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The map label for this gene is pgi1 [H]

Identifier: 121998956

GI number: 121998956

Start: 2387835

End: 2389451

Strand: Reverse

Name: pgi1 [H]

Synonym: Hhal_2177

Alternate gene names: 121998956

Gene position: 2389451-2387835 (Counterclockwise)

Preceding gene: 121998957

Following gene: 121998955

Centisome position: 89.21

GC content: 70.5

Gene sequence:

>1617_bases
ATGACGACTGCGCTGACGCACTCCCCGGTCTGGCAGGAACTGCTTGGCCACGATGACACCGAACACGCAGGTGCGCTCCT
GGGGGCCGATCCGGGGCGCGTCGAGCGCTACTGCCTGCACCACGAAGACCTGCGCGTCGATCTCTCCCGGCACCCGGTGA
CCGATTCCACCTGGGAGCGGCTGCTGCGCCTAGCCGAGGAGCGCGGCGTCCCCGGGCGCATCGAGGCGTTGTTCTCGGGG
GCGTCCGTCAACGAGTCCGAGGGGCGGCCTGCGCTGCATACGGCGCTGCGCAGCAGGCCCGATGCCTCCATCCATGTGGA
TGGCGAAGACGTGATCCCGGCCGTCTACGAGGAGCTGCAGCGCATGGCTGCCTTCGTCGAGGCCCTGCGCAGTGGCGATG
TGCGCGGCTACGACGGTCGGCCCCTGCGCCACGTGGTGAACATCGGCATCGGTGGCTCGGAGGCCGGCGTCACCATGGCC
CATCAGGCCCTGGCCGACGGTGATGAACCCCTGCGGCTCCATACCGTATCCGGGGTGGACGGGCGCGAGCTGGCCGCTGT
GTGGGGGCGGATCGACCCGGCCGAAACCCTCTTCTGCGTGGCCTCCAAGTCCTTCTCCACCCTGGAGACCCTCACCAATG
CCCGGACCGCGTGGGCGTGGCTGGAGGCGGAGGCCGGGCGGCCGGTGCCAGAGCAGTTCGTGGGCATCTCGGCGAACGAG
TCGGCCATGGCCGATTTCGGGATTCCCGCCGAGCGGCGGTTCCGGATCTGGGAGTGGGTCGGTGGTCGCTACTCCCTGCC
GTCAACCATGGGGCTGCCGCTGGCGGCGGTGATCGGTATGGAGCGCTTCAACGAGCTGCGCCGCGGCATGCGTGCCATGG
ATGAGCACTTCCGGAGCGCGCCGGCGGCGCAGAATATCCCTTTGCTGCTCGGGCTCCTCGGGGTCTGGCAGATCAGCCTC
CGCGGCGCCACCGGGCACGTCGTGTTGCCGTATCACCCGGGGCTGCGCCGGCTTCCGGCCTACCTACAGCAGCTGGACAT
GGAAAGCCTGGGCAAGTCGGTTACCCGCGATGGGCAGCCGGTGGACTACCCCACCGGGACCAGCTGCTGGGGCGAGGTGG
GGATCAACGGCCAGCACTCGTTCTTTCAGTGGCTGCATCAGGGCACCGGTCGGGTCATCGCCGAGTTCCTCGTGCCGGTG
GAGGAGGGCGGCCTGCCCGAGCGGCACGCCGGGCTGAACCTGGCGAGCGCCCTGGGCCAGGTCCAGGCGCTGTGCCAGGG
GCAGGCGCCGCAGGGGAGCGGGCCGGAGGCCGAGCACCACCGCTACGAGGGCGGCCGACCGGTGACGCTCATCCTTTTCC
GGCGGCTCGACGCCTATACACTCGGGCGCCTGCTGGCCCTGCACGAGCATCGCGTGTTCGTCCAGGCGAGCCTTTGGGGG
ATCAATCCCTTCGATCAGTGGGGCGTCGAGCTGGGCAAGCGGGTGGCCAAGGGGTTGGCCCCGGTTGCCCGCGGCGAGGC
GCCACCGCCCGCCGAGGCGGATGCCGCGACCCGTCAGGCCCTGCGTTGGGCGGGGTGTTGGGGCGCTGGCGAGTCGTCCG
ACGGGACGGGTGTTTGA

Upstream 100 bases:

>100_bases
TTCGTCGCCCCCTCTGAGCGCCGGTCGTCCCGAGGCTTGAAACCGGCGGGGGCTGCCTCGATGACCGAGGGTGTGTTGGG
CGACAGAGGATGGACTGTAG

Downstream 100 bases:

>100_bases
CATCTCTTTTGAGCGCTTCTAAATTAGAGCCTAAAGATTAGAAGCGTTCAAAGGTGTAAGCATGAAACCCGCCGCTGCCC
TCCGCAACCGGATCGACCGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 1; Phosphoglucose isomerase 1; PGI 1; Phosphohexose isomerase 1; PHI 1 [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MTTALTHSPVWQELLGHDDTEHAGALLGADPGRVERYCLHHEDLRVDLSRHPVTDSTWERLLRLAEERGVPGRIEALFSG
ASVNESEGRPALHTALRSRPDASIHVDGEDVIPAVYEELQRMAAFVEALRSGDVRGYDGRPLRHVVNIGIGGSEAGVTMA
HQALADGDEPLRLHTVSGVDGRELAAVWGRIDPAETLFCVASKSFSTLETLTNARTAWAWLEAEAGRPVPEQFVGISANE
SAMADFGIPAERRFRIWEWVGGRYSLPSTMGLPLAAVIGMERFNELRRGMRAMDEHFRSAPAAQNIPLLLGLLGVWQISL
RGATGHVVLPYHPGLRRLPAYLQQLDMESLGKSVTRDGQPVDYPTGTSCWGEVGINGQHSFFQWLHQGTGRVIAEFLVPV
EEGGLPERHAGLNLASALGQVQALCQGQAPQGSGPEAEHHRYEGGRPVTLILFRRLDAYTLGRLLALHEHRVFVQASLWG
INPFDQWGVELGKRVAKGLAPVARGEAPPPAEADAATRQALRWAGCWGAGESSDGTGV

Sequences:

>Translated_538_residues
MTTALTHSPVWQELLGHDDTEHAGALLGADPGRVERYCLHHEDLRVDLSRHPVTDSTWERLLRLAEERGVPGRIEALFSG
ASVNESEGRPALHTALRSRPDASIHVDGEDVIPAVYEELQRMAAFVEALRSGDVRGYDGRPLRHVVNIGIGGSEAGVTMA
HQALADGDEPLRLHTVSGVDGRELAAVWGRIDPAETLFCVASKSFSTLETLTNARTAWAWLEAEAGRPVPEQFVGISANE
SAMADFGIPAERRFRIWEWVGGRYSLPSTMGLPLAAVIGMERFNELRRGMRAMDEHFRSAPAAQNIPLLLGLLGVWQISL
RGATGHVVLPYHPGLRRLPAYLQQLDMESLGKSVTRDGQPVDYPTGTSCWGEVGINGQHSFFQWLHQGTGRVIAEFLVPV
EEGGLPERHAGLNLASALGQVQALCQGQAPQGSGPEAEHHRYEGGRPVTLILFRRLDAYTLGRLLALHEHRVFVQASLWG
INPFDQWGVELGKRVAKGLAPVARGEAPPPAEADAATRQALRWAGCWGAGESSDGTGV
>Mature_537_residues
TTALTHSPVWQELLGHDDTEHAGALLGADPGRVERYCLHHEDLRVDLSRHPVTDSTWERLLRLAEERGVPGRIEALFSGA
SVNESEGRPALHTALRSRPDASIHVDGEDVIPAVYEELQRMAAFVEALRSGDVRGYDGRPLRHVVNIGIGGSEAGVTMAH
QALADGDEPLRLHTVSGVDGRELAAVWGRIDPAETLFCVASKSFSTLETLTNARTAWAWLEAEAGRPVPEQFVGISANES
AMADFGIPAERRFRIWEWVGGRYSLPSTMGLPLAAVIGMERFNELRRGMRAMDEHFRSAPAAQNIPLLLGLLGVWQISLR
GATGHVVLPYHPGLRRLPAYLQQLDMESLGKSVTRDGQPVDYPTGTSCWGEVGINGQHSFFQWLHQGTGRVIAEFLVPVE
EGGLPERHAGLNLASALGQVQALCQGQAPQGSGPEAEHHRYEGGRPVTLILFRRLDAYTLGRLLALHEHRVFVQASLWGI
NPFDQWGVELGKRVAKGLAPVARGEAPPPAEADAATRQALRWAGCWGAGESSDGTGV

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=547, Percent_Identity=40.9506398537477, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI296080693, Length=542, Percent_Identity=38.7453874538745, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1790457, Length=543, Percent_Identity=39.7790055248619, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71996708, Length=527, Percent_Identity=40.7969639468691, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71996703, Length=527, Percent_Identity=40.7969639468691, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319673, Length=465, Percent_Identity=41.7204301075269, Blast_Score=369, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651916, Length=527, Percent_Identity=40.0379506641366, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651914, Length=527, Percent_Identity=40.0379506641366, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17737445, Length=527, Percent_Identity=40.0379506641366, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58508; Mature: 58377

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTALTHSPVWQELLGHDDTEHAGALLGADPGRVERYCLHHEDLRVDLSRHPVTDSTWER
CCCCCCCCHHHHHHHCCCCCHHCCEEECCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHH
LLRLAEERGVPGRIEALFSGASVNESEGRPALHTALRSRPDASIHVDGEDVIPAVYEELQ
HHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
RMAAFVEALRSGDVRGYDGRPLRHVVNIGIGGSEAGVTMAHQALADGDEPLRLHTVSGVD
HHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCC
GRELAAVWGRIDPAETLFCVASKSFSTLETLTNARTAWAWLEAEAGRPVPEQFVGISANE
CHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHCCHHHHEEEECCCCCCCHHHHCCCCCCC
SAMADFGIPAERRFRIWEWVGGRYSLPSTMGLPLAAVIGMERFNELRRGMRAMDEHFRSA
CHHHHCCCCHHHHEEHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAAQNIPLLLGLLGVWQISLRGATGHVVLPYHPGLRRLPAYLQQLDMESLGKSVTRDGQP
CCCCCCHHHHHHHHHHEEEEECCCCCEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCC
VDYPTGTSCWGEVGINGQHSFFQWLHQGTGRVIAEFLVPVEEGGLPERHAGLNLASALGQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHH
VQALCQGQAPQGSGPEAEHHRYEGGRPVTLILFRRLDAYTLGRLLALHEHRVFVQASLWG
HHHHHCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEECC
INPFDQWGVELGKRVAKGLAPVARGEAPPPAEADAATRQALRWAGCWGAGESSDGTGV
CCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTALTHSPVWQELLGHDDTEHAGALLGADPGRVERYCLHHEDLRVDLSRHPVTDSTWER
CCCCCCCHHHHHHHCCCCCHHCCEEECCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHH
LLRLAEERGVPGRIEALFSGASVNESEGRPALHTALRSRPDASIHVDGEDVIPAVYEELQ
HHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
RMAAFVEALRSGDVRGYDGRPLRHVVNIGIGGSEAGVTMAHQALADGDEPLRLHTVSGVD
HHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCC
GRELAAVWGRIDPAETLFCVASKSFSTLETLTNARTAWAWLEAEAGRPVPEQFVGISANE
CHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHCCHHHHEEEECCCCCCCHHHHCCCCCCC
SAMADFGIPAERRFRIWEWVGGRYSLPSTMGLPLAAVIGMERFNELRRGMRAMDEHFRSA
CHHHHCCCCHHHHEEHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAAQNIPLLLGLLGVWQISLRGATGHVVLPYHPGLRRLPAYLQQLDMESLGKSVTRDGQP
CCCCCCHHHHHHHHHHEEEEECCCCCEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCC
VDYPTGTSCWGEVGINGQHSFFQWLHQGTGRVIAEFLVPVEEGGLPERHAGLNLASALGQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHH
VQALCQGQAPQGSGPEAEHHRYEGGRPVTLILFRRLDAYTLGRLLALHEHRVFVQASLWG
HHHHHCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEECC
INPFDQWGVELGKRVAKGLAPVARGEAPPPAEADAATRQALRWAGCWGAGESSDGTGV
CCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]