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The map label for this gene is obg

Identifier: 121998625

GI number: 121998625

Start: 2018788

End: 2019828

Strand: Reverse

Name: obg

Synonym: Hhal_1846

Alternate gene names: 121998625

Gene position: 2019828-2018788 (Counterclockwise)

Preceding gene: 121998626

Following gene: 121998624

Centisome position: 75.41

GC content: 69.16

Gene sequence:

>1041_bases
ATGCGATTCGTCGATGAAGTCACCTTTGTCGTTCGTGCCGGAGACGGTGGCGACGGCTGTGTCCACTTCCGGCGCGAGAA
GTACGTCCCCCGGGGCGGCCCGGACGGCGGCGATGGTGGCCGCGGTGGGAGTGTTTACCTTGAGGGCGATGAAGGCCTGA
ACACACTGGTTGATTACCGCCACGATCGGTTCTTCAGCGCGGAGAGCGGTGAGGCGGGGGGCGGTCGGCAGTGCACAGGG
CGCTCCGGTGTCGACCGTATCCTGCCTGTGCCGGTGGGGACCCTGGTCATGGATGAGGGCACCGGCGAGGTCATCGGCGA
TGTGACCCGCGACGGCGAGCGGCTGCTGGTGGCCGCGGGTGGGCGCGGCGGTCTGGGTAACCTGCACTTCAAGAGTTCCA
CCAACCGCGCGCCGCGTCAGTCCACCGAGGGGACGGCGGGGGAGTCGCGAGAGCTGCGTCTGGAGCTGCAGCTGCTCGCC
GACGTGGGGCTGCTCGGTATGCCCAACGTGGGCAAGTCGACCCTGATCCGCACCATCTCGGCCGCCCGCCCCAAGGTGGC
GGACTACCCCTTCACCACCCTCTATCCGCAGCTCGGCGTGGTCCGCTATGAGGCCCAGCGCTCCTTCGTGGTGGCCGATA
TCCCCGGCATCATCGAGGGGGCCGCGGAGGGCGCGGGGCTCGGGGTGCGTTTCCTCAAGCACCTGAGCCGGACCGGTCTG
CTCCTGCACTTGGTGGACGGCGTTGCCGAGGAGGAGCGTGGCGGGGATCCGGTGGCCGATGCGCAGACCCTGCTCGCCGA
ACTCGAGGCCTTCAGTCCCGAACTGGCGCAGAAACCGCGCTGGTTGGTGGTTAACCGCCTCGACGCTCTGCCCGAGGAGA
TGCGCGCCGAGCGGGTGGCCGAGATCGCCCGGGGGTTGGGCTGGGACGGCCCGGTCTACGGCATCTCCGGGCTCACTGGG
GAGGGCGTGGACCGGCTCTGCGGGGACATCATGAACGATCTGGAGGCGCGACGCAGGGAGGAGGACGGTGAGACGGCGTG
A

Upstream 100 bases:

>100_bases
CCGCGTAAACGGTCGCAGCGACCCAGCCCGGACCTGCAAAGCCCCGCCATGGAGCGGGGCTTTTTTGTATACGGACGCGC
CACGGCGCAGAGGCCCAGCA

Downstream 100 bases:

>100_bases
GGCGCTGCGCCAGGCGCAGCGTTGGGTGATCAAGGTCGGCAGCGCCCTGATTACCGATGACGGGCGAGGGTTGGCCCACG
AGCAGATGAGTGCTTGGGCG

Product: GTP1/OBG domain-containing protein

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MRFVDEVTFVVRAGDGGDGCVHFRREKYVPRGGPDGGDGGRGGSVYLEGDEGLNTLVDYRHDRFFSAESGEAGGGRQCTG
RSGVDRILPVPVGTLVMDEGTGEVIGDVTRDGERLLVAAGGRGGLGNLHFKSSTNRAPRQSTEGTAGESRELRLELQLLA
DVGLLGMPNVGKSTLIRTISAARPKVADYPFTTLYPQLGVVRYEAQRSFVVADIPGIIEGAAEGAGLGVRFLKHLSRTGL
LLHLVDGVAEEERGGDPVADAQTLLAELEAFSPELAQKPRWLVVNRLDALPEEMRAERVAEIARGLGWDGPVYGISGLTG
EGVDRLCGDIMNDLEARRREEDGETA

Sequences:

>Translated_346_residues
MRFVDEVTFVVRAGDGGDGCVHFRREKYVPRGGPDGGDGGRGGSVYLEGDEGLNTLVDYRHDRFFSAESGEAGGGRQCTG
RSGVDRILPVPVGTLVMDEGTGEVIGDVTRDGERLLVAAGGRGGLGNLHFKSSTNRAPRQSTEGTAGESRELRLELQLLA
DVGLLGMPNVGKSTLIRTISAARPKVADYPFTTLYPQLGVVRYEAQRSFVVADIPGIIEGAAEGAGLGVRFLKHLSRTGL
LLHLVDGVAEEERGGDPVADAQTLLAELEAFSPELAQKPRWLVVNRLDALPEEMRAERVAEIARGLGWDGPVYGISGLTG
EGVDRLCGDIMNDLEARRREEDGETA
>Mature_346_residues
MRFVDEVTFVVRAGDGGDGCVHFRREKYVPRGGPDGGDGGRGGSVYLEGDEGLNTLVDYRHDRFFSAESGEAGGGRQCTG
RSGVDRILPVPVGTLVMDEGTGEVIGDVTRDGERLLVAAGGRGGLGNLHFKSSTNRAPRQSTEGTAGESRELRLELQLLA
DVGLLGMPNVGKSTLIRTISAARPKVADYPFTTLYPQLGVVRYEAQRSFVVADIPGIIEGAAEGAGLGVRFLKHLSRTGL
LLHLVDGVAEEERGGDPVADAQTLLAELEAFSPELAQKPRWLVVNRLDALPEEMRAERVAEIARGLGWDGPVYGISGLTG
EGVDRLCGDIMNDLEARRREEDGETA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=344, Percent_Identity=42.4418604651163, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI111955139, Length=368, Percent_Identity=33.4239130434783, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI111955063, Length=204, Percent_Identity=33.8235294117647, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4758796, Length=120, Percent_Identity=38.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=332, Percent_Identity=61.4457831325301, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=31.25, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=327, Percent_Identity=36.085626911315, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=321, Percent_Identity=28.9719626168224, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=130, Percent_Identity=35.3846153846154, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=120, Percent_Identity=35.8333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71981008, Length=129, Percent_Identity=34.1085271317829, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=189, Percent_Identity=35.4497354497354, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=128, Percent_Identity=33.59375, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=121, Percent_Identity=31.404958677686, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI20129375, Length=318, Percent_Identity=38.6792452830189, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=40.0684931506849, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24640873, Length=150, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640877, Length=150, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640875, Length=150, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17981711, Length=129, Percent_Identity=34.1085271317829, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356473, Length=88, Percent_Identity=39.7727272727273, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_HALHL (A1WY48)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003412.1
- ProteinModelPortal:   A1WY48
- SMR:   A1WY48
- STRING:   A1WY48
- GeneID:   4711345
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1846
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   A1WY48
- BioCyc:   HHAL349124:HHAL_1846-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36939; Mature: 36939

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVDEVTFVVRAGDGGDGCVHFRREKYVPRGGPDGGDGGRGGSVYLEGDEGLNTLVDYR
CCCHHCEEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
HDRFFSAESGEAGGGRQCTGRSGVDRILPVPVGTLVMDEGTGEVIGDVTRDGERLLVAAG
HHCEECCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHCCCCCCEEEEEEC
GRGGLGNLHFKSSTNRAPRQSTEGTAGESRELRLELQLLADVGLLGMPNVGKSTLIRTIS
CCCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEEEEEHHHCCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTLYPQLGVVRYEAQRSFVVADIPGIIEGAAEGAGLGVRFLKHLSRTGL
HCCCCCCCCCHHHHCCCCCEEEEECCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHCCH
LLHLVDGVAEEERGGDPVADAQTLLAELEAFSPELAQKPRWLVVNRLDALPEEMRAERVA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHCCHHHHHHHHHH
EIARGLGWDGPVYGISGLTGEGVDRLCGDIMNDLEARRREEDGETA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRFVDEVTFVVRAGDGGDGCVHFRREKYVPRGGPDGGDGGRGGSVYLEGDEGLNTLVDYR
CCCHHCEEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
HDRFFSAESGEAGGGRQCTGRSGVDRILPVPVGTLVMDEGTGEVIGDVTRDGERLLVAAG
HHCEECCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHCCCCCCEEEEEEC
GRGGLGNLHFKSSTNRAPRQSTEGTAGESRELRLELQLLADVGLLGMPNVGKSTLIRTIS
CCCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEEEEEHHHCCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTLYPQLGVVRYEAQRSFVVADIPGIIEGAAEGAGLGVRFLKHLSRTGL
HCCCCCCCCCHHHHCCCCCEEEEECCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHCCH
LLHLVDGVAEEERGGDPVADAQTLLAELEAFSPELAQKPRWLVVNRLDALPEEMRAERVA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHCCHHHHHHHHHH
EIARGLGWDGPVYGISGLTGEGVDRLCGDIMNDLEARRREEDGETA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA