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The map label for this gene is murC

Identifier: 121998869

GI number: 121998869

Start: 2293751

End: 2295211

Strand: Reverse

Name: murC

Synonym: Hhal_2090

Alternate gene names: 121998869

Gene position: 2295211-2293751 (Counterclockwise)

Preceding gene: 121998870

Following gene: 121998868

Centisome position: 85.69

GC content: 71.32

Gene sequence:

>1461_bases
ATGGCTGATGGCGTTCCCGCCCGCGAGCCGCGTTTCACCGCGCCGATGGACGGCCGCAGTACCTTCGGCCGGGTGCGGCG
TATCCACTTCGTGGGCATCGGCGGGGCCGGCATGGGCGGCATCGCGGAGGTGCTGCACAACCTCGGCTTCACCATTACCG
GCTCCGACGTGAGGTCGGGGGCGGTGGTCGAACGCCTGGTCGGCCTCGGCGTGACCGTCCAGATTGGCCACGACCCGGTC
CATGTCCAGGGGATGGATGCGGTCGTGGTCTCCACCGCGGTCACCGAAGACAACCCCGAGGTGCAGGCGGCGCGTCAGCA
GCGCATCCCGGTGGTGCCGCGGGCCGAGATGCTCGCCGAGCTGATGCGTTTTCGACACGGCGTAGCGGTCGCCGGGACCC
ACGGCAAGACGACGACTACCTCGCTGCTGGCCAGTTGCCTGGCCGAGGGCGAGCTCGATCCGACCTTCGTGATCGGTGGG
CGGCTGATCAGCGCCGGGGCCCACGCCCGTCTGGGCGCCGGACCCTATCTGGTGGCCGAGGCCGACGAGAGCGACGCCTC
GTTCCTCCACCTCAAGCCGATGATGGCGGCGGTCACCAACGTCGATGCCGACCACCTGGGCACCTACGGGGGCGATTTCG
AGGCTCTGCGCCGGACCTTCATCGAGTTCCTGCACCACCTGCCGTTTTACGGCTTGGCGGTGCTGTGCATCGACGACCCG
GAGGTGCGCCGGCTGCGCGGCGAGATCGGCCGTCCGGTGCTGACCTACGGCTTCTCCGAGGACGCCGATGTGCGCGTCAG
TGGCATGGAGGCGGACGGTCACCGGACGCGGTTCCGGATTGAGGAGGGCGACGGGGCGGCCTTCGCCGTCGAGCTGAGCC
TGCCGGGGCGGCACAACGTGCTCAATGCCGCCGCCGCCATCGCCTTGGCCCGCGAGCTGGGCGTCGACGTGGCCGCGATC
CAGCGGGCATTGTCCAGCTTCCAGGGTATCGGCCGGCGGTTTCAGGTCTACCCGGACATCCCCCTGGCCGAGGGTGCGGC
GGCGCTGGTCGACGACTACGCCCACCACCCCCGTGAGCTGGAGGCGACCCTGCAGGCGGCCCGGGCGGCCTGGCCGGAGC
GGCGTCTGGTGGTGGTCTTCCAGCCCCACCGTTATTCGCGGACCCGGGAGCTGTTCGATGACTTTGCGCGGGTGCTCAGT
GGCACCGATGCGCTGGTGCTGACTGAGGTCTACGCCGCCGGCGAGGCGCGCCTGCCCGGCGCCGACGGCCGGGCGCTGGC
CTCGGCGGTGCGTGATCGCGGCGGCGCGCAGCCGATCTTCGCCGAGAGCCTGGACGAGGTGCCGGGTTTGCTGGCCGGGC
TGCTGCGTGACGACGACGTGGTGCTGACCCTGGGGGCCGGCAGTATTGGCGGGCTTCCGGCGCAGCTGGGCGGCGGTCTG
ACCGCCGGGGGTGGGGCATGA

Upstream 100 bases:

>100_bases
GGCGACCGGCGTCGTCTGGCGGAGATGGGTGAGGCGGCGCGTGGCGTGGCCCGTCCGGACGCCACGGACCGCGTGGCGAC
GATCTGTGAGGAGGTGGCCC

Downstream 100 bases:

>100_bases
GTGCAGCCGCGGAACGGCGCCGGATCCGGCCCGGCGAGTGGCGCGAGCAGGAGCCCATGGCCGGGTACACCACCTGGCGG
GTGGGTGGCCCGGCGCGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MADGVPAREPRFTAPMDGRSTFGRVRRIHFVGIGGAGMGGIAEVLHNLGFTITGSDVRSGAVVERLVGLGVTVQIGHDPV
HVQGMDAVVVSTAVTEDNPEVQAARQQRIPVVPRAEMLAELMRFRHGVAVAGTHGKTTTTSLLASCLAEGELDPTFVIGG
RLISAGAHARLGAGPYLVAEADESDASFLHLKPMMAAVTNVDADHLGTYGGDFEALRRTFIEFLHHLPFYGLAVLCIDDP
EVRRLRGEIGRPVLTYGFSEDADVRVSGMEADGHRTRFRIEEGDGAAFAVELSLPGRHNVLNAAAAIALARELGVDVAAI
QRALSSFQGIGRRFQVYPDIPLAEGAAALVDDYAHHPRELEATLQAARAAWPERRLVVVFQPHRYSRTRELFDDFARVLS
GTDALVLTEVYAAGEARLPGADGRALASAVRDRGGAQPIFAESLDEVPGLLAGLLRDDDVVLTLGAGSIGGLPAQLGGGL
TAGGGA

Sequences:

>Translated_486_residues
MADGVPAREPRFTAPMDGRSTFGRVRRIHFVGIGGAGMGGIAEVLHNLGFTITGSDVRSGAVVERLVGLGVTVQIGHDPV
HVQGMDAVVVSTAVTEDNPEVQAARQQRIPVVPRAEMLAELMRFRHGVAVAGTHGKTTTTSLLASCLAEGELDPTFVIGG
RLISAGAHARLGAGPYLVAEADESDASFLHLKPMMAAVTNVDADHLGTYGGDFEALRRTFIEFLHHLPFYGLAVLCIDDP
EVRRLRGEIGRPVLTYGFSEDADVRVSGMEADGHRTRFRIEEGDGAAFAVELSLPGRHNVLNAAAAIALARELGVDVAAI
QRALSSFQGIGRRFQVYPDIPLAEGAAALVDDYAHHPRELEATLQAARAAWPERRLVVVFQPHRYSRTRELFDDFARVLS
GTDALVLTEVYAAGEARLPGADGRALASAVRDRGGAQPIFAESLDEVPGLLAGLLRDDDVVLTLGAGSIGGLPAQLGGGL
TAGGGA
>Mature_485_residues
ADGVPAREPRFTAPMDGRSTFGRVRRIHFVGIGGAGMGGIAEVLHNLGFTITGSDVRSGAVVERLVGLGVTVQIGHDPVH
VQGMDAVVVSTAVTEDNPEVQAARQQRIPVVPRAEMLAELMRFRHGVAVAGTHGKTTTTSLLASCLAEGELDPTFVIGGR
LISAGAHARLGAGPYLVAEADESDASFLHLKPMMAAVTNVDADHLGTYGGDFEALRRTFIEFLHHLPFYGLAVLCIDDPE
VRRLRGEIGRPVLTYGFSEDADVRVSGMEADGHRTRFRIEEGDGAAFAVELSLPGRHNVLNAAAAIALARELGVDVAAIQ
RALSSFQGIGRRFQVYPDIPLAEGAAALVDDYAHHPRELEATLQAARAAWPERRLVVVFQPHRYSRTRELFDDFARVLSG
TDALVLTEVYAAGEARLPGADGRALASAVRDRGGAQPIFAESLDEVPGLLAGLLRDDDVVLTLGAGSIGGLPAQLGGGLT
AGGGA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=458, Percent_Identity=57.2052401746725, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1790680, Length=468, Percent_Identity=28.8461538461538, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_HALHL (A1WYU2)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003656.1
- ProteinModelPortal:   A1WYU2
- SMR:   A1WYU2
- STRING:   A1WYU2
- GeneID:   4709978
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2090
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- PhylomeDB:   A1WYU2
- ProtClustDB:   PRK00421
- BioCyc:   HHAL349124:HHAL_2090-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51326; Mature: 51195

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGVPAREPRFTAPMDGRSTFGRVRRIHFVGIGGAGMGGIAEVLHNLGFTITGSDVRSG
CCCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCH
AVVERLVGLGVTVQIGHDPVHVQGMDAVVVSTAVTEDNPEVQAARQQRIPVVPRAEMLAE
HHHHHHHCCCEEEEECCCCEEEECCCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
LMRFRHGVAVAGTHGKTTTTSLLASCLAEGELDPTFVIGGRLISAGAHARLGAGPYLVAE
HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEE
ADESDASFLHLKPMMAAVTNVDADHLGTYGGDFEALRRTFIEFLHHLPFYGLAVLCIDDP
CCCCCCCEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCH
EVRRLRGEIGRPVLTYGFSEDADVRVSGMEADGHRTRFRIEEGDGAAFAVELSLPGRHNV
HHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCHH
LNAAAAIALARELGVDVAAIQRALSSFQGIGRRFQVYPDIPLAEGAAALVDDYAHHPREL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCHHH
EATLQAARAAWPERRLVVVFQPHRYSRTRELFDDFARVLSGTDALVLTEVYAAGEARLPG
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCC
ADGRALASAVRDRGGAQPIFAESLDEVPGLLAGLLRDDDVVLTLGAGSIGGLPAQLGGGL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCC
TAGGGA
CCCCCC
>Mature Secondary Structure 
ADGVPAREPRFTAPMDGRSTFGRVRRIHFVGIGGAGMGGIAEVLHNLGFTITGSDVRSG
CCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCH
AVVERLVGLGVTVQIGHDPVHVQGMDAVVVSTAVTEDNPEVQAARQQRIPVVPRAEMLAE
HHHHHHHCCCEEEEECCCCEEEECCCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
LMRFRHGVAVAGTHGKTTTTSLLASCLAEGELDPTFVIGGRLISAGAHARLGAGPYLVAE
HHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEE
ADESDASFLHLKPMMAAVTNVDADHLGTYGGDFEALRRTFIEFLHHLPFYGLAVLCIDDP
CCCCCCCEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCH
EVRRLRGEIGRPVLTYGFSEDADVRVSGMEADGHRTRFRIEEGDGAAFAVELSLPGRHNV
HHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCHH
LNAAAAIALARELGVDVAAIQRALSSFQGIGRRFQVYPDIPLAEGAAALVDDYAHHPREL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCHHH
EATLQAARAAWPERRLVVVFQPHRYSRTRELFDDFARVLSGTDALVLTEVYAAGEARLPG
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCC
ADGRALASAVRDRGGAQPIFAESLDEVPGLLAGLLRDDDVVLTLGAGSIGGLPAQLGGGL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCC
TAGGGA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA