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The map label for this gene is purK [H]

Identifier: 121998849

GI number: 121998849

Start: 2275527

End: 2276681

Strand: Reverse

Name: purK [H]

Synonym: Hhal_2070

Alternate gene names: 121998849

Gene position: 2276681-2275527 (Counterclockwise)

Preceding gene: 121998850

Following gene: 121998848

Centisome position: 85.0

GC content: 72.47

Gene sequence:

>1155_bases
GTGAGCGGCCCGGCGCCGATCCTCCCCGGTGCAGCCATCGGGATCCTCGGCGCCGGTCAGCTCGGGCGCATGCTCGCCAT
GGCGGCGCGCCGCTCGGGCTACCGGGTGCACGTCATCGCCCCCGGCGCCGGGCAGGCGCCGGCCGGGCAGGTGGCGGATC
GGGTGCACGATGCCGAGCCCACGGCGGAGCTGCTGTCCAGCCTGGCCGACGAGGTGAGCGTGCTCACCTACGAGTTCGAG
AACCTGCCGCGTGCGGCCGTCGAGGCCGCCGCCGAGCGCCTGCCGGTGCGGCCATCGCCCCGTGCTCTGGCCACCACCCA
GCACCGTATTCTGGAGAAGACCTTCCTGCGCGAACACGGCCTGCCCGTGGTGCCCTTCGAGGCCGTTCACGGCCCCGAGG
AGGCGGCTGCTGCCGTGGCGCGTATCGGTGCCCCAGCGGTGATCAAGAGCGCCGGGCTGGGCTACGACGGCAAGGGCCAG
GCCCGGGTGGAGAGCGCCGATGAGGTATCGGCCGCGTGGTCGGCTGTCGGCGCCGACGAGGCGGTGGTCGAGGCCTGCGT
CGATCTCGCCATGGAGGTCTCCGTGGTCGCCGCCCGCGGCGTCGATGGCAGCTTCGCCCACTACGGGGTGACCGAGAACC
GCCACCGGCACCACATCCTCGATCTATCGATCGGCGACGCCGAGCTCGACCCGGCGGTGTGCCGGCAGGCCGTGGAGATC
GCCCGAGCGGTGGGCGAGGGTCTCGACGCTGTCGGCACCTACTGCGTGGAGTTCTTCATCGACGGCGCCGGGCGGCTGAT
GGTCAACGAGATCGCCCCGCGCCCGCACAACTCCGGGCATCTGACCATCGAGGGGGCGGCAACCTCGCAGTTCGACCAGC
AGCTGCGTGCCATCTGCGGACTGCCCCTGGGCAGTACCCGGCGGTTGGCCCCGGCGGCCATGGTGAACCTGCTCGGCGAC
GTCTGGGATGCCGGCACGCCGCCGTGGGCCGAGGTCTACCAGGAGCCGACGGCCACCCTGCACCTCTACGGCAAGGGGGC
GCCGAGCCCCGGCCGGAAGATGGGCCATATCACCGTCCTCGGCGAGGACCGGCAGGAGGCCGCCGAGCGCGCCCTGAACC
TGCGCAACCGACTGGCACCCCATGTGGTTTCGTAA

Upstream 100 bases:

>100_bases
TCGCCGTGGCCATGCTGGCCCGCGAGGAGCCCCGCTACGCTGAAGCCCTGAGGGCGTTCCGTGCCCAACAGGCCGAGCGT
GTCTACGGGGAGGAACTCTC

Downstream 100 bases:

>100_bases
TCTCATCCCCTACCGCCTCCGCGACCAGGTCGCCTACGACCCGGAGACTGCGGATCAGCGTCTGGCCGCGCTGGCCTTCA
CCCCCTGCGGGGCGCTGGAG

Product: phosphoribosylaminoimidazole carboxylase, ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSGPAPILPGAAIGILGAGQLGRMLAMAARRSGYRVHVIAPGAGQAPAGQVADRVHDAEPTAELLSSLADEVSVLTYEFE
NLPRAAVEAAAERLPVRPSPRALATTQHRILEKTFLREHGLPVVPFEAVHGPEEAAAAVARIGAPAVIKSAGLGYDGKGQ
ARVESADEVSAAWSAVGADEAVVEACVDLAMEVSVVAARGVDGSFAHYGVTENRHRHHILDLSIGDAELDPAVCRQAVEI
ARAVGEGLDAVGTYCVEFFIDGAGRLMVNEIAPRPHNSGHLTIEGAATSQFDQQLRAICGLPLGSTRRLAPAAMVNLLGD
VWDAGTPPWAEVYQEPTATLHLYGKGAPSPGRKMGHITVLGEDRQEAAERALNLRNRLAPHVVS

Sequences:

>Translated_384_residues
MSGPAPILPGAAIGILGAGQLGRMLAMAARRSGYRVHVIAPGAGQAPAGQVADRVHDAEPTAELLSSLADEVSVLTYEFE
NLPRAAVEAAAERLPVRPSPRALATTQHRILEKTFLREHGLPVVPFEAVHGPEEAAAAVARIGAPAVIKSAGLGYDGKGQ
ARVESADEVSAAWSAVGADEAVVEACVDLAMEVSVVAARGVDGSFAHYGVTENRHRHHILDLSIGDAELDPAVCRQAVEI
ARAVGEGLDAVGTYCVEFFIDGAGRLMVNEIAPRPHNSGHLTIEGAATSQFDQQLRAICGLPLGSTRRLAPAAMVNLLGD
VWDAGTPPWAEVYQEPTATLHLYGKGAPSPGRKMGHITVLGEDRQEAAERALNLRNRLAPHVVS
>Mature_383_residues
SGPAPILPGAAIGILGAGQLGRMLAMAARRSGYRVHVIAPGAGQAPAGQVADRVHDAEPTAELLSSLADEVSVLTYEFEN
LPRAAVEAAAERLPVRPSPRALATTQHRILEKTFLREHGLPVVPFEAVHGPEEAAAAVARIGAPAVIKSAGLGYDGKGQA
RVESADEVSAAWSAVGADEAVVEACVDLAMEVSVVAARGVDGSFAHYGVTENRHRHHILDLSIGDAELDPAVCRQAVEIA
RAVGEGLDAVGTYCVEFFIDGAGRLMVNEIAPRPHNSGHLTIEGAATSQFDQQLRAICGLPLGSTRRLAPAAMVNLLGDV
WDAGTPPWAEVYQEPTATLHLYGKGAPSPGRKMGHITVLGEDRQEAAERALNLRNRLAPHVVS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=352, Percent_Identity=34.375, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1788155, Length=376, Percent_Identity=28.1914893617021, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=376, Percent_Identity=31.3829787234043, Blast_Score=175, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40236; Mature: 40105

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPAPILPGAAIGILGAGQLGRMLAMAARRSGYRVHVIAPGAGQAPAGQVADRVHDAEP
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCH
TAELLSSLADEVSVLTYEFENLPRAAVEAAAERLPVRPSPRALATTQHRILEKTFLREHG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
LPVVPFEAVHGPEEAAAAVARIGAPAVIKSAGLGYDGKGQARVESADEVSAAWSAVGADE
CCCCCHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
AVVEACVDLAMEVSVVAARGVDGSFAHYGVTENRHRHHILDLSIGDAELDPAVCRQAVEI
HHHHHHHHHHHHHHHHEECCCCCCCEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
ARAVGEGLDAVGTYCVEFFIDGAGRLMVNEIAPRPHNSGHLTIEGAATSQFDQQLRAICG
HHHHHCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
LPLGSTRRLAPAAMVNLLGDVWDAGTPPWAEVYQEPTATLHLYGKGAPSPGRKMGHITVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEE
GEDRQEAAERALNLRNRLAPHVVS
CCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SGPAPILPGAAIGILGAGQLGRMLAMAARRSGYRVHVIAPGAGQAPAGQVADRVHDAEP
CCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCH
TAELLSSLADEVSVLTYEFENLPRAAVEAAAERLPVRPSPRALATTQHRILEKTFLREHG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
LPVVPFEAVHGPEEAAAAVARIGAPAVIKSAGLGYDGKGQARVESADEVSAAWSAVGADE
CCCCCHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
AVVEACVDLAMEVSVVAARGVDGSFAHYGVTENRHRHHILDLSIGDAELDPAVCRQAVEI
HHHHHHHHHHHHHHHHEECCCCCCCEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
ARAVGEGLDAVGTYCVEFFIDGAGRLMVNEIAPRPHNSGHLTIEGAATSQFDQQLRAICG
HHHHHCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
LPLGSTRRLAPAAMVNLLGDVWDAGTPPWAEVYQEPTATLHLYGKGAPSPGRKMGHITVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEE
GEDRQEAAERALNLRNRLAPHVVS
CCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]