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The map label for this gene is trpA

Identifier: 121998582

GI number: 121998582

Start: 1975161

End: 1975982

Strand: Reverse

Name: trpA

Synonym: Hhal_1803

Alternate gene names: 121998582

Gene position: 1975982-1975161 (Counterclockwise)

Preceding gene: 121998583

Following gene: 121998581

Centisome position: 73.77

GC content: 70.56

Gene sequence:

>822_bases
GTGAGCCGCATCGCTGAACGTTTCCGTGCCTGCCGTTCCGCCGGCCGGACGGCCTTGATTCCCTACATCACCGGTGGCGA
CCCGTCGCCCGATGACACCGTGCGCCTGATGCACGCCCTGGTGGCCGGCGGCGCCGACGTCATCGAGATTGGCGTGCCGT
TCTCCGATCCGATGGCTGACGGTCCTGTGATCCAGGCGGCGTGTGCCCGGGCCCTGGCGGCCGGCACGACGCCGGCGCGG
CTGTTCGAGGTGGTGCGCCGCTTCCGAGAGGAGGATCCGGACACGCCGGTGGTCTTCATGGGCTACGCCAATATCCTCGA
GGCTGCCGGTTATCGCGCCTTCGTTCGCGATGCGGCGGCCGCCGGCGTCGACGGCCTGCTCACCGTTGACCTGCCGCCGG
AGGAGGCCGGGGCGTTGGCCGATGAGGCCCGGGTCCAGGGTGTCGATCTGATCTACCTGGTGGCGCCCAATACGAGCGCC
GAACGCGTGGAGCGGGTCTGTTCGGTGGCCGGCGGTTTTGTCTACGCGGTGGCCCTCAAGGGGGTGACCGGGTCGGCGGA
CCTGGACGCCGGGTTGGTCGGGCAGCAGGTCGCCGGCATCCGTCGGGTGACCGATCTACCGGTGGCCGTCGGATTCGGGG
TGCGTGATCCGCAAAGTGCCGCGGCACTGGCGCCGTGTGCCGACGGCGTGATCGTCGGCAGCGCGTTGGTGCGTATGATT
GGTGAGCACGGGGCGGCGGCGGATCTGCCCGAGCGTCTGCGCGATGCCGTCCTGGCCCTGCGCCGGGCGATGGACGACAC
GACGACGGGGGGTGACTCGTGA

Upstream 100 bases:

>100_bases
TGGCCGCGGAACTCGGCCCGGACGCTGCGCTGGTGGTCAATCTCTCCGGGCGGGGCGATAAGGACATCGCCACGGTCGCG
GCGCAGGAGGGCATCGAGCT

Downstream 100 bases:

>100_bases
GCTGGTTTCAGAAACTCATGCCGCGGCGGATCCGGACCGACGCCGGTCCGCGCAGTCGCAGTGTTCCAGAGGGCCTGTGG
ACCAAGTGCGAGTCCTGCCA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSRIAERFRACRSAGRTALIPYITGGDPSPDDTVRLMHALVAGGADVIEIGVPFSDPMADGPVIQAACARALAAGTTPAR
LFEVVRRFREEDPDTPVVFMGYANILEAAGYRAFVRDAAAAGVDGLLTVDLPPEEAGALADEARVQGVDLIYLVAPNTSA
ERVERVCSVAGGFVYAVALKGVTGSADLDAGLVGQQVAGIRRVTDLPVAVGFGVRDPQSAAALAPCADGVIVGSALVRMI
GEHGAAADLPERLRDAVLALRRAMDDTTTGGDS

Sequences:

>Translated_273_residues
MSRIAERFRACRSAGRTALIPYITGGDPSPDDTVRLMHALVAGGADVIEIGVPFSDPMADGPVIQAACARALAAGTTPAR
LFEVVRRFREEDPDTPVVFMGYANILEAAGYRAFVRDAAAAGVDGLLTVDLPPEEAGALADEARVQGVDLIYLVAPNTSA
ERVERVCSVAGGFVYAVALKGVTGSADLDAGLVGQQVAGIRRVTDLPVAVGFGVRDPQSAAALAPCADGVIVGSALVRMI
GEHGAAADLPERLRDAVLALRRAMDDTTTGGDS
>Mature_272_residues
SRIAERFRACRSAGRTALIPYITGGDPSPDDTVRLMHALVAGGADVIEIGVPFSDPMADGPVIQAACARALAAGTTPARL
FEVVRRFREEDPDTPVVFMGYANILEAAGYRAFVRDAAAAGVDGLLTVDLPPEEAGALADEARVQGVDLIYLVAPNTSAE
RVERVCSVAGGFVYAVALKGVTGSADLDAGLVGQQVAGIRRVTDLPVAVGFGVRDPQSAAALAPCADGVIVGSALVRMIG
EHGAAADLPERLRDAVLALRRAMDDTTTGGDS

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=269, Percent_Identity=33.457249070632, Blast_Score=152, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321412, Length=241, Percent_Identity=39.0041493775934, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_HALHL (A1WY05)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003369.1
- ProteinModelPortal:   A1WY05
- SMR:   A1WY05
- STRING:   A1WY05
- GeneID:   4711014
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1803
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- PhylomeDB:   A1WY05
- BioCyc:   HHAL349124:HHAL_1803-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28169; Mature: 28038

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIAERFRACRSAGRTALIPYITGGDPSPDDTVRLMHALVAGGADVIEIGVPFSDPMAD
CHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQAACARALAAGTTPARLFEVVRRFREEDPDTPVVFMGYANILEAAGYRAFVRDAAA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCHHHHHHHHHH
AGVDGLLTVDLPPEEAGALADEARVQGVDLIYLVAPNTSAERVERVCSVAGGFVYAVALK
CCCCCEEEEECCCHHHCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCHHHEEHHHC
GVTGSADLDAGLVGQQVAGIRRVTDLPVAVGFGVRDPQSAAALAPCADGVIVGSALVRMI
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHH
GEHGAAADLPERLRDAVLALRRAMDDTTTGGDS
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRIAERFRACRSAGRTALIPYITGGDPSPDDTVRLMHALVAGGADVIEIGVPFSDPMAD
HHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQAACARALAAGTTPARLFEVVRRFREEDPDTPVVFMGYANILEAAGYRAFVRDAAA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCHHHHHHHHHH
AGVDGLLTVDLPPEEAGALADEARVQGVDLIYLVAPNTSAERVERVCSVAGGFVYAVALK
CCCCCEEEEECCCHHHCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCHHHEEHHHC
GVTGSADLDAGLVGQQVAGIRRVTDLPVAVGFGVRDPQSAAALAPCADGVIVGSALVRMI
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHH
GEHGAAADLPERLRDAVLALRRAMDDTTTGGDS
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA