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The map label for this gene is 121998969

Identifier: 121998969

GI number: 121998969

Start: 2401991

End: 2402437

Strand: Reverse

Name: 121998969

Synonym: Hhal_2190

Alternate gene names: NA

Gene position: 2402437-2401991 (Counterclockwise)

Preceding gene: 121998973

Following gene: 121998966

Centisome position: 89.69

GC content: 69.35

Gene sequence:

>447_bases
ATGAGTTCGATTGTGGTGGGTATGGACGGCTCCACAGGAGCGCAGCGTGCCCTCAACTGGGCGGTCAACGAGGCGGCGCT
GCGCCGCTGCCCGGTGCGGGCGATCTACGTCATCGACCGGCGTTACCTGGACTCGGATCTCGGTGTGCTGGTGGCCCCTG
CTGCCTCGGAGCTGGAAGCGGAGGCGCGGGCGATCCTCGACCGGGCGGTGGGTGCCATCGGCGAGGTGCCCGAAGGGGTC
GACCTGCGCAAAGAGGTGGTCCATGCCGAGCGGCACGGCATTGTCGGTACGCTGCTCGATCAGGCCGGGCAGGATGCAGA
GCTGTTCGTTGTCGGCAGCCGCGGTCACGGCGGCTTTGCCGGCCTGTTGCTCGGCTCGGTGAGCCACCAGGTGCTGCAGC
ACGCGTCCTGCCCCGTGGTGGTCGTCCCCCACGGTCGCGAGGGCTAG

Upstream 100 bases:

>100_bases
TTCATTTCGCCTTCCTTTCCCCGTAGTCTGTGCCGATGGTCACTGGACTATAATTCACTCGGTCCGTCGAAAAACAGCCT
GCACGACCCAAGGGGGGCTT

Downstream 100 bases:

>100_bases
CCAGGCCGTCACCCTAGCGCGTCGGGAAGCGCCGCCAGGCGCCGCGACCGTAGATCTCCGGGAAGGTGCCGAGGACCTCG
GACTGTTCCTGGCGGATGCC

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MSSIVVGMDGSTGAQRALNWAVNEAALRRCPVRAIYVIDRRYLDSDLGVLVAPAASELEAEARAILDRAVGAIGEVPEGV
DLRKEVVHAERHGIVGTLLDQAGQDAELFVVGSRGHGGFAGLLLGSVSHQVLQHASCPVVVVPHGREG

Sequences:

>Translated_148_residues
MSSIVVGMDGSTGAQRALNWAVNEAALRRCPVRAIYVIDRRYLDSDLGVLVAPAASELEAEARAILDRAVGAIGEVPEGV
DLRKEVVHAERHGIVGTLLDQAGQDAELFVVGSRGHGGFAGLLLGSVSHQVLQHASCPVVVVPHGREG
>Mature_147_residues
SSIVVGMDGSTGAQRALNWAVNEAALRRCPVRAIYVIDRRYLDSDLGVLVAPAASELEAEARAILDRAVGAIGEVPEGVD
LRKEVVHAERHGIVGTLLDQAGQDAELFVVGSRGHGGFAGLLLGSVSHQVLQHASCPVVVVPHGREG

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 15507; Mature: 15376

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIVVGMDGSTGAQRALNWAVNEAALRRCPVRAIYVIDRRYLDSDLGVLVAPAASELEA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEEECCHHHHHH
EARAILDRAVGAIGEVPEGVDLRKEVVHAERHGIVGTLLDQAGQDAELFVVGSRGHGGFA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCHH
GLLLGSVSHQVLQHASCPVVVVPHGREG
HHHHHHHHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure 
SSIVVGMDGSTGAQRALNWAVNEAALRRCPVRAIYVIDRRYLDSDLGVLVAPAASELEA
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEEECCHHHHHH
EARAILDRAVGAIGEVPEGVDLRKEVVHAERHGIVGTLLDQAGQDAELFVVGSRGHGGFA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCHH
GLLLGSVSHQVLQHASCPVVVVPHGREG
HHHHHHHHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]