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The map label for this gene is nuoI

Identifier: 121998536

GI number: 121998536

Start: 1930749

End: 1931240

Strand: Reverse

Name: nuoI

Synonym: Hhal_1757

Alternate gene names: 121998536

Gene position: 1931240-1930749 (Counterclockwise)

Preceding gene: 121998537

Following gene: 121998535

Centisome position: 72.1

GC content: 65.85

Gene sequence:

>492_bases
ATGAGACCGCTGAACGACTATCTGAACAGCTTCCTGTTCACGGAGCTGCTGCGCGGGCTGCGGCTGACTGCGCGCCACAT
GGTATTCCGGCGCAGTATCACGCTGGAGTTCCCGGAGGAGCGGGCGCCGAAGTCGCCGCGATTCCGGGGGCACCTCGCCC
TGCGCCGCTACCCCAACGGCGAGGAGCGCTGCATCGCCTGCAAGCTCTGCGAGGCGGTGTGCCCGGCGCTGGCGATCACC
ATTGATTCGCACCAGCGCGCCGACGGCACGCGGCGAACCACTCGCTACGACATCGACATGTTCAAGTGCATCTACTGCGG
CTTCTGCGAGGAGTCGTGCCCGGTGGACTCCATCGTCCTGACCCGGCTCGACACCTTCCACATGGAGCGTCGTGACGAGC
GGGTCGCCGATAAGCAGAAGTTGCTGGCCATGGGTGACAAGTACGAGAGCCAGCTGGCGGCCGATCGCGCCGCCGATGCG
CCCTACCGGTAA

Upstream 100 bases:

>100_bases
GGCTGGAAGGTTCTGATCCCGGGCACCGTGGTGTGGCTGGTGGTGCTGACTGGCCTGGTCTACGGCGGCGTCGGTCCTTG
GTTCTGATGGGGGTACGGTC

Downstream 100 bases:

>100_bases
TGGGAGCCTCGGGCTTATGGAACAGGTGATCTTCTACATCTTCGCCGGGGTGCTGCTGTTCGCAGCGACCATGGTGATCT
CGGTGCGCAACCCGGTCCAC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MRPLNDYLNSFLFTELLRGLRLTARHMVFRRSITLEFPEERAPKSPRFRGHLALRRYPNGEERCIACKLCEAVCPALAIT
IDSHQRADGTRRTTRYDIDMFKCIYCGFCEESCPVDSIVLTRLDTFHMERRDERVADKQKLLAMGDKYESQLAADRAADA
PYR

Sequences:

>Translated_163_residues
MRPLNDYLNSFLFTELLRGLRLTARHMVFRRSITLEFPEERAPKSPRFRGHLALRRYPNGEERCIACKLCEAVCPALAIT
IDSHQRADGTRRTTRYDIDMFKCIYCGFCEESCPVDSIVLTRLDTFHMERRDERVADKQKLLAMGDKYESQLAADRAADA
PYR
>Mature_163_residues
MRPLNDYLNSFLFTELLRGLRLTARHMVFRRSITLEFPEERAPKSPRFRGHLALRRYPNGEERCIACKLCEAVCPALAIT
IDSHQRADGTRRTTRYDIDMFKCIYCGFCEESCPVDSIVLTRLDTFHMERRDERVADKQKLLAMGDKYESQLAADRAADA
PYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=154, Percent_Identity=59.7402597402597, Blast_Score=191, Evalue=3e-49,
Organism=Escherichia coli, GI1788617, Length=133, Percent_Identity=35.3383458646617, Blast_Score=94, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17555194, Length=160, Percent_Identity=55, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17864306, Length=155, Percent_Identity=58.7096774193548, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_HALHL (A1WXV9)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003323.1
- ProteinModelPortal:   A1WXV9
- SMR:   A1WXV9
- STRING:   A1WXV9
- GeneID:   4710514
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1757
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   NKAADAP
- PhylomeDB:   A1WXV9
- ProtClustDB:   PRK05888
- BioCyc:   HHAL349124:HHAL_1757-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18983; Mature: 18983

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLNDYLNSFLFTELLRGLRLTARHMVFRRSITLEFPEERAPKSPRFRGHLALRRYPNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHCCCCCCCCCCCEEEECCCCC
EERCIACKLCEAVCPALAITIDSHQRADGTRRTTRYDIDMFKCIYCGFCEESCPVDSIVL
CHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHH
TRLDTFHMERRDERVADKQKLLAMGDKYESQLAADRAADAPYR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRPLNDYLNSFLFTELLRGLRLTARHMVFRRSITLEFPEERAPKSPRFRGHLALRRYPNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHCCCCCCCCCCCEEEECCCCC
EERCIACKLCEAVCPALAITIDSHQRADGTRRTTRYDIDMFKCIYCGFCEESCPVDSIVL
CHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHH
TRLDTFHMERRDERVADKQKLLAMGDKYESQLAADRAADAPYR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA