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The map label for this gene is ahcY

Identifier: 121998454

GI number: 121998454

Start: 1827412

End: 1828704

Strand: Reverse

Name: ahcY

Synonym: Hhal_1675

Alternate gene names: 121998454

Gene position: 1828704-1827412 (Counterclockwise)

Preceding gene: 121998455

Following gene: 121998453

Centisome position: 68.27

GC content: 63.73

Gene sequence:

>1293_bases
ATGAGTAATCAAGACTACAAGGTTGCGGATATCTCCCTGGCCGACTGGGGCCGTAAGGAGATCAAGATCGCCGAGAGCGA
GATGCCGGGTCTGATGGAGACCCGGCGCGAGTTCGCCGCGCAGAAGCCCCTCAAGGGCGCGCGTATCGCCGGCTGCCTGC
ACATGACCATCCAGACTGCGGTCCTCATCGAGACCCTGCAGGAGCTGGGCGCAGAGGTCCGCTGGTCCTCCTGCAACATC
TTCTCCACGCAGGACCAGGCAGCCGCCGCCGTCGCGGCTAACGGCACCCCGGTCTTCGCCTGGAAGGGCGAGACCGAGGA
GGAGTACTGGTGGTGCATCGAGCAGACCATCAACGGTCCGGACGGCTGGAAGCCGAACATGCTGCTCGACGACGGTGGTG
ACCTGACCGCCGTGATCCACGAGCAGTACCCGGACATGATGAAGGACATCTACGGTGTCTCCGAGGAGACCACCACCGGC
GTGCACCGTCTCTACGAGATGAGCCGTAAGGGCGAGCTCGGCATGCCGGCGTTCAACGTCAACGACTCGGTCACCAAGTC
GAAGTTCGACAACCTCTACGGCTGCCGTGAGTCGCTGGTCGACAGCATCAAGCGCGCCACCGACGTCATGATCGCCGGCA
AGGTGGCCGTCGTGGCCGGCTTCGGCGACGTCGGCAAGGGCTCGGCCCAGTCCCTGCGTGGCCTGGGTGCCCAGGTGTGG
GTCACCGAGGTCGACCCGATCTGTGCCCTGCAGGCCTCCATGGACGGCTACAAGGTCGTCACCATGGAAGAGGCTGCCCC
GGTGGCCGACATCTTCGTCACCGCCACGGGCAACTACAACGTGATCACCCACGATCACATGAAGGCGATGAAGGACGAGG
CCATCGTCTGCAACATCGGCCACTTCGACAACGAGATCGACGTGGCGAGCCTTAAGCAGTACAAGTGGGACGAGATCAAG
CCGCAGGTCGACCATGTCGAGTTCCCCGACGGCAAGAAGATCACCCTGCTCGCCGAGGGCCGCCTGGTGAACCTGGGCTG
CGCCACCGGCCACCCGTCCTTCGTGATGTCCAACTCGTTCACCAACCAGGTGATGGCTCAGATGGAGCTGTACAACAACC
CTGGCAAGTACGAGAAGGACGTCTACGTGCTGCCCAAGCACCTGGACGAGAAGGTTGCGGCGCTGCACCTCGGCCGCGTC
GGCGCCAACCTGACCCGTCTCAGCGAGGAGCAGGCCGGGTACATCGGCGTCTCCGTCGACGGGCCGTTCAAGCCGGAGTG
GTACCGCTACTAA

Upstream 100 bases:

>100_bases
GAGGACATCGACGTGCCGTGGGAGCGCACCGACCGTGCTGCCGCCCTCAAGGACGCCGCTGGCCTCAAGTAACCGAATAC
GCAAGGAGTAACCCGAAAGC

Downstream 100 bases:

>100_bases
GCCGGTACGCCACCACGGCTTGACCGACAGACCCGGGGGCCGCGCAGCGGCCTCCGGGGTTTCGGTTGAGCGCCCAGAGC
GTTCAGCGTTCAGCGTTCGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTAVLIETLQELGAEVRWSSCNI
FSTQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGPDGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTG
VHRLYEMSRKGELGMPAFNVNDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVW
VTEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIGHFDNEIDVASLKQYKWDEIK
PQVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSFTNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRV
GANLTRLSEEQAGYIGVSVDGPFKPEWYRY

Sequences:

>Translated_430_residues
MSNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTAVLIETLQELGAEVRWSSCNI
FSTQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGPDGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTG
VHRLYEMSRKGELGMPAFNVNDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVW
VTEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIGHFDNEIDVASLKQYKWDEIK
PQVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSFTNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRV
GANLTRLSEEQAGYIGVSVDGPFKPEWYRY
>Mature_429_residues
SNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTAVLIETLQELGAEVRWSSCNIF
STQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGPDGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTGV
HRLYEMSRKGELGMPAFNVNDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVWV
TEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIGHFDNEIDVASLKQYKWDEIKP
QVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSFTNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRVG
ANLTRLSEEQAGYIGVSVDGPFKPEWYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=427, Percent_Identity=67.9156908665105, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI239937451, Length=405, Percent_Identity=67.6543209876543, Blast_Score=553, Evalue=1e-158,
Organism=Homo sapiens, GI298286489, Length=431, Percent_Identity=56.1484918793503, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI24308043, Length=431, Percent_Identity=56.1484918793503, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI195539337, Length=431, Percent_Identity=56.1484918793503, Blast_Score=530, Evalue=1e-151,
Organism=Homo sapiens, GI195539349, Length=431, Percent_Identity=56.1484918793503, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI21361647, Length=431, Percent_Identity=54.9883990719258, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17506425, Length=434, Percent_Identity=66.5898617511521, Blast_Score=589, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6320882, Length=444, Percent_Identity=63.5135135135135, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24642172, Length=432, Percent_Identity=68.5185185185185, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24656245, Length=418, Percent_Identity=57.177033492823, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45553387, Length=428, Percent_Identity=56.0747663551402, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45553385, Length=427, Percent_Identity=55.9718969555035, Blast_Score=503, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_HALHL (A1WXM7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003241.1
- ProteinModelPortal:   A1WXM7
- SMR:   A1WXM7
- STRING:   A1WXM7
- GeneID:   4709919
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1675
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   A1WXM7
- ProtClustDB:   PRK05476
- BioCyc:   HHAL349124:HHAL_1675-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 47510; Mature: 47379

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 56-56 BINDING 131-131 BINDING 156-156 BINDING 186-186 BINDING 190-190 BINDING 191-191 BINDING 243-243 BINDING 278-278 BINDING 344-344

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTA
CCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLIETLQELGAEVRWSSCNIFSTQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGP
HHHHHHHHHCCCEEECCCCEECCCCCHHEEEECCCCEEEEECCCCCCHHEEEEEHHCCCC
DGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTGVHRLYEMSRKGELGMPAFNV
CCCCCCEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEECC
NDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHCCCCEEE
VTEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIG
EEECCCEEEEEECCCCEEEEEECCCCCEEEEEEEECCCEEEEEHHHHHHHCCCEEEEECC
HFDNEIDVASLKQYKWDEIKPQVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSF
CCCCCCCHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCH
TNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRVGANLTRLSEEQAGYIGVSVD
HHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEC
GPFKPEWYRY
CCCCCCCCCC
>Mature Secondary Structure 
SNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTA
CCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLIETLQELGAEVRWSSCNIFSTQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGP
HHHHHHHHHCCCEEECCCCEECCCCCHHEEEECCCCEEEEECCCCCCHHEEEEEHHCCCC
DGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTGVHRLYEMSRKGELGMPAFNV
CCCCCCEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEECC
NDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHCCCCEEE
VTEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIG
EEECCCEEEEEECCCCEEEEEECCCCCEEEEEEEECCCEEEEEHHHHHHHCCCEEEEECC
HFDNEIDVASLKQYKWDEIKPQVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSF
CCCCCCCHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCH
TNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRVGANLTRLSEEQAGYIGVSVD
HHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEC
GPFKPEWYRY
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA