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The map label for this gene is nuoF [H]

Identifier: 121998539

GI number: 121998539

Start: 1934685

End: 1935965

Strand: Reverse

Name: nuoF [H]

Synonym: Hhal_1760

Alternate gene names: 121998539

Gene position: 1935965-1934685 (Counterclockwise)

Preceding gene: 121998540

Following gene: 121998538

Centisome position: 72.28

GC content: 65.81

Gene sequence:

>1281_bases
ATGGTCAACCAAGTTTGTTATACGACCCTGGGCTATGACGAGCCGTGGAGCCTGGAGACCTACCGCAAGGTAGGTGGTTA
CAGGGCCCTCGAGCGCGTGCTGCGCACGCCCATGTCGCCCCAGGAGGTCGTCGACGAGGTCAAGCAGAGCGCCCTGCGCG
GGCGCGGTGGCGCCGGTTTCCCGCCCGGGATCAAGTGGGGGTTCATGCCACGCGACCGTGCCGGGCAGAAGTACCTGATC
TGTAACTCCGACGAATCGGAGCCGGGGACCTGCAAGGATCACGACATCCTGCGCTTCAACCCCCACGCGGTGGTCGAGGG
GATGATCATCGCCGGCTATGCCATGGGGGCGACCGTCGGGTACAACTATCTGCGCGGCGAGTTCCACCACGAGCCCTTCG
AGCGCATGGAACAGGCCGTCGCCGAGGCCCGCAAGGCCGGCTACCTGGGGCGGGATATCCTCGGCTCCGGGTTCGATTTC
GAGCTGCACAACCACTACGGCGCCGGCGCCTACATCTGCGGCGAGGAGTCGGCGCTGATGGAGTCGCTCGAGGGCAAGAA
AGGCCAGCCTCGCTACAAGCCGCCGTTCCCGGCGCAAGTCGGTATCTACGGGAAGCCGACGACGATCAACAACACCGAGA
CCCTTGCCTCGGTGCCGGCGGTGATCCGCAACGGGGCCGAGTGGTTCCTCAACCTCGGCAAGCCCAATAACGGTGGCGAG
AAGATCTTCTCGGTCTCCGGGCACGTGGCGTGTCCGGGCAACTACGAGATCCCCATGGGCACGCCCTTCCGCGAGCTGCT
GGAGATGGCCGGCGGCGTGCGGGCGGGCCATCGGCTCAAGGCGGTGATCCCGGGGGGGAGTTCCACGCCGGTGGTGCCCG
GCGAGACGATGCTCGAGACCGATATGGACTACGACAGCATCGCTGCTGCTGGCTCGATGCTCGGTTCCGGCGCCGTCGTC
GTGATAGACGAGACCACGGATATGGTGCGCATTCTCGCCCGGATCACGCGCTTCTATTACGCCGAGTCGTGCGGGCAGTG
TACGCCGTGTCGTGAGGGCACGGGCTGGCTGTACCGCGCGGTCCAGCGGATCTACGAGGGCCGTGGTACCTACGACGACC
TGCGCATGCTCGAAGAGGTGCCGGGACAGATCGCCGGGCACACCATCTGCGCCTTCGGCGAAGCGGCGGCCACGCCTGTG
CAGAGTTTCATTCAGCATTTCCGGCACGAGTTCGAACACTACATCGAGCACGGTCGATCCCCGGTGGAGGCGGCGGCATG
A

Upstream 100 bases:

>100_bases
GATGATGGTCGTCGACGGGCACTACTACACCCATCTGACCCGCGAGCGGATCGACGAGATCCTCGACGGGCTGAGCTGAG
CCGCAGGGCGCGGAGGGGTC

Downstream 100 bases:

>100_bases
GTGCGAACGAGGAGACGGTCACCATCGAGGTCGATGGCTGCTCCATCGAGGCCCGCAAGGGCGAGATGCTGATTCAGGCC
ACCGACCGTCATGGGATCCA

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MVNQVCYTTLGYDEPWSLETYRKVGGYRALERVLRTPMSPQEVVDEVKQSALRGRGGAGFPPGIKWGFMPRDRAGQKYLI
CNSDESEPGTCKDHDILRFNPHAVVEGMIIAGYAMGATVGYNYLRGEFHHEPFERMEQAVAEARKAGYLGRDILGSGFDF
ELHNHYGAGAYICGEESALMESLEGKKGQPRYKPPFPAQVGIYGKPTTINNTETLASVPAVIRNGAEWFLNLGKPNNGGE
KIFSVSGHVACPGNYEIPMGTPFRELLEMAGGVRAGHRLKAVIPGGSSTPVVPGETMLETDMDYDSIAAAGSMLGSGAVV
VIDETTDMVRILARITRFYYAESCGQCTPCREGTGWLYRAVQRIYEGRGTYDDLRMLEEVPGQIAGHTICAFGEAAATPV
QSFIQHFRHEFEHYIEHGRSPVEAAA

Sequences:

>Translated_426_residues
MVNQVCYTTLGYDEPWSLETYRKVGGYRALERVLRTPMSPQEVVDEVKQSALRGRGGAGFPPGIKWGFMPRDRAGQKYLI
CNSDESEPGTCKDHDILRFNPHAVVEGMIIAGYAMGATVGYNYLRGEFHHEPFERMEQAVAEARKAGYLGRDILGSGFDF
ELHNHYGAGAYICGEESALMESLEGKKGQPRYKPPFPAQVGIYGKPTTINNTETLASVPAVIRNGAEWFLNLGKPNNGGE
KIFSVSGHVACPGNYEIPMGTPFRELLEMAGGVRAGHRLKAVIPGGSSTPVVPGETMLETDMDYDSIAAAGSMLGSGAVV
VIDETTDMVRILARITRFYYAESCGQCTPCREGTGWLYRAVQRIYEGRGTYDDLRMLEEVPGQIAGHTICAFGEAAATPV
QSFIQHFRHEFEHYIEHGRSPVEAAA
>Mature_426_residues
MVNQVCYTTLGYDEPWSLETYRKVGGYRALERVLRTPMSPQEVVDEVKQSALRGRGGAGFPPGIKWGFMPRDRAGQKYLI
CNSDESEPGTCKDHDILRFNPHAVVEGMIIAGYAMGATVGYNYLRGEFHHEPFERMEQAVAEARKAGYLGRDILGSGFDF
ELHNHYGAGAYICGEESALMESLEGKKGQPRYKPPFPAQVGIYGKPTTINNTETLASVPAVIRNGAEWFLNLGKPNNGGE
KIFSVSGHVACPGNYEIPMGTPFRELLEMAGGVRAGHRLKAVIPGGSSTPVVPGETMLETDMDYDSIAAAGSMLGSGAVV
VIDETTDMVRILARITRFYYAESCGQCTPCREGTGWLYRAVQRIYEGRGTYDDLRMLEEVPGQIAGHTICAFGEAAATPV
QSFIQHFRHEFEHYIEHGRSPVEAAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=414, Percent_Identity=47.5845410628019, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI260656005, Length=414, Percent_Identity=47.5845410628019, Blast_Score=396, Evalue=1e-110,
Organism=Escherichia coli, GI1788620, Length=407, Percent_Identity=45.7002457002457, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17531727, Length=376, Percent_Identity=51.3297872340426, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19920794, Length=414, Percent_Identity=49.5169082125604, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45550452, Length=423, Percent_Identity=47.0449172576832, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24653819, Length=381, Percent_Identity=36.745406824147, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24653817, Length=356, Percent_Identity=35.3932584269663, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46708; Mature: 46708

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNQVCYTTLGYDEPWSLETYRKVGGYRALERVLRTPMSPQEVVDEVKQSALRGRGGAGF
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PPGIKWGFMPRDRAGQKYLICNSDESEPGTCKDHDILRFNPHAVVEGMIIAGYAMGATVG
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
YNYLRGEFHHEPFERMEQAVAEARKAGYLGRDILGSGFDFELHNHYGAGAYICGEESALM
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCCEEEECCHHHHH
ESLEGKKGQPRYKPPFPAQVGIYGKPTTINNTETLASVPAVIRNGAEWFLNLGKPNNGGE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCCCCCCCC
KIFSVSGHVACPGNYEIPMGTPFRELLEMAGGVRAGHRLKAVIPGGSSTPVVPGETMLET
EEEEECCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHC
DMDYDSIAAAGSMLGSGAVVVIDETTDMVRILARITRFYYAESCGQCTPCREGTGWLYRA
CCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VQRIYEGRGTYDDLRMLEEVPGQIAGHTICAFGEAAATPVQSFIQHFRHEFEHYIEHGRS
HHHHHHCCCCHHHHHHHHHCCHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEAAA
CHHHCC
>Mature Secondary Structure
MVNQVCYTTLGYDEPWSLETYRKVGGYRALERVLRTPMSPQEVVDEVKQSALRGRGGAGF
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PPGIKWGFMPRDRAGQKYLICNSDESEPGTCKDHDILRFNPHAVVEGMIIAGYAMGATVG
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
YNYLRGEFHHEPFERMEQAVAEARKAGYLGRDILGSGFDFELHNHYGAGAYICGEESALM
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCCEEEECCHHHHH
ESLEGKKGQPRYKPPFPAQVGIYGKPTTINNTETLASVPAVIRNGAEWFLNLGKPNNGGE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCCCCCCCC
KIFSVSGHVACPGNYEIPMGTPFRELLEMAGGVRAGHRLKAVIPGGSSTPVVPGETMLET
EEEEECCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHC
DMDYDSIAAAGSMLGSGAVVVIDETTDMVRILARITRFYYAESCGQCTPCREGTGWLYRA
CCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VQRIYEGRGTYDDLRMLEEVPGQIAGHTICAFGEAAATPVQSFIQHFRHEFEHYIEHGRS
HHHHHHCCCCHHHHHHHHHCCHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEAAA
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA