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The map label for this gene is nuoE [H]

Identifier: 121998540

GI number: 121998540

Start: 1935987

End: 1936499

Strand: Reverse

Name: nuoE [H]

Synonym: Hhal_1761

Alternate gene names: 121998540

Gene position: 1936499-1935987 (Counterclockwise)

Preceding gene: 121998541

Following gene: 121998539

Centisome position: 72.3

GC content: 64.91

Gene sequence:

>513_bases
GTGACGGAGCGGACGGTGGAAGCAGAGATCCTGAACGCGGATCAGCGCCGGCGTATCGATCATTGGCTGGCCAAGTATCC
CGATGACGAACAGGGCCGGGCATCGGCCATCATTCCGGCGCTGCATATCCTGCAGGACGACAACGGCGGCTGGCTGGAGC
GCAGCCACGTGGCGGCGGCGGCGGACTATATCGGCATGCCCCGGGCCAGCGCCTTCGAGGTGGCGACCTTCTATTCCATG
TTCCACCTCGATGAGCCGGTGGGACGACACAAGGTGAATTTCTGCACCAACATCTCGTGCTGCCTCAACGGCGCCGACGA
GCTGGTGGCGTACGCCGAGGAAAAGCTCGGCATCCGTTTGGGTGAGACCACGCCGGACGGGCGCATCACGCTGGTGCGCG
AAGAGGAGTGCCTGGCCGCCTGTACGCGGGCGCCGATGATGGTCGTCGACGGGCACTACTACACCCATCTGACCCGCGAG
CGGATCGACGAGATCCTCGACGGGCTGAGCTGA

Upstream 100 bases:

>100_bases
ACCACTTGGCGGCTACCGACGAGATGATTCGCGGCTACATGTTGGCCGATGTGGTGACCTTGATCGGCTCGCTGGATGTG
GTCTTCGGGGAGGTGGACCG

Downstream 100 bases:

>100_bases
GCCGCAGGGCGCGGAGGGGTCATGGTCAACCAAGTTTGTTATACGACCCTGGGCTATGACGAGCCGTGGAGCCTGGAGAC
CTACCGCAAGGTAGGTGGTT

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTERTVEAEILNADQRRRIDHWLAKYPDDEQGRASAIIPALHILQDDNGGWLERSHVAAAADYIGMPRASAFEVATFYSM
FHLDEPVGRHKVNFCTNISCCLNGADELVAYAEEKLGIRLGETTPDGRITLVREEECLAACTRAPMMVVDGHYYTHLTRE
RIDEILDGLS

Sequences:

>Translated_170_residues
MTERTVEAEILNADQRRRIDHWLAKYPDDEQGRASAIIPALHILQDDNGGWLERSHVAAAADYIGMPRASAFEVATFYSM
FHLDEPVGRHKVNFCTNISCCLNGADELVAYAEEKLGIRLGETTPDGRITLVREEECLAACTRAPMMVVDGHYYTHLTRE
RIDEILDGLS
>Mature_169_residues
TERTVEAEILNADQRRRIDHWLAKYPDDEQGRASAIIPALHILQDDNGGWLERSHVAAAADYIGMPRASAFEVATFYSMF
HLDEPVGRHKVNFCTNISCCLNGADELVAYAEEKLGIRLGETTPDGRITLVREEECLAACTRAPMMVVDGHYYTHLTRER
IDEILDGLS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=160, Percent_Identity=38.75, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1788621, Length=162, Percent_Identity=38.8888888888889, Blast_Score=104, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17561328, Length=160, Percent_Identity=40, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18859877, Length=159, Percent_Identity=35.8490566037736, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21355353, Length=159, Percent_Identity=37.1069182389937, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19107; Mature: 18976

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTVEAEILNADQRRRIDHWLAKYPDDEQGRASAIIPALHILQDDNGGWLERSHVAAA
CCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCEEHHHHHHH
ADYIGMPRASAFEVATFYSMFHLDEPVGRHKVNFCTNISCCLNGADELVAYAEEKLGIRL
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHHHCCHHHHHHHHHHHCCEEE
GETTPDGRITLVREEECLAACTRAPMMVVDGHYYTHLTRERIDEILDGLS
CCCCCCCCEEEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TERTVEAEILNADQRRRIDHWLAKYPDDEQGRASAIIPALHILQDDNGGWLERSHVAAA
CCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCEEHHHHHHH
ADYIGMPRASAFEVATFYSMFHLDEPVGRHKVNFCTNISCCLNGADELVAYAEEKLGIRL
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHHHCCHHHHHHHHHHHCCEEE
GETTPDGRITLVREEECLAACTRAPMMVVDGHYYTHLTRERIDEILDGLS
CCCCCCCCEEEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA