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The map label for this gene is hldE

Identifier: 121999040

GI number: 121999040

Start: 2482832

End: 2484265

Strand: Reverse

Name: hldE

Synonym: Hhal_2261

Alternate gene names: 121999040

Gene position: 2484265-2482832 (Counterclockwise)

Preceding gene: 121999042

Following gene: 121999037

Centisome position: 92.75

GC content: 72.87

Gene sequence:

>1434_bases
ATGACTCCCCCGCTGCCCGGTTTCCGCGATGTCCGGGTCGTCGTCGCCGGCGATCTGATGCTCGACCGTTACTGGCATGG
GGCGACCCAGCGCATCTCACCGGAAGCCCCGGTCCCGGTGGTGCGGGTCGATGGCGCCGAGGAGCGTCCGGGCGGTGCTG
CGAATGTCGCGCTCAATGTGGCCGCCCTCGGTGGCGAGGCGCAGGTGGTGGGCCCGACCGGCAGCGACGAGGCAGCCGAC
CGGCTGGCGGAGCTGCTCGAGGCTGCTGGTGTTGGCCAGCGATTCCACCGCATCGCCGGCGCTGACACCATCACCAAGCT
GCGGGTGATCAGTCGACACCAGCAGCTGATCCGCCTCGACTTCGAACGCGGCTTCCCGGGGTTCGACCACGCCGCCATGC
TGGCCCTGCTCGAGCCCGCCCTGGCCGATGCCGCGGTGCTGGTCCTCTCCGACTACGCCAAGGGGGCGCTCCCCGATCCG
GCCGGGTTGATCGAGGCCGCCCGCCGAGCCGGGCGGCCGGTGCTGGTCGACCCCAAGGGGGCGGACTACCGTCGCTACCG
CGGTGCCAGCCTGCTGACGCCCAACCTGGCGGAGTTCGAGGCAGTGGTCGGGCCGTGCGCCGATGGCGATGAGATCGCCA
AGCGGGCGAGGCAACTGGCGGCCGATCTGGAGCTGGAGGCGTTGCTGGTGACCCGGGGCGAGGCTGGGATGACCCTCGCC
CCGCGGGAGGGGGTGGCGGTGCATCTGCCGACCCGGGCCCGAGAGGTCTTCGATGTCACGGGTGCCGGCGATACGGTGAT
CGCCACGCTCGCCGCTGCCCTGGGCGCCGGGGTGGATCTGGCCGATGCGTCGGCTCTGGCCAACGTGGCCGCCGGAGTCG
TGGTGGGCAAGCTGGGGACCGCCACGGTCACCCCGGCAGAGCTGGAGGCGGCGCTGGGCGGTGGCCCGGCCCCGGCAGCG
GGTTCCGGGGTGGTGGACGAGCCGGGCCTGTTGGCAGCGGTGCGCCAGGCCCGTGCGGCGGGCGAACGGATCGTCATGAC
CAACGGCTGCTTCGACCTGCTCCACGCCGGTCATGTCGACTACCTGCAGCGGGCCCGCCGGCGCGGCGAGCGGCTGGTGG
TGGCGGTCAACGACGATGCCTCGGTGGCGCGGCTTAAGGGGGCGGAACGGCCGGTCACGCCCCTGGCGCAGCGCATGGCG
GTGCTTGCCGCCCTGGACACGGTGGATTGGGTGGTGCCGTTCAGCGAGGACACCCCGGCGCGGCTGATCGAGGCGGTGTT
GCCGGACCGGCTGGTCAAGGGTGGGGACTATCAGCCCGAGCAGATCGCCGGCCACGACGTCGTGGTCGCCGCCGGCGGCT
CGGTGGAGGTCCTGCCCCTGCTCGCCGGCGCATCGACCACGGACCTGATCGCGCGCATTCGCAGCCGCGGCTAG

Upstream 100 bases:

>100_bases
ACACGCGCTGCGCCTGACACCTCGGCGCCCCGGCTTCTGTCGGCTGGGCCGGCGCGGCTATAATCCCCGACCTGTACACC
GACAGGATGCCCGCTCACCC

Downstream 100 bases:

>100_bases
CTGCCTGCCGCGGCGGACCGACCGGATGCGCCGCGGTCGGCCAGCGCCGCGTCCAGCCGCGCGGCCACATCGGCCACGGT
GATCCAGTCCATGGCCTCGG

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTPPLPGFRDVRVVVAGDLMLDRYWHGATQRISPEAPVPVVRVDGAEERPGGAANVALNVAALGGEAQVVGPTGSDEAAD
RLAELLEAAGVGQRFHRIAGADTITKLRVISRHQQLIRLDFERGFPGFDHAAMLALLEPALADAAVLVLSDYAKGALPDP
AGLIEAARRAGRPVLVDPKGADYRRYRGASLLTPNLAEFEAVVGPCADGDEIAKRARQLAADLELEALLVTRGEAGMTLA
PREGVAVHLPTRAREVFDVTGAGDTVIATLAAALGAGVDLADASALANVAAGVVVGKLGTATVTPAELEAALGGGPAPAA
GSGVVDEPGLLAAVRQARAAGERIVMTNGCFDLLHAGHVDYLQRARRRGERLVVAVNDDASVARLKGAERPVTPLAQRMA
VLAALDTVDWVVPFSEDTPARLIEAVLPDRLVKGGDYQPEQIAGHDVVVAAGGSVEVLPLLAGASTTDLIARIRSRG

Sequences:

>Translated_477_residues
MTPPLPGFRDVRVVVAGDLMLDRYWHGATQRISPEAPVPVVRVDGAEERPGGAANVALNVAALGGEAQVVGPTGSDEAAD
RLAELLEAAGVGQRFHRIAGADTITKLRVISRHQQLIRLDFERGFPGFDHAAMLALLEPALADAAVLVLSDYAKGALPDP
AGLIEAARRAGRPVLVDPKGADYRRYRGASLLTPNLAEFEAVVGPCADGDEIAKRARQLAADLELEALLVTRGEAGMTLA
PREGVAVHLPTRAREVFDVTGAGDTVIATLAAALGAGVDLADASALANVAAGVVVGKLGTATVTPAELEAALGGGPAPAA
GSGVVDEPGLLAAVRQARAAGERIVMTNGCFDLLHAGHVDYLQRARRRGERLVVAVNDDASVARLKGAERPVTPLAQRMA
VLAALDTVDWVVPFSEDTPARLIEAVLPDRLVKGGDYQPEQIAGHDVVVAAGGSVEVLPLLAGASTTDLIARIRSRG
>Mature_476_residues
TPPLPGFRDVRVVVAGDLMLDRYWHGATQRISPEAPVPVVRVDGAEERPGGAANVALNVAALGGEAQVVGPTGSDEAADR
LAELLEAAGVGQRFHRIAGADTITKLRVISRHQQLIRLDFERGFPGFDHAAMLALLEPALADAAVLVLSDYAKGALPDPA
GLIEAARRAGRPVLVDPKGADYRRYRGASLLTPNLAEFEAVVGPCADGDEIAKRARQLAADLELEALLVTRGEAGMTLAP
REGVAVHLPTRAREVFDVTGAGDTVIATLAAALGAGVDLADASALANVAAGVVVGKLGTATVTPAELEAALGGGPAPAAG
SGVVDEPGLLAAVRQARAAGERIVMTNGCFDLLHAGHVDYLQRARRRGERLVVAVNDDASVARLKGAERPVTPLAQRMAV
LAALDTVDWVVPFSEDTPARLIEAVLPDRLVKGGDYQPEQIAGHDVVVAAGGSVEVLPLLAGASTTDLIARIRSRG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=475, Percent_Identity=58.9473684210526, Blast_Score=529, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_HALHL (A1WZB3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003827.1
- ProteinModelPortal:   A1WZB3
- SMR:   A1WZB3
- STRING:   A1WZB3
- GeneID:   4709137
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2261
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- PhylomeDB:   A1WZB3
- ProtClustDB:   PRK11316
- BioCyc:   HHAL349124:HHAL_2261-MONOMER
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 49379; Mature: 49248

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPLPGFRDVRVVVAGDLMLDRYWHGATQRISPEAPVPVVRVDGAEERPGGAANVALNV
CCCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGGEAQVVGPTGSDEAADRLAELLEAAGVGQRFHRIAGADTITKLRVISRHQQLIRLD
EEECCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEE
FERGFPGFDHAAMLALLEPALADAAVLVLSDYAKGALPDPAGLIEAARRAGRPVLVDPKG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCC
ADYRRYRGASLLTPNLAEFEAVVGPCADGDEIAKRARQLAADLELEALLVTRGEAGMTLA
CCHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEC
PREGVAVHLPTRAREVFDVTGAGDTVIATLAAALGAGVDLADASALANVAAGVVVGKLGT
CCCCCEEECCCCCCHHEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCC
ATVTPAELEAALGGGPAPAAGSGVVDEPGLLAAVRQARAAGERIVMTNGCFDLLHAGHVD
CCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHH
YLQRARRRGERLVVAVNDDASVARLKGAERPVTPLAQRMAVLAALDTVDWVVPFSEDTPA
HHHHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCHH
RLIEAVLPDRLVKGGDYQPEQIAGHDVVVAAGGSVEVLPLLAGASTTDLIARIRSRG
HHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TPPLPGFRDVRVVVAGDLMLDRYWHGATQRISPEAPVPVVRVDGAEERPGGAANVALNV
CCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGGEAQVVGPTGSDEAADRLAELLEAAGVGQRFHRIAGADTITKLRVISRHQQLIRLD
EEECCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEE
FERGFPGFDHAAMLALLEPALADAAVLVLSDYAKGALPDPAGLIEAARRAGRPVLVDPKG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCC
ADYRRYRGASLLTPNLAEFEAVVGPCADGDEIAKRARQLAADLELEALLVTRGEAGMTLA
CCHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEC
PREGVAVHLPTRAREVFDVTGAGDTVIATLAAALGAGVDLADASALANVAAGVVVGKLGT
CCCCCEEECCCCCCHHEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCC
ATVTPAELEAALGGGPAPAAGSGVVDEPGLLAAVRQARAAGERIVMTNGCFDLLHAGHVD
CCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHH
YLQRARRRGERLVVAVNDDASVARLKGAERPVTPLAQRMAVLAALDTVDWVVPFSEDTPA
HHHHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCHH
RLIEAVLPDRLVKGGDYQPEQIAGHDVVVAAGGSVEVLPLLAGASTTDLIARIRSRG
HHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA