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The map label for this gene is nuoH

Identifier: 121998537

GI number: 121998537

Start: 1931254

End: 1932267

Strand: Reverse

Name: nuoH

Synonym: Hhal_1758

Alternate gene names: 121998537

Gene position: 1932267-1931254 (Counterclockwise)

Preceding gene: 121998538

Following gene: 121998536

Centisome position: 72.14

GC content: 63.91

Gene sequence:

>1014_bases
ATGTACGAGACACTCTTCTGGCAGTTCGCCAAGATCTGGGCCGTCCTGATCCCGCTGTTCCTGGCCGTGGCCTATTTCAC
CTACGTCGAGCGGCGGGTGATTGGCCACATGCAGGATCGCCGCGGGCCTAACCGCGTCGGCCCCCGCGGGTTGCTGCAGC
CCATTGCCGATGCGCTGAAGCTCCTGTTCAAAGAGATCACCATCCCCACCTACGCCAGCCGGACGCTGTTCCTGATCGCA
CCGGCGATGGCCATCATGCCGGCGCTGGCGGCCTGGGCGGTGATCCCCTTCGATGATGGCCTGGTGGTTGCGGACATCAA
TGCGGGGCTGCTCTACATCCTGGCGATGACCTCGCTGGGCGTGTACGGATTGATCATCGCCGGTTGGGCTTCCAACTCCA
AGTACGCCCTGCTCGGTACGCTGCGGGCCTCGGCTCAGGTCGTCTCCTATGAGATCGCGATGGGTTTCGCGTTGGTGGGC
GTGCTGATCGCTGCCGGGACTATGAACCTGAGCGGCATCGTCCATGCCCAGGCTGGCCCTTTTTGGGAGTGGTTCTGGCT
GCCGTTGTTGCCCCTGTTCCTGATCTACTGGATCTCGGGCGTGGCCGAGACCAACCGGGCACCGTTCGACATCGCCGAGG
GTGAGTCGGAGATCGTCGCCGGGTTCCACGTGGAGTACTCGGGGATGGCCTTTGCGGTCTTTTTCCTGGCCGAGTACGCC
AACATGCTGTTGATCTCGTTCCTGGCGGCGACCCTGTTCCTGGGCGGTTGGCACTCACCCTTCGAGGGGCTGCCGGTCCT
CGGGCCGGCCTTTGACTGGGTCCCCGGGATCGTGTGGCTGTTCGCGAAGGCCGCTTTCTTCGCCTTCTGCTATCTGTGGT
TCCGCGCTACCTTCCCGCGCTACCGCTACGACCAGCTCATGCGGCTGGGCTGGAAGGTTCTGATCCCGGGCACCGTGGTG
TGGCTGGTGGTGCTGACTGGCCTGGTCTACGGCGGCGTCGGTCCTTGGTTCTGA

Upstream 100 bases:

>100_bases
CGCCGGGCTGGATGAGCGCGCGGCGCTCGGCGGCCCGTACGGGACCGTCTCGCTGGAAGCGCTCTAGGCCGCAGGGCCGC
AGAAAAGGACGATCGAGGGC

Downstream 100 bases:

>100_bases
TGGGGGTACGGTCATGAGACCGCTGAACGACTATCTGAACAGCTTCCTGTTCACGGAGCTGCTGCGCGGGCTGCGGCTGA
CTGCGCGCCACATGGTATTC

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MYETLFWQFAKIWAVLIPLFLAVAYFTYVERRVIGHMQDRRGPNRVGPRGLLQPIADALKLLFKEITIPTYASRTLFLIA
PAMAIMPALAAWAVIPFDDGLVVADINAGLLYILAMTSLGVYGLIIAGWASNSKYALLGTLRASAQVVSYEIAMGFALVG
VLIAAGTMNLSGIVHAQAGPFWEWFWLPLLPLFLIYWISGVAETNRAPFDIAEGESEIVAGFHVEYSGMAFAVFFLAEYA
NMLLISFLAATLFLGGWHSPFEGLPVLGPAFDWVPGIVWLFAKAAFFAFCYLWFRATFPRYRYDQLMRLGWKVLIPGTVV
WLVVLTGLVYGGVGPWF

Sequences:

>Translated_337_residues
MYETLFWQFAKIWAVLIPLFLAVAYFTYVERRVIGHMQDRRGPNRVGPRGLLQPIADALKLLFKEITIPTYASRTLFLIA
PAMAIMPALAAWAVIPFDDGLVVADINAGLLYILAMTSLGVYGLIIAGWASNSKYALLGTLRASAQVVSYEIAMGFALVG
VLIAAGTMNLSGIVHAQAGPFWEWFWLPLLPLFLIYWISGVAETNRAPFDIAEGESEIVAGFHVEYSGMAFAVFFLAEYA
NMLLISFLAATLFLGGWHSPFEGLPVLGPAFDWVPGIVWLFAKAAFFAFCYLWFRATFPRYRYDQLMRLGWKVLIPGTVV
WLVVLTGLVYGGVGPWF
>Mature_337_residues
MYETLFWQFAKIWAVLIPLFLAVAYFTYVERRVIGHMQDRRGPNRVGPRGLLQPIADALKLLFKEITIPTYASRTLFLIA
PAMAIMPALAAWAVIPFDDGLVVADINAGLLYILAMTSLGVYGLIIAGWASNSKYALLGTLRASAQVVSYEIAMGFALVG
VLIAAGTMNLSGIVHAQAGPFWEWFWLPLLPLFLIYWISGVAETNRAPFDIAEGESEIVAGFHVEYSGMAFAVFFLAEYA
NMLLISFLAATLFLGGWHSPFEGLPVLGPAFDWVPGIVWLFAKAAFFAFCYLWFRATFPRYRYDQLMRLGWKVLIPGTVV
WLVVLTGLVYGGVGPWF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=302, Percent_Identity=44.0397350993377, Blast_Score=240, Evalue=1e-63,
Organism=Escherichia coli, GI1788618, Length=306, Percent_Identity=43.4640522875817, Blast_Score=261, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_HALHL (A1WXW0)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003324.1
- STRING:   A1WXW0
- GeneID:   4710515
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1758
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- PhylomeDB:   A1WXW0
- ProtClustDB:   CLSK727522
- BioCyc:   HHAL349124:HHAL_1758-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37434; Mature: 37434

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b8e5e50)-; HASH(0x1b7d63b4)-; HASH(0x1aa84440)-; HASH(0x1b2d6630)-; HASH(0x1ad2e0d8)-; HASH(0x187b1954)-; HASH(0x1a6d5524)-; HASH(0x1b37d22c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYETLFWQFAKIWAVLIPLFLAVAYFTYVERRVIGHMQDRRGPNRVGPRGLLQPIADALK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LLFKEITIPTYASRTLFLIAPAMAIMPALAAWAVIPFDDGLVVADINAGLLYILAMTSLG
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHHH
VYGLIIAGWASNSKYALLGTLRASAQVVSYEIAMGFALVGVLIAAGTMNLSGIVHAQAGP
HHHHHEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
FWEWFWLPLLPLFLIYWISGVAETNRAPFDIAEGESEIVAGFHVEYSGMAFAVFFLAEYA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHH
NMLLISFLAATLFLGGWHSPFEGLPVLGPAFDWVPGIVWLFAKAAFFAFCYLWFRATFPR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YRYDQLMRLGWKVLIPGTVVWLVVLTGLVYGGVGPWF
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MYETLFWQFAKIWAVLIPLFLAVAYFTYVERRVIGHMQDRRGPNRVGPRGLLQPIADALK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LLFKEITIPTYASRTLFLIAPAMAIMPALAAWAVIPFDDGLVVADINAGLLYILAMTSLG
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHHH
VYGLIIAGWASNSKYALLGTLRASAQVVSYEIAMGFALVGVLIAAGTMNLSGIVHAQAGP
HHHHHEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
FWEWFWLPLLPLFLIYWISGVAETNRAPFDIAEGESEIVAGFHVEYSGMAFAVFFLAEYA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHH
NMLLISFLAATLFLGGWHSPFEGLPVLGPAFDWVPGIVWLFAKAAFFAFCYLWFRATFPR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YRYDQLMRLGWKVLIPGTVVWLVVLTGLVYGGVGPWF
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA