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The map label for this gene is nuoL [H]

Identifier: 121998533

GI number: 121998533

Start: 1927793

End: 1929763

Strand: Reverse

Name: nuoL [H]

Synonym: Hhal_1754

Alternate gene names: 121998533

Gene position: 1929763-1927793 (Counterclockwise)

Preceding gene: 121998534

Following gene: 121998532

Centisome position: 72.05

GC content: 65.5

Gene sequence:

>1971_bases
ATGGAGACGGTCCTCTACGCCATCGTCCTCTTCCCGCTGGCCGCGGCTGCCATCGCCGGCCTGGCCGGCGGCTGGGTCGG
CCGTGCCGGCGCCCACTGGGTGACCATTCTCGGTGTCGCCATCTCCTGTGCCCTGTCGTTCTGGGTGCTCTACGGCCTGA
TCTGGGGCGACCTGGAGCCGGTGGACTTCACCGTCTACACGTGGGCCTCGGTGGGCGACCTGAGCTTCGAGATCGGCTTC
CTGGTCGACCGGCTCACCGCGGTGATGATGGCCACCGTGACCTTTGTCGCGCTGATGGTTCATATCTACACCATCGGCTA
CATGCACGACGACCCAGGCTATCAGCGGTTTTTCAGCTACATCGCGCTGTTCACCTTCGCCATGCTGATGCTGGTCATGG
CGAACAACCTGCTGCAGCTGTTCTTTGCCTGGGAGGCCGTCGGCCTGGTCTCGTACCTGCTGATCGGCTTCTGGTACACC
CGCGAGAGCGCCATCTTCGCCAACCTCAAGGCGTTCCTGGTTAATCGTGTGGGCGACCTGGGGCTGCTGCTGGGGATCGC
CGTGCTCGCCGGGGCCTTCGGTACGCTCCACTACGGCGAGATCTTCGCGGCGGTGGAAGCCGATCCCGGCCGGACGCTGA
ACCTCTTCGGCGCCGCCGAGTGGAGCCTGGTGACGGTCGCCGCGCTGCTGATCTTCATCGGCTGCATGGGCAAGTCGGCC
CAGGTCCCGCTCCACGTGTGGCTGCCCGACTCCATGGAGGGCCCGACGCCCATCTCGGCCCTAATCCACGCCGCCACCAT
GGTGACCGCCGGCATCTTCCTGGTCGCCCGCATGTCGCCGGTCTTCGAGCTGTCCACCGTGGCGCTGACCGTGGTCCTGG
TGGTCGGTGCGCTGACGGCCTTCTTCATGGGGCTGATCGGCCTGGTGCAGAACGACATCAAGCGGGTCATCGCCTATTCG
ACGCTCTCGCAACTCGGCTACATGGTCGCCGCCTTGGGCGTCTCGGCCTACGCCGCCGGTGTCTTCCATCTGTTCACCCA
CGCCTTCTTCAAGGCGCTGCTCTTCCTCGGTGCCGGGTCGGTCATCATCGCCCTGCATCACGAGCAGGACATGCGCAAGA
TGGGGGGGCTGGCCAAGTACATGCCGGTGACCTATGTCGCCATGCTGCTCGGCACCCTGGCGCTGATCGGCATCCCGGGC
TTCTCCGGTTTCTTCTCCAAGGACGCCATCATCGAGGCCGTGGGGTACTCCGCCGGGGGCTGGGCGACCTTCGCCTACTG
GTTGCTGGTGCTCGGCGTCTTCGTCACTGCGCTCTACAGTTTCCGGCTGCTGTTCATGGTCTTTCACGGCGAGGAGCGCA
TGGACGAGCACGCCCGCAAGCATCTGCATGAGAGCCCACTGGTGGTTACCGTACCGCTGGTGTTGCTGGCTGTGCCCTCG
GTGCTGATCGGCCTGTTCACCTTCGGGCCGATGGTCATGGGCGATTTCTTCTACGCCGATGGCTCGATCCGCGTGCTCGC
CGAACAGACCGGGCTGGACCGCCTGGCCGAAGGATATAACGGCGTGCTGGGCTTCATGGCCCACGCGCTGGTGACACCGG
TGCTCTACCTGGTGCTGGCCGGGGTCTTCGTCGCCTGGCTGCTCTACCTGCGCCGCCCCGACCTGCGGGCACAGGTGGTG
GCGCCCCTGCGGCCGCTGGAGCGGGTGCTCGAGCACAAGTACGGGTTCGACTGGCTCTATATCCGCGGCTTCACGGATGG
CGGTCGGGCGTTCGCCGGCCTGCTGTCGAAGGCCGGGGATCGCTGGCTGATCGACGGGCTGCTGGTCAACGGTACGGCCC
GTTTGATCGGTCGTATCGCCGCCGGGGCGCGGTACTCGCAGACCGGGTACCTGTACCACTACGCCTTCGTCATGGTCATC
GGCGTGCTGCTGCTGATCTCATTCTTCGTTGTGCGAACGCTGTTCGCCTAG

Upstream 100 bases:

>100_bases
GGCGGCGGAGGCGGCCATCGGTCTGGCCATCGTCGTGGTCCTGTTCCGTTCACGCGGTGACATCAACGTCGCCGCCATGG
ATGCGATGAAGGGGTAAGCC

Downstream 100 bases:

>100_bases
TGCGCGGCTTCGGGACGGACGCGCAAGAACGCAGGGGAAGAACGGATGTTCGACGGTTGGTTGCTTAGCCTGATTATCTG
GCTGCCGATCCTCGGCGGTG

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
METVLYAIVLFPLAAAAIAGLAGGWVGRAGAHWVTILGVAISCALSFWVLYGLIWGDLEPVDFTVYTWASVGDLSFEIGF
LVDRLTAVMMATVTFVALMVHIYTIGYMHDDPGYQRFFSYIALFTFAMLMLVMANNLLQLFFAWEAVGLVSYLLIGFWYT
RESAIFANLKAFLVNRVGDLGLLLGIAVLAGAFGTLHYGEIFAAVEADPGRTLNLFGAAEWSLVTVAALLIFIGCMGKSA
QVPLHVWLPDSMEGPTPISALIHAATMVTAGIFLVARMSPVFELSTVALTVVLVVGALTAFFMGLIGLVQNDIKRVIAYS
TLSQLGYMVAALGVSAYAAGVFHLFTHAFFKALLFLGAGSVIIALHHEQDMRKMGGLAKYMPVTYVAMLLGTLALIGIPG
FSGFFSKDAIIEAVGYSAGGWATFAYWLLVLGVFVTALYSFRLLFMVFHGEERMDEHARKHLHESPLVVTVPLVLLAVPS
VLIGLFTFGPMVMGDFFYADGSIRVLAEQTGLDRLAEGYNGVLGFMAHALVTPVLYLVLAGVFVAWLLYLRRPDLRAQVV
APLRPLERVLEHKYGFDWLYIRGFTDGGRAFAGLLSKAGDRWLIDGLLVNGTARLIGRIAAGARYSQTGYLYHYAFVMVI
GVLLLISFFVVRTLFA

Sequences:

>Translated_656_residues
METVLYAIVLFPLAAAAIAGLAGGWVGRAGAHWVTILGVAISCALSFWVLYGLIWGDLEPVDFTVYTWASVGDLSFEIGF
LVDRLTAVMMATVTFVALMVHIYTIGYMHDDPGYQRFFSYIALFTFAMLMLVMANNLLQLFFAWEAVGLVSYLLIGFWYT
RESAIFANLKAFLVNRVGDLGLLLGIAVLAGAFGTLHYGEIFAAVEADPGRTLNLFGAAEWSLVTVAALLIFIGCMGKSA
QVPLHVWLPDSMEGPTPISALIHAATMVTAGIFLVARMSPVFELSTVALTVVLVVGALTAFFMGLIGLVQNDIKRVIAYS
TLSQLGYMVAALGVSAYAAGVFHLFTHAFFKALLFLGAGSVIIALHHEQDMRKMGGLAKYMPVTYVAMLLGTLALIGIPG
FSGFFSKDAIIEAVGYSAGGWATFAYWLLVLGVFVTALYSFRLLFMVFHGEERMDEHARKHLHESPLVVTVPLVLLAVPS
VLIGLFTFGPMVMGDFFYADGSIRVLAEQTGLDRLAEGYNGVLGFMAHALVTPVLYLVLAGVFVAWLLYLRRPDLRAQVV
APLRPLERVLEHKYGFDWLYIRGFTDGGRAFAGLLSKAGDRWLIDGLLVNGTARLIGRIAAGARYSQTGYLYHYAFVMVI
GVLLLISFFVVRTLFA
>Mature_656_residues
METVLYAIVLFPLAAAAIAGLAGGWVGRAGAHWVTILGVAISCALSFWVLYGLIWGDLEPVDFTVYTWASVGDLSFEIGF
LVDRLTAVMMATVTFVALMVHIYTIGYMHDDPGYQRFFSYIALFTFAMLMLVMANNLLQLFFAWEAVGLVSYLLIGFWYT
RESAIFANLKAFLVNRVGDLGLLLGIAVLAGAFGTLHYGEIFAAVEADPGRTLNLFGAAEWSLVTVAALLIFIGCMGKSA
QVPLHVWLPDSMEGPTPISALIHAATMVTAGIFLVARMSPVFELSTVALTVVLVVGALTAFFMGLIGLVQNDIKRVIAYS
TLSQLGYMVAALGVSAYAAGVFHLFTHAFFKALLFLGAGSVIIALHHEQDMRKMGGLAKYMPVTYVAMLLGTLALIGIPG
FSGFFSKDAIIEAVGYSAGGWATFAYWLLVLGVFVTALYSFRLLFMVFHGEERMDEHARKHLHESPLVVTVPLVLLAVPS
VLIGLFTFGPMVMGDFFYADGSIRVLAEQTGLDRLAEGYNGVLGFMAHALVTPVLYLVLAGVFVAWLLYLRRPDLRAQVV
APLRPLERVLEHKYGFDWLYIRGFTDGGRAFAGLLSKAGDRWLIDGLLVNGTARLIGRIAAGARYSQTGYLYHYAFVMVI
GVLLLISFFVVRTLFA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=422, Percent_Identity=38.8625592417062, Blast_Score=295, Evalue=1e-79,
Organism=Escherichia coli, GI1788614, Length=585, Percent_Identity=41.1965811965812, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788829, Length=447, Percent_Identity=31.0961968680089, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788827, Length=443, Percent_Identity=27.9909706546275, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=29.971181556196, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI2367154, Length=428, Percent_Identity=26.6355140186916, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI145693160, Length=395, Percent_Identity=26.8354430379747, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788613, Length=294, Percent_Identity=26.8707482993197, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71447; Mature: 71447

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVLYAIVLFPLAAAAIAGLAGGWVGRAGAHWVTILGVAISCALSFWVLYGLIWGDLEP
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDFTVYTWASVGDLSFEIGFLVDRLTAVMMATVTFVALMVHIYTIGYMHDDPGYQRFFSY
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHHHH
IALFTFAMLMLVMANNLLQLFFAWEAVGLVSYLLIGFWYTRESAIFANLKAFLVNRVGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLLGIAVLAGAFGTLHYGEIFAAVEADPGRTLNLFGAAEWSLVTVAALLIFIGCMGKSA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCC
QVPLHVWLPDSMEGPTPISALIHAATMVTAGIFLVARMSPVFELSTVALTVVLVVGALTA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FFMGLIGLVQNDIKRVIAYSTLSQLGYMVAALGVSAYAAGVFHLFTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VIIALHHEQDMRKMGGLAKYMPVTYVAMLLGTLALIGIPGFSGFFSKDAIIEAVGYSAGG
EEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCH
WATFAYWLLVLGVFVTALYSFRLLFMVFHGEERMDEHARKHLHESPLVVTVPLVLLAVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VLIGLFTFGPMVMGDFFYADGSIRVLAEQTGLDRLAEGYNGVLGFMAHALVTPVLYLVLA
HHHHHHHHHHHHHHHHEEECCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVFVAWLLYLRRPDLRAQVVAPLRPLERVLEHKYGFDWLYIRGFTDGGRAFAGLLSKAGD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCC
RWLIDGLLVNGTARLIGRIAAGARYSQTGYLYHYAFVMVIGVLLLISFFVVRTLFA
CEEEHHEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METVLYAIVLFPLAAAAIAGLAGGWVGRAGAHWVTILGVAISCALSFWVLYGLIWGDLEP
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDFTVYTWASVGDLSFEIGFLVDRLTAVMMATVTFVALMVHIYTIGYMHDDPGYQRFFSY
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHHHH
IALFTFAMLMLVMANNLLQLFFAWEAVGLVSYLLIGFWYTRESAIFANLKAFLVNRVGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLLGIAVLAGAFGTLHYGEIFAAVEADPGRTLNLFGAAEWSLVTVAALLIFIGCMGKSA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCC
QVPLHVWLPDSMEGPTPISALIHAATMVTAGIFLVARMSPVFELSTVALTVVLVVGALTA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FFMGLIGLVQNDIKRVIAYSTLSQLGYMVAALGVSAYAAGVFHLFTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VIIALHHEQDMRKMGGLAKYMPVTYVAMLLGTLALIGIPGFSGFFSKDAIIEAVGYSAGG
EEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCH
WATFAYWLLVLGVFVTALYSFRLLFMVFHGEERMDEHARKHLHESPLVVTVPLVLLAVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VLIGLFTFGPMVMGDFFYADGSIRVLAEQTGLDRLAEGYNGVLGFMAHALVTPVLYLVLA
HHHHHHHHHHHHHHHHEEECCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVFVAWLLYLRRPDLRAQVVAPLRPLERVLEHKYGFDWLYIRGFTDGGRAFAGLLSKAGD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCC
RWLIDGLLVNGTARLIGRIAAGARYSQTGYLYHYAFVMVIGVLLLISFFVVRTLFA
CEEEHHEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]