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The map label for this gene is purE [H]

Identifier: 121998850

GI number: 121998850

Start: 2276678

End: 2277169

Strand: Reverse

Name: purE [H]

Synonym: Hhal_2071

Alternate gene names: 121998850

Gene position: 2277169-2276678 (Counterclockwise)

Preceding gene: 121998851

Following gene: 121998849

Centisome position: 85.02

GC content: 70.73

Gene sequence:

>492_bases
ATGACCGACGCGCAGCCTTTAGTGGGCGTCGTGATGGGCAGCAGTTCCGACTGGGATACCCTCTCCGGCGCCGCCGAGGT
GCTTCGCGATTTCGAGGTGCCCCACGAGGCCCGGGTGGTCTCTGCCCACCGAACCCCGCAACTGATGGCCGACTACGCCG
CCGAGGCCGAGCAGCGTGGCCTGCGGGCGATCATTGCCGGCGCCGGCGGCGCGGCGCATCTGCCCGGCATGCTCGCCGCG
CAGACCATCGTGCCGGTGCTCGGCGTCCCGGTGCAGTCGAAGGCCCTCAACGGCCTCGATTCGCTGCTTTCCATCGTGCA
GATGCCGGCCGGTGTGCCCACGGCGACTTTCGCCATCGGCACCGCCGGGGCGCGCAACGCCGCGCTGTTCGCCGTGGCCA
TGCTGGCCCGCGAGGAGCCCCGCTACGCTGAAGCCCTGAGGGCGTTCCGTGCCCAACAGGCCGAGCGTGTCTACGGGGAG
GAACTCTCGTGA

Upstream 100 bases:

>100_bases
GTGGTGCGGGCCGTCGACGAGATGACCGGCACGCTGCTCAACATCCGTTCCTGATCTTCCCGCCCGTGCTACAATTTTCG
CTTTTGCGAGTGAACCCGCT

Downstream 100 bases:

>100_bases
GCGGCCCGGCGCCGATCCTCCCCGGTGCAGCCATCGGGATCCTCGGCGCCGGTCAGCTCGGGCGCATGCTCGCCATGGCG
GCGCGCCGCTCGGGCTACCG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTDAQPLVGVVMGSSSDWDTLSGAAEVLRDFEVPHEARVVSAHRTPQLMADYAAEAEQRGLRAIIAGAGGAAHLPGMLAA
QTIVPVLGVPVQSKALNGLDSLLSIVQMPAGVPTATFAIGTAGARNAALFAVAMLAREEPRYAEALRAFRAQQAERVYGE
ELS

Sequences:

>Translated_163_residues
MTDAQPLVGVVMGSSSDWDTLSGAAEVLRDFEVPHEARVVSAHRTPQLMADYAAEAEQRGLRAIIAGAGGAAHLPGMLAA
QTIVPVLGVPVQSKALNGLDSLLSIVQMPAGVPTATFAIGTAGARNAALFAVAMLAREEPRYAEALRAFRAQQAERVYGE
ELS
>Mature_162_residues
TDAQPLVGVVMGSSSDWDTLSGAAEVLRDFEVPHEARVVSAHRTPQLMADYAAEAEQRGLRAIIAGAGGAAHLPGMLAAQ
TIVPVLGVPVQSKALNGLDSLLSIVQMPAGVPTATFAIGTAGARNAALFAVAMLAREEPRYAEALRAFRAQQAERVYGEE
LS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=150, Percent_Identity=57.3333333333333, Blast_Score=144, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=54.9019607843137, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16994; Mature: 16862

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAQPLVGVVMGSSSDWDTLSGAAEVLRDFEVPHEARVVSAHRTPQLMADYAAEAEQRG
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
LRAIIAGAGGAAHLPGMLAAQTIVPVLGVPVQSKALNGLDSLLSIVQMPAGVPTATFAIG
CEEEEECCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEC
TAGARNAALFAVAMLAREEPRYAEALRAFRAQQAERVYGEELS
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDAQPLVGVVMGSSSDWDTLSGAAEVLRDFEVPHEARVVSAHRTPQLMADYAAEAEQRG
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
LRAIIAGAGGAAHLPGMLAAQTIVPVLGVPVQSKALNGLDSLLSIVQMPAGVPTATFAIG
CEEEEECCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEC
TAGARNAALFAVAMLAREEPRYAEALRAFRAQQAERVYGEELS
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]