTTTCCCGGGTATC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAARIVFAGTPDFAVPGLDALVEAGVRPVAVFTQPDRPAGRGRRLTPPPVKRAAERHGLGVHQPERLGAEEAEQIRALAP
DLMVVVAYGQILRRNVLDVPRFGCVNVHASLLPRWRGAAPIQRALLAGDEQTGVTLMQMDEGLDTGPMLARKATPISADE
TAGSLHDRLARIGADLLVAHLPEILAGAITPEPQPDDGVTYAAKLTNDESWLDPTEPAEQLERRVRALAPVPGARLQLGE
TPVRVLAARACAGRPEDRAGTVAAVGSGGIEVATGEGRLEITRLKPAGGREQTAADYLNGRRLVPGEPVQ

Sequences:

>Translated_310_residues
MAARIVFAGTPDFAVPGLDALVEAGVRPVAVFTQPDRPAGRGRRLTPPPVKRAAERHGLGVHQPERLGAEEAEQIRALAP
DLMVVVAYGQILRRNVLDVPRFGCVNVHASLLPRWRGAAPIQRALLAGDEQTGVTLMQMDEGLDTGPMLARKATPISADE
TAGSLHDRLARIGADLLVAHLPEILAGAITPEPQPDDGVTYAAKLTNDESWLDPTEPAEQLERRVRALAPVPGARLQLGE
TPVRVLAARACAGRPEDRAGTVAAVGSGGIEVATGEGRLEITRLKPAGGREQTAADYLNGRRLVPGEPVQ
>Mature_309_residues
AARIVFAGTPDFAVPGLDALVEAGVRPVAVFTQPDRPAGRGRRLTPPPVKRAAERHGLGVHQPERLGAEEAEQIRALAPD
LMVVVAYGQILRRNVLDVPRFGCVNVHASLLPRWRGAAPIQRALLAGDEQTGVTLMQMDEGLDTGPMLARKATPISADET
AGSLHDRLARIGADLLVAHLPEILAGAITPEPQPDDGVTYAAKLTNDESWLDPTEPAEQLERRVRALAPVPGARLQLGET
PVRVLAARACAGRPEDRAGTVAAVGSGGIEVATGEGRLEITRLKPAGGREQTAADYLNGRRLVPGEPVQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=251, Percent_Identity=33.4661354581673, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI238814322, Length=243, Percent_Identity=28.8065843621399, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI21614513, Length=252, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789683, Length=307, Percent_Identity=51.4657980456026, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788589, Length=281, Percent_Identity=32.3843416370107, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI133930964, Length=261, Percent_Identity=27.2030651340996, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550868, Length=304, Percent_Identity=29.9342105263158, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=32, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585660, Length=319, Percent_Identity=26.0188087774295, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_HALHL (A1WZH3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003887.1
- ProteinModelPortal:   A1WZH3
- SMR:   A1WZH3
- STRING:   A1WZH3
- GeneID:   4709354
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2322
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   A1WZH3
- BioCyc:   HHAL349124:HHAL_2322-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32830; Mature: 32699

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARIVFAGTPDFAVPGLDALVEAGVRPVAVFTQPDRPAGRGRRLTPPPVKRAAERHGLG
CCEEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VHQPERLGAEEAEQIRALAPDLMVVVAYGQILRRNVLDVPRFGCVNVHASLLPRWRGAAP
CCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCH
IQRALLAGDEQTGVTLMQMDEGLDTGPMLARKATPISADETAGSLHDRLARIGADLLVAH
HHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LPEILAGAITPEPQPDDGVTYAAKLTNDESWLDPTEPAEQLERRVRALAPVPGARLQLGE
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECC
TPVRVLAARACAGRPEDRAGTVAAVGSGGIEVATGEGRLEITRLKPAGGREQTAADYLNG
CHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCCEEEEEEECCCCCCHHHHHHHHCC
RRLVPGEPVQ
CCCCCCCCCC
>Mature Secondary Structure 
AARIVFAGTPDFAVPGLDALVEAGVRPVAVFTQPDRPAGRGRRLTPPPVKRAAERHGLG
CEEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VHQPERLGAEEAEQIRALAPDLMVVVAYGQILRRNVLDVPRFGCVNVHASLLPRWRGAAP
CCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCH
IQRALLAGDEQTGVTLMQMDEGLDTGPMLARKATPISADETAGSLHDRLARIGADLLVAH
HHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LPEILAGAITPEPQPDDGVTYAAKLTNDESWLDPTEPAEQLERRVRALAPVPGARLQLGE
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECC
TPVRVLAARACAGRPEDRAGTVAAVGSGGIEVATGEGRLEITRLKPAGGREQTAADYLNG
CHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCCEEEEEEECCCCCCHHHHHHHHCC
RRLVPGEPVQ
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA