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The map label for this gene is algC [H]

Identifier: 121999075

GI number: 121999075

Start: 2524966

End: 2526360

Strand: Reverse

Name: algC [H]

Synonym: Hhal_2297

Alternate gene names: 121999075

Gene position: 2526360-2524966 (Counterclockwise)

Preceding gene: 121999076

Following gene: 121999074

Centisome position: 94.32

GC content: 69.25

Gene sequence:

>1395_bases
GTGAGCGCAGCGCAAGTACCCGCATCGATCTTTCGTGCCTACGACGTCCGTGGCGTGGTGGGCGAGACCCTGAATGCCGA
CATCGTCCGCTGGGTGGGCCGTGCGGTGGGCAGCGAGGCGCGCGAGCGCGGCGTCCGCCGCCTGGTGGTCGGCCGTGACG
GCCGTCACTCCAGTGCCGAGCTGGCCGCGGCGGTGGCTGCCGGCATGAACGACGCCGGATGCGATGTCGTTGACATCGGC
CAGGCCCCCACGCCGGTGATGTACTTCGCCACCCACGAGCTGGAGACCGGCTCCGGGGTGATGATCACTGGCAGCCACAA
CCCGCCGGAGTACAACGGACTGAAGATCATGGTCGCCGGCGACACCCTCTCTGGCGAGGCCATCACGGCCCTCTATCGGC
GCATCCAGGACGGCTGCCTGTCCGCAGGGGAGGGGGGCGTGGAATCGCGTACGGACCTGGTGGAGCGCTACTTGGCGCGG
ATTACCGGCGATATCCGCCCGGCGCGTTCCCTGCGGGTGGTCCTCGATGCCGGTAACGGCGTCGCCGGCGCGGTGGCGCC
GCAGCTCTTCGAGGCCCTGGGCTGTGAGGTGGAGGCCCTGTTCTGCGACGTGGATGGCGACTTCCCCAACCACCATCCGG
ACCCGGCCGAACCGCACAACCTGGAGACGCTCATCGCACGGGTCCGCGAGAGCGGGGCCGACCTGGGCCTGGCCTTTGAC
GGCGACGGCGATCGCCTCGGGGTCGTGGACTCGGCAGGCAAAATCATCTGGCCCGACCGGCAGCTGATGCTCTACGCCCG
CGATGTGCTCAGCCGCCGTCCCGGCGAGCCGGTGGTCTTCGACGTCAAGTGCAGTATGCACCTCAAGCAGGTCATCGAGG
CGGCCGGTGGGCGGCCGCAGATGTCGCGCACCGGGCACTCGCTGATCAAAGCCACACTGCGCGAAACCGGTGCCCCGCTG
GCCGGCGAGATGAGCGGCCACACCTTCTTCGCCGAGCGCTGGTACGGCTTCGACGACGGTCTTTACACCGGCGCGCGGCT
GGTGGAGATCGTCGCCGCCGACGGCCGGCCCAGCGCCGAGATCTTCGCCGAACTGCCCGAGGGTGTCTCCACGCCGGAGC
TTAAGGTGCACATCCAGGAGGGTGAACAGGTCGAGCTCATGGACGCACTGGTGACGGAAGGGCAGCGGCGGTTCACCGAC
GCCACCATCCACACCATCGACGGCATCCGTGTGGAGTGGTCTGATGGCTGGGGGTTGATCCGCGCCTCCAACACCACGCC
GGTGCTGGTGGTGCGTTTCGAGGCCAACGACGACGCCGGCCTGGCCCGCATTCGGGAGGCCTTCGAGGCTCTGCTCGCGG
CCGTGCGGCCGGGGCTGGCGATACCCGGCGGATGA

Upstream 100 bases:

>100_bases
GGCGTTCTCGGCCACCACCGAGCGCGGCGAGGGCGGATTCGGCCACAGCGGCACGCTATGACGGGGGAGTCCCCGCACCG
AGAATGACAAGGAGGAGCCC

Downstream 100 bases:

>100_bases
TGCCCACCGCACCGGCGCCTTGTCAGGAGCCGTTCGGCCCTGGAAACTCCCAGCGCGAAACCAGATAACGATACCCAGCC
TCCAAACCCGAATCTCAGAA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSAAQVPASIFRAYDVRGVVGETLNADIVRWVGRAVGSEARERGVRRLVVGRDGRHSSAELAAAVAAGMNDAGCDVVDIG
QAPTPVMYFATHELETGSGVMITGSHNPPEYNGLKIMVAGDTLSGEAITALYRRIQDGCLSAGEGGVESRTDLVERYLAR
ITGDIRPARSLRVVLDAGNGVAGAVAPQLFEALGCEVEALFCDVDGDFPNHHPDPAEPHNLETLIARVRESGADLGLAFD
GDGDRLGVVDSAGKIIWPDRQLMLYARDVLSRRPGEPVVFDVKCSMHLKQVIEAAGGRPQMSRTGHSLIKATLRETGAPL
AGEMSGHTFFAERWYGFDDGLYTGARLVEIVAADGRPSAEIFAELPEGVSTPELKVHIQEGEQVELMDALVTEGQRRFTD
ATIHTIDGIRVEWSDGWGLIRASNTTPVLVVRFEANDDAGLARIREAFEALLAAVRPGLAIPGG

Sequences:

>Translated_464_residues
MSAAQVPASIFRAYDVRGVVGETLNADIVRWVGRAVGSEARERGVRRLVVGRDGRHSSAELAAAVAAGMNDAGCDVVDIG
QAPTPVMYFATHELETGSGVMITGSHNPPEYNGLKIMVAGDTLSGEAITALYRRIQDGCLSAGEGGVESRTDLVERYLAR
ITGDIRPARSLRVVLDAGNGVAGAVAPQLFEALGCEVEALFCDVDGDFPNHHPDPAEPHNLETLIARVRESGADLGLAFD
GDGDRLGVVDSAGKIIWPDRQLMLYARDVLSRRPGEPVVFDVKCSMHLKQVIEAAGGRPQMSRTGHSLIKATLRETGAPL
AGEMSGHTFFAERWYGFDDGLYTGARLVEIVAADGRPSAEIFAELPEGVSTPELKVHIQEGEQVELMDALVTEGQRRFTD
ATIHTIDGIRVEWSDGWGLIRASNTTPVLVVRFEANDDAGLARIREAFEALLAAVRPGLAIPGG
>Mature_463_residues
SAAQVPASIFRAYDVRGVVGETLNADIVRWVGRAVGSEARERGVRRLVVGRDGRHSSAELAAAVAAGMNDAGCDVVDIGQ
APTPVMYFATHELETGSGVMITGSHNPPEYNGLKIMVAGDTLSGEAITALYRRIQDGCLSAGEGGVESRTDLVERYLARI
TGDIRPARSLRVVLDAGNGVAGAVAPQLFEALGCEVEALFCDVDGDFPNHHPDPAEPHNLETLIARVRESGADLGLAFDG
DGDRLGVVDSAGKIIWPDRQLMLYARDVLSRRPGEPVVFDVKCSMHLKQVIEAAGGRPQMSRTGHSLIKATLRETGAPLA
GEMSGHTFFAERWYGFDDGLYTGARLVEIVAADGRPSAEIFAELPEGVSTPELKVHIQEGEQVELMDALVTEGQRRFTDA
TIHTIDGIRVEWSDGWGLIRASNTTPVLVVRFEANDDAGLARIREAFEALLAAVRPGLAIPGG

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=449, Percent_Identity=32.293986636971, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1789566, Length=453, Percent_Identity=28.9183222958057, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 49582; Mature: 49450

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAQVPASIFRAYDVRGVVGETLNADIVRWVGRAVGSEARERGVRRLVVGRDGRHSSAE
CCCCHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCHHHHHCCCEEEEECCCCCCCHHH
LAAAVAAGMNDAGCDVVDIGQAPTPVMYFATHELETGSGVMITGSHNPPEYNGLKIMVAG
HHHHHHCCCCCCCCCEEECCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEC
DTLSGEAITALYRRIQDGCLSAGEGGVESRTDLVERYLARITGDIRPARSLRVVLDAGNG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
VAGAVAPQLFEALGCEVEALFCDVDGDFPNHHPDPAEPHNLETLIARVRESGADLGLAFD
CCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GDGDRLGVVDSAGKIIWPDRQLMLYARDVLSRRPGEPVVFDVKCSMHLKQVIEAAGGRPQ
CCCCEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCC
MSRTGHSLIKATLRETGAPLAGEMSGHTFFAERWYGFDDGLYTGARLVEIVAADGRPSAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHCCCCCCCHHHHHEEEEEEECCCCCHHH
IFAELPEGVSTPELKVHIQEGEQVELMDALVTEGQRRFTDATIHTIDGIRVEWSDGWGLI
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHCCCEEEEECCEEEEECCCCEEE
RASNTTPVLVVRFEANDDAGLARIREAFEALLAAVRPGLAIPGG
EECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAAQVPASIFRAYDVRGVVGETLNADIVRWVGRAVGSEARERGVRRLVVGRDGRHSSAE
CCCHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCHHHHHCCCEEEEECCCCCCCHHH
LAAAVAAGMNDAGCDVVDIGQAPTPVMYFATHELETGSGVMITGSHNPPEYNGLKIMVAG
HHHHHHCCCCCCCCCEEECCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEC
DTLSGEAITALYRRIQDGCLSAGEGGVESRTDLVERYLARITGDIRPARSLRVVLDAGNG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
VAGAVAPQLFEALGCEVEALFCDVDGDFPNHHPDPAEPHNLETLIARVRESGADLGLAFD
CCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GDGDRLGVVDSAGKIIWPDRQLMLYARDVLSRRPGEPVVFDVKCSMHLKQVIEAAGGRPQ
CCCCEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCC
MSRTGHSLIKATLRETGAPLAGEMSGHTFFAERWYGFDDGLYTGARLVEIVAADGRPSAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHCCCCCCCHHHHHEEEEEEECCCCCHHH
IFAELPEGVSTPELKVHIQEGEQVELMDALVTEGQRRFTDATIHTIDGIRVEWSDGWGLI
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHCCCEEEEECCEEEEECCCCEEE
RASNTTPVLVVRFEANDDAGLARIREAFEALLAAVRPGLAIPGG
EECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]