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The map label for this gene is dapA

Identifier: 121998977

GI number: 121998977

Start: 2412288

End: 2413190

Strand: Reverse

Name: dapA

Synonym: Hhal_2198

Alternate gene names: 121998977

Gene position: 2413190-2412288 (Counterclockwise)

Preceding gene: 121998980

Following gene: 121998976

Centisome position: 90.1

GC content: 68.11

Gene sequence:

>903_bases
ATGACGGAGGTGGTGATGTTCCGCGGCAGCATGGTGGCGATGGTCACCCCGATGAAGGCGCAGGATGGAATTCGGGACGC
CGTGGATGAGAAGGCGCTCAAGCAGCTGGTCGAGTATCACGTCGAGCAGGGCAGTGACGCCATCGTTGCCGTGGGGACCA
CCGGCGAATCGGCCACTCTCGACTACGAAGAGCACCGGGATGTGATCCGCGCCACGGTCGAGGCCGCTGCGGGCCGAATC
CCGGTGATCGGCGGCACCGGTGCCAACTCGACCTGGGAGGCCATCGAGCTGACCCGCAGCGCCATGGAGGCCGGCTGTGA
TGCGGCGCTGCTGGTGGTGCCCTACTACAACAAGCCCACCCAGGAAGGGCTGGTTCAGCACTTCAGCGCCATCGCCGAGG
CGGTGCCCATCCCTCAGATCCTCTACAACGTGCCGGGCCGCACTGGGTGCGACATGCTCCCCGAGACCGTCGAGCGCCTT
GCCGACCTGCCCAACGTGGTCGGCCTCAAGGAGGCCCAGGGCACCGTGGAGCGGGCCGAGGAGGTGATCCGCCGCTGCGG
TGATCGGCTGGATGTCTTCGCCGGCGACGACTTCAACGCCCTGGGCATGATGCGGGTCGGTGGCAAGGGGGTGATCTCGG
TCAGCGCCAATGTCGTCCCGCGGCAGATGCACGACCTCTGTGCGGCCGCCCTGGCCGGCGACATGCAGACCGCCGAGGCC
ATCAACGAGCGCCTGACGCCCCTGCACCAGGCGATGTTCTGCGAGCCTAACCCGGTACCGGTGAAGTGGGCGGTGGAGGA
GCTCGGCATGGCCGGTTCCGGTATGCGCCTGCCCATGACCCGCCTGACCGAGGCCGGGCAGGCCCGGGTGCGCCAGGCGA
TGCAAGACGCCGGTCTGCTGTGA

Upstream 100 bases:

>100_bases
GAACCCGGTCACGGTGCGTCGGGGTCCGGTGGGGATCCTTGCTTGGCGCCGCGCAGCCCGCTTAGTACCATGACCCCCTT
GCCGATCAGACTCGTGACCG

Downstream 100 bases:

>100_bases
GGGGCCGGGTCGCCAATGGCGCCCGCTGGGTCCTGGTGGCGGTGCTCGCCACCGGGCTGCTGGGCGCCTGTGCCACGGAC
CCGCTGACCCGCGACGAGGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEVVMFRGSMVAMVTPMKAQDGIRDAVDEKALKQLVEYHVEQGSDAIVAVGTTGESATLDYEEHRDVIRATVEAAAGRI
PVIGGTGANSTWEAIELTRSAMEAGCDAALLVVPYYNKPTQEGLVQHFSAIAEAVPIPQILYNVPGRTGCDMLPETVERL
ADLPNVVGLKEAQGTVERAEEVIRRCGDRLDVFAGDDFNALGMMRVGGKGVISVSANVVPRQMHDLCAAALAGDMQTAEA
INERLTPLHQAMFCEPNPVPVKWAVEELGMAGSGMRLPMTRLTEAGQARVRQAMQDAGLL

Sequences:

>Translated_300_residues
MTEVVMFRGSMVAMVTPMKAQDGIRDAVDEKALKQLVEYHVEQGSDAIVAVGTTGESATLDYEEHRDVIRATVEAAAGRI
PVIGGTGANSTWEAIELTRSAMEAGCDAALLVVPYYNKPTQEGLVQHFSAIAEAVPIPQILYNVPGRTGCDMLPETVERL
ADLPNVVGLKEAQGTVERAEEVIRRCGDRLDVFAGDDFNALGMMRVGGKGVISVSANVVPRQMHDLCAAALAGDMQTAEA
INERLTPLHQAMFCEPNPVPVKWAVEELGMAGSGMRLPMTRLTEAGQARVRQAMQDAGLL
>Mature_299_residues
TEVVMFRGSMVAMVTPMKAQDGIRDAVDEKALKQLVEYHVEQGSDAIVAVGTTGESATLDYEEHRDVIRATVEAAAGRIP
VIGGTGANSTWEAIELTRSAMEAGCDAALLVVPYYNKPTQEGLVQHFSAIAEAVPIPQILYNVPGRTGCDMLPETVERLA
DLPNVVGLKEAQGTVERAEEVIRRCGDRLDVFAGDDFNALGMMRVGGKGVISVSANVVPRQMHDLCAAALAGDMQTAEAI
NERLTPLHQAMFCEPNPVPVKWAVEELGMAGSGMRLPMTRLTEAGQARVRQAMQDAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=26.2068965517241, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13540533, Length=238, Percent_Identity=27.7310924369748, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788823, Length=296, Percent_Identity=53.7162162162162, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI87082415, Length=284, Percent_Identity=30.9859154929577, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786463, Length=254, Percent_Identity=29.5275590551181, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=29.957805907173, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_HALHL (A1WZ50)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003764.1
- ProteinModelPortal:   A1WZ50
- SMR:   A1WZ50
- STRING:   A1WZ50
- GeneID:   4709552
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2198
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   A1WZ50
- ProtClustDB:   PRK03170
- BioCyc:   HHAL349124:HHAL_2198-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32160; Mature: 32029

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 170-170 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVVMFRGSMVAMVTPMKAQDGIRDAVDEKALKQLVEYHVEQGSDAIVAVGTTGESATL
CCCEEEECCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
DYEEHRDVIRATVEAAAGRIPVIGGTGANSTWEAIELTRSAMEAGCDAALLVVPYYNKPT
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
QEGLVQHFSAIAEAVPIPQILYNVPGRTGCDMLPETVERLADLPNVVGLKEAQGTVERAE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVIRRCGDRLDVFAGDDFNALGMMRVGGKGVISVSANVVPRQMHDLCAAALAGDMQTAEA
HHHHHCCCCEEEEECCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHH
INERLTPLHQAMFCEPNPVPVKWAVEELGMAGSGMRLPMTRLTEAGQARVRQAMQDAGLL
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEVVMFRGSMVAMVTPMKAQDGIRDAVDEKALKQLVEYHVEQGSDAIVAVGTTGESATL
CCEEEECCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
DYEEHRDVIRATVEAAAGRIPVIGGTGANSTWEAIELTRSAMEAGCDAALLVVPYYNKPT
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
QEGLVQHFSAIAEAVPIPQILYNVPGRTGCDMLPETVERLADLPNVVGLKEAQGTVERAE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVIRRCGDRLDVFAGDDFNALGMMRVGGKGVISVSANVVPRQMHDLCAAALAGDMQTAEA
HHHHHCCCCEEEEECCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHH
INERLTPLHQAMFCEPNPVPVKWAVEELGMAGSGMRLPMTRLTEAGQARVRQAMQDAGLL
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA