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The map label for this gene is nuoD

Identifier: 121998541

GI number: 121998541

Start: 1936496

End: 1937749

Strand: Reverse

Name: nuoD

Synonym: Hhal_1762

Alternate gene names: 121998541

Gene position: 1937749-1936496 (Counterclockwise)

Preceding gene: 121998542

Following gene: 121998540

Centisome position: 72.35

GC content: 64.75

Gene sequence:

>1254_bases
ATGGCTGAGTTCCAGAGCTACACCCTGAACTTCGGCCCGCAGCACCCGGCCGCCCACGGGGTGTTGCGCTTGGTGCTGGA
GATGGAGGGGGAGGCGGTGCGCCGTGCCGACCCCCACATCGGTTTGCTGCACCGGGCCACCGAAAAGCTGGCCGAGTCCA
AGCCTTACAACCAGTCCATCGGCTACATGGACCGGCTCGACTACGTCTCGATGATGTGCAACGAGCACGGCTACGTGCGC
GCCATCGAGAAGCTTTTGGGGATCGAGCCGCCGCTGCGGGCGCAGTACATCCGCACGATGATGGACGAGGTCACCCGCAT
CCTGAATCACTTGATGTGGTTGGGCGGGCACGGCCTCGACGTCGGTGCCATGACCGCGTTCCTGTACACCTTCCGCGAGC
GGGAAGACCTCATGGATGTCTACGAGGCGGTCTCCGGCGCGCGGATGCACGCGACCTACTACCGGCCCGGCGGGGTGCAC
CGGGATCTCCCGGATCAGATGCCGAAGTACGAGCCCTCGGCCTACCGCAGCGACAAAGAGCTGCGCGAGATGAACCGCGC
CCGGGAGGGTTCGGTGCTCGACTTCCTGGACGATTTTTGCGAGCGCTTCCCGGCCTGCGTGGATGAGTACGAGACGCTGC
TGACTGAGAACCGGATCTGGAAGCAGCGGCTGGTGGACATCTGCCCGGTCTCCGCCGAGCGCGCCGTGGAGCTCGGGTTC
ACGGGTCCCCTGCTGCGCGGTTCCGGGGTGGCTTGGGACCTGCGCAAAAAGCAACCCTACGCTGCCTACGACCGGGTCGA
TTTCGACATCCCGGTCGGCGTCAACGGCGACTCCTACGACCGCTACCTGGTGCGCGTCGAGGAGATGCGCCAGTCGGTGC
GCATCATCAAGCAGTGCGTGGATTGGCTGCGAGCCAACCCGGGTCCGGTGCGTATCGACGATCCCAAGGTCACGCCGCCG
ACCCGGGAAGAGATGAAGGACGACATGGAGTCCCTCATCCATCACTTCAAGCTCTTTACCGAGGGGTACTGCACGCCCCC
CGGCGAGGTGTACGCGGCGGTCGAGGCGCCGAAGGGCGAGTTCGGGGTCTACTTGATCTCGGACGGTGCCAACAAGCCGT
ACCGGCTCAAGGTTCGGCCGCCGTGCTATTACCACTTGGCGGCTACCGACGAGATGATTCGCGGCTACATGTTGGCCGAT
GTGGTGACCTTGATCGGCTCGCTGGATGTGGTCTTCGGGGAGGTGGACCGGTGA

Upstream 100 bases:

>100_bases
CCGGTGGAGATCGAGCCGCGGGTGCTGGTGCCGCGGGTCATCCGTGAAGACAACCGCTATGCCGCACCGCAGAAGGCGGA
AGGCACGGAGGGACAAGCCG

Downstream 100 bases:

>100_bases
CGGAGCGGACGGTGGAAGCAGAGATCCTGAACGCGGATCAGCGCCGGCGTATCGATCATTGGCTGGCCAAGTATCCCGAT
GACGAACAGGGCCGGGCATC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEFQSYTLNFGPQHPAAHGVLRLVLEMEGEAVRRADPHIGLLHRATEKLAESKPYNQSIGYMDRLDYVSMMCNEHGYVR
AIEKLLGIEPPLRAQYIRTMMDEVTRILNHLMWLGGHGLDVGAMTAFLYTFREREDLMDVYEAVSGARMHATYYRPGGVH
RDLPDQMPKYEPSAYRSDKELREMNRAREGSVLDFLDDFCERFPACVDEYETLLTENRIWKQRLVDICPVSAERAVELGF
TGPLLRGSGVAWDLRKKQPYAAYDRVDFDIPVGVNGDSYDRYLVRVEEMRQSVRIIKQCVDWLRANPGPVRIDDPKVTPP
TREEMKDDMESLIHHFKLFTEGYCTPPGEVYAAVEAPKGEFGVYLISDGANKPYRLKVRPPCYYHLAATDEMIRGYMLAD
VVTLIGSLDVVFGEVDR

Sequences:

>Translated_417_residues
MAEFQSYTLNFGPQHPAAHGVLRLVLEMEGEAVRRADPHIGLLHRATEKLAESKPYNQSIGYMDRLDYVSMMCNEHGYVR
AIEKLLGIEPPLRAQYIRTMMDEVTRILNHLMWLGGHGLDVGAMTAFLYTFREREDLMDVYEAVSGARMHATYYRPGGVH
RDLPDQMPKYEPSAYRSDKELREMNRAREGSVLDFLDDFCERFPACVDEYETLLTENRIWKQRLVDICPVSAERAVELGF
TGPLLRGSGVAWDLRKKQPYAAYDRVDFDIPVGVNGDSYDRYLVRVEEMRQSVRIIKQCVDWLRANPGPVRIDDPKVTPP
TREEMKDDMESLIHHFKLFTEGYCTPPGEVYAAVEAPKGEFGVYLISDGANKPYRLKVRPPCYYHLAATDEMIRGYMLAD
VVTLIGSLDVVFGEVDR
>Mature_416_residues
AEFQSYTLNFGPQHPAAHGVLRLVLEMEGEAVRRADPHIGLLHRATEKLAESKPYNQSIGYMDRLDYVSMMCNEHGYVRA
IEKLLGIEPPLRAQYIRTMMDEVTRILNHLMWLGGHGLDVGAMTAFLYTFREREDLMDVYEAVSGARMHATYYRPGGVHR
DLPDQMPKYEPSAYRSDKELREMNRAREGSVLDFLDDFCERFPACVDEYETLLTENRIWKQRLVDICPVSAERAVELGFT
GPLLRGSGVAWDLRKKQPYAAYDRVDFDIPVGVNGDSYDRYLVRVEEMRQSVRIIKQCVDWLRANPGPVRIDDPKVTPPT
REEMKDDMESLIHHFKLFTEGYCTPPGEVYAAVEAPKGEFGVYLISDGANKPYRLKVRPPCYYHLAATDEMIRGYMLADV
VTLIGSLDVVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=416, Percent_Identity=58.6538461538462, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI260898743, Length=410, Percent_Identity=57.8048780487805, Blast_Score=478, Evalue=1e-135,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.5365853658537, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789076, Length=419, Percent_Identity=26.7303102625298, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=26.7156862745098, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=54.9397590361446, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=55.1807228915663, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24638644, Length=413, Percent_Identity=59.0799031476998, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221459469, Length=417, Percent_Identity=53.2374100719424, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_HALHL (A1WXW4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003328.1
- ProteinModelPortal:   A1WXW4
- SMR:   A1WXW4
- STRING:   A1WXW4
- GeneID:   4709076
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1762
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   A1WXW4
- ProtClustDB:   PRK06075
- BioCyc:   HHAL349124:HHAL_1762-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47779; Mature: 47648

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFQSYTLNFGPQHPAAHGVLRLVLEMEGEAVRRADPHIGLLHRATEKLAESKPYNQSI
CCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
GYMDRLDYVSMMCNEHGYVRAIEKLLGIEPPLRAQYIRTMMDEVTRILNHLMWLGGHGLD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGAMTAFLYTFREREDLMDVYEAVSGARMHATYYRPGGVHRDLPDQMPKYEPSAYRSDKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCHHHCCHHH
LREMNRAREGSVLDFLDDFCERFPACVDEYETLLTENRIWKQRLVDICPVSAERAVELGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCC
TGPLLRGSGVAWDLRKKQPYAAYDRVDFDIPVGVNGDSYDRYLVRVEEMRQSVRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVRIDDPKVTPPTREEMKDDMESLIHHFKLFTEGYCTPPGEVYAAVEAPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGVYLISDGANKPYRLKVRPPCYYHLAATDEMIRGYMLADVVTLIGSLDVVFGEVDR
EEEEEEECCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEFQSYTLNFGPQHPAAHGVLRLVLEMEGEAVRRADPHIGLLHRATEKLAESKPYNQSI
CCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
GYMDRLDYVSMMCNEHGYVRAIEKLLGIEPPLRAQYIRTMMDEVTRILNHLMWLGGHGLD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGAMTAFLYTFREREDLMDVYEAVSGARMHATYYRPGGVHRDLPDQMPKYEPSAYRSDKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCHHHCCHHH
LREMNRAREGSVLDFLDDFCERFPACVDEYETLLTENRIWKQRLVDICPVSAERAVELGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCC
TGPLLRGSGVAWDLRKKQPYAAYDRVDFDIPVGVNGDSYDRYLVRVEEMRQSVRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DWLRANPGPVRIDDPKVTPPTREEMKDDMESLIHHFKLFTEGYCTPPGEVYAAVEAPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGVYLISDGANKPYRLKVRPPCYYHLAATDEMIRGYMLADVVTLIGSLDVVFGEVDR
EEEEEEECCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA