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The map label for this gene is ilvB [H]

Identifier: 121998373

GI number: 121998373

Start: 1732693

End: 1734579

Strand: Reverse

Name: ilvB [H]

Synonym: Hhal_1594

Alternate gene names: 121998373

Gene position: 1734579-1732693 (Counterclockwise)

Preceding gene: 121998374

Following gene: 121998372

Centisome position: 64.76

GC content: 65.82

Gene sequence:

>1887_bases
ATGGATACCGCAATCGTTAACCCCCAGGCAGAGACTGAAGCAACCAGCCACCCGCTTGCCGGCAAGACCATGAGTGGCGG
GGAGATTATTGTCGAGGTCCTGGCCCAGGAGGGGGTCGATACGCTCTTTGGCTATAGCGGCGGTGCCATCCTTCCTACCT
ACGACGCCATCTTCAAGTACAACGAGCGTCACCGGAAAGAGCAGGCCGTCGAGGAAGAGGATCCGATCCGGCTGATCGTG
CCGGCCAACGAGCAGGGCGCCGGATTCATGGCAGCCGGCTACGCCCGGGCCACCGGCAAGGTCGGCTGCTTCCTGGTGAC
CTCCGGGCCGGGGGCGACCAACACGGTCACCCCCATCCGCGACTGCATGGCCGATTCGGTGCCGGTGGTGGCCATCACGG
GGCAGGTGCCGACGCACGCCATGGGCACGGATGCGTTCCAAGAGGCGCCCATCGTCAACATCATGGGGAGCTGCGCCAAG
CACGTCTTCCTGGTGACCGATCCGGAGCAGCTTGAGGCGACCGTGCGGACGGCCTTCGAGGTGGCTCGTTCCGGGCGTCC
GGGCCCCGTGGTGGTCGACGTGCCCAAGAACATGCAGAACTGGATCGGGGAGTTCCGCGGCGAGGGGGTGCTGGAGGTGC
GCGGCTATCGCCAGCGCATGGAATCCCTCCGCTCCGCCAAGCTCTCCGATCGCAAATGCCGGGCGTTCATGGAGATGCTC
GAGCGCTCCCGCCGGCCTCTGCTCTACGTCGGCGGCGGCGTGGTCAGTGGCGAGGCCCACCAGGAGTTGCGCGACTTCGC
CCACACCTTCGGGATCCCCGTGGTCAGTACCCTGATGGGCCTGGGGGCGGTGGATACGACCGATGACCTTTACCTGGGCA
TGCTCGGTATGCACGGCACGGCCTACGCCAACTACGCCGTGGAGGACTGTGATTTCCTCATCGCGGTCGGTGCCCGTTTC
GATGACCGGGTCGCCGGTAAGGTGGAGGAGTTCGCGCCGCTGGCCGAGCAGATCGCCCACATCGACATCGATGCTGCTGA
GATCGGCAAGGTCAAGGGCGTCGACTGGGCGCATGTCGGCGAGGCCGGGCGCAGCCTGCGCCAGCTGTTGCGCTACGGCG
AATCCATGGGCTTCGAGCCCCGCTTCGATGCCTGGCTTGAGCACGTGCGCGGGCTGCGTGAGCGCCACCCCATGGATTAC
GACCGCGACAGCGCGCTGATCCAGCCCCACTACGTGCTCGAAAAACTCAACGAACTGACTGCCGGCGAGGCGATCATTGC
CACCGGCGTCGGGCAGCACCAGATGTGGGCGGCACAGTACTGCGACTTCCGCGGTCCGCGGCAGTGGCTCACCTCCGGCG
GACTCGGCACCATGGGCTTCGGGCTGCCAGCGGCCATCGGCGCCTACCTGGGGCGTCCGGACCGGGTGGTCATCGACGTC
GATGGCGACGGTTCGCTGCGAATGAACCTCGGTGAGCTAGAGACAGCCACAACCTACAACCTGCCGGTCAAGATCCTGTC
GCTGAACAACGTCGGCGACGGCATGGTCCGGCAGTGGCAGAAGCTCTACTTCGGGGATCGCTTCTCCGGGTCGGACAAGT
CACTGCACCGCAAGGACTTCATCAAGGCGGCCGAGGCCGATGGCTACGAATTTGCCCGCCGCGTCGCGGACAAGGAGGAA
CTCGAGGAGGCCCTGCGCGCGTTTGTCGAGTTCCCTGGGCCCGCCTTCCTGGAGGTTATGATCGATCCGGATGCGGGGGT
CTTCCCGATGGTCGGTCCGGGCAGCAGCTACAAGGAGATGGTCACCGGCGATCACATCCCGAGCCGGGATATGGCCCTGC
GCCCGCGTACCAAGCTCGAGGACGGCGAGTCGCCGGATCTGTTCTGA

Upstream 100 bases:

>100_bases
AGGTCCGCCGGTGTGCGTTCCCCGCGGCGGTCGCGTCGGGCGGCGCGTCCGCCCCGCAGTGTTCGTGGAGCAATCGAGAG
GCCGAAGAGCCGTGAGGAAA

Downstream 100 bases:

>100_bases
GCAGCCGTCCGGGGTCGGGTCTGTGGGCGGCGATTCGGCGCCGCACGGGGTAGCGCGGCTGGCCGGTGTCTTCCTGGGGG
TGTCCCTGGACGGCGAGGGG

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MDTAIVNPQAETEATSHPLAGKTMSGGEIIVEVLAQEGVDTLFGYSGGAILPTYDAIFKYNERHRKEQAVEEEDPIRLIV
PANEQGAGFMAAGYARATGKVGCFLVTSGPGATNTVTPIRDCMADSVPVVAITGQVPTHAMGTDAFQEAPIVNIMGSCAK
HVFLVTDPEQLEATVRTAFEVARSGRPGPVVVDVPKNMQNWIGEFRGEGVLEVRGYRQRMESLRSAKLSDRKCRAFMEML
ERSRRPLLYVGGGVVSGEAHQELRDFAHTFGIPVVSTLMGLGAVDTTDDLYLGMLGMHGTAYANYAVEDCDFLIAVGARF
DDRVAGKVEEFAPLAEQIAHIDIDAAEIGKVKGVDWAHVGEAGRSLRQLLRYGESMGFEPRFDAWLEHVRGLRERHPMDY
DRDSALIQPHYVLEKLNELTAGEAIIATGVGQHQMWAAQYCDFRGPRQWLTSGGLGTMGFGLPAAIGAYLGRPDRVVIDV
DGDGSLRMNLGELETATTYNLPVKILSLNNVGDGMVRQWQKLYFGDRFSGSDKSLHRKDFIKAAEADGYEFARRVADKEE
LEEALRAFVEFPGPAFLEVMIDPDAGVFPMVGPGSSYKEMVTGDHIPSRDMALRPRTKLEDGESPDLF

Sequences:

>Translated_628_residues
MDTAIVNPQAETEATSHPLAGKTMSGGEIIVEVLAQEGVDTLFGYSGGAILPTYDAIFKYNERHRKEQAVEEEDPIRLIV
PANEQGAGFMAAGYARATGKVGCFLVTSGPGATNTVTPIRDCMADSVPVVAITGQVPTHAMGTDAFQEAPIVNIMGSCAK
HVFLVTDPEQLEATVRTAFEVARSGRPGPVVVDVPKNMQNWIGEFRGEGVLEVRGYRQRMESLRSAKLSDRKCRAFMEML
ERSRRPLLYVGGGVVSGEAHQELRDFAHTFGIPVVSTLMGLGAVDTTDDLYLGMLGMHGTAYANYAVEDCDFLIAVGARF
DDRVAGKVEEFAPLAEQIAHIDIDAAEIGKVKGVDWAHVGEAGRSLRQLLRYGESMGFEPRFDAWLEHVRGLRERHPMDY
DRDSALIQPHYVLEKLNELTAGEAIIATGVGQHQMWAAQYCDFRGPRQWLTSGGLGTMGFGLPAAIGAYLGRPDRVVIDV
DGDGSLRMNLGELETATTYNLPVKILSLNNVGDGMVRQWQKLYFGDRFSGSDKSLHRKDFIKAAEADGYEFARRVADKEE
LEEALRAFVEFPGPAFLEVMIDPDAGVFPMVGPGSSYKEMVTGDHIPSRDMALRPRTKLEDGESPDLF
>Mature_628_residues
MDTAIVNPQAETEATSHPLAGKTMSGGEIIVEVLAQEGVDTLFGYSGGAILPTYDAIFKYNERHRKEQAVEEEDPIRLIV
PANEQGAGFMAAGYARATGKVGCFLVTSGPGATNTVTPIRDCMADSVPVVAITGQVPTHAMGTDAFQEAPIVNIMGSCAK
HVFLVTDPEQLEATVRTAFEVARSGRPGPVVVDVPKNMQNWIGEFRGEGVLEVRGYRQRMESLRSAKLSDRKCRAFMEML
ERSRRPLLYVGGGVVSGEAHQELRDFAHTFGIPVVSTLMGLGAVDTTDDLYLGMLGMHGTAYANYAVEDCDFLIAVGARF
DDRVAGKVEEFAPLAEQIAHIDIDAAEIGKVKGVDWAHVGEAGRSLRQLLRYGESMGFEPRFDAWLEHVRGLRERHPMDY
DRDSALIQPHYVLEKLNELTAGEAIIATGVGQHQMWAAQYCDFRGPRQWLTSGGLGTMGFGLPAAIGAYLGRPDRVVIDV
DGDGSLRMNLGELETATTYNLPVKILSLNNVGDGMVRQWQKLYFGDRFSGSDKSLHRKDFIKAAEADGYEFARRVADKEE
LEEALRAFVEFPGPAFLEVMIDPDAGVFPMVGPGSSYKEMVTGDHIPSRDMALRPRTKLEDGESPDLF

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=560, Percent_Identity=25.3571428571429, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI93004078, Length=600, Percent_Identity=24.1666666666667, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1790104, Length=585, Percent_Identity=40.3418803418803, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI87081685, Length=586, Percent_Identity=39.9317406143345, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1786717, Length=567, Percent_Identity=30.1587301587302, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1787096, Length=494, Percent_Identity=28.5425101214575, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1788716, Length=585, Percent_Identity=27.008547008547, Blast_Score=132, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17542570, Length=523, Percent_Identity=23.3269598470363, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=593, Percent_Identity=25.4637436762226, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17531301, Length=593, Percent_Identity=25.4637436762226, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=606, Percent_Identity=42.7392739273927, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320816, Length=506, Percent_Identity=22.1343873517787, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323073, Length=553, Percent_Identity=22.2423146473779, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922626, Length=509, Percent_Identity=25.5402750491159, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 68660; Mature: 68660

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAIVNPQAETEATSHPLAGKTMSGGEIIVEVLAQEGVDTLFGYSGGAILPTYDAIFKY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHH
NERHRKEQAVEEEDPIRLIVPANEQGAGFMAAGYARATGKVGCFLVTSGPGATNTVTPIR
HHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCHHCCCCEEEEEEECCCCCCCCCHHHH
DCMADSVPVVAITGQVPTHAMGTDAFQEAPIVNIMGSCAKHVFLVTDPEQLEATVRTAFE
HHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHEEEEEECHHHHHHHHHHHHH
VARSGRPGPVVVDVPKNMQNWIGEFRGEGVLEVRGYRQRMESLRSAKLSDRKCRAFMEML
HHHCCCCCCEEEECCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERSRRPLLYVGGGVVSGEAHQELRDFAHTFGIPVVSTLMGLGAVDTTDDLYLGMLGMHGT
HHCCCCEEEECCEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHCCCCC
AYANYAVEDCDFLIAVGARFDDRVAGKVEEFAPLAEQIAHIDIDAAEIGKVKGVDWAHVG
HHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
EAGRSLRQLLRYGESMGFEPRFDAWLEHVRGLRERHPMDYDRDSALIQPHYVLEKLNELT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHH
AGEAIIATGVGQHQMWAAQYCDFRGPRQWLTSGGLGTMGFGLPAAIGAYLGRPDRVVIDV
CCCEEEEECCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
DGDGSLRMNLGELETATTYNLPVKILSLNNVGDGMVRQWQKLYFGDRFSGSDKSLHRKDF
CCCCCEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
IKAAEADGYEFARRVADKEELEEALRAFVEFPGPAFLEVMIDPDAGVFPMVGPGSSYKEM
HHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
VTGDHIPSRDMALRPRTKLEDGESPDLF
HCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTAIVNPQAETEATSHPLAGKTMSGGEIIVEVLAQEGVDTLFGYSGGAILPTYDAIFKY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHH
NERHRKEQAVEEEDPIRLIVPANEQGAGFMAAGYARATGKVGCFLVTSGPGATNTVTPIR
HHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCHHCCCCEEEEEEECCCCCCCCCHHHH
DCMADSVPVVAITGQVPTHAMGTDAFQEAPIVNIMGSCAKHVFLVTDPEQLEATVRTAFE
HHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHEEEEEECHHHHHHHHHHHHH
VARSGRPGPVVVDVPKNMQNWIGEFRGEGVLEVRGYRQRMESLRSAKLSDRKCRAFMEML
HHHCCCCCCEEEECCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERSRRPLLYVGGGVVSGEAHQELRDFAHTFGIPVVSTLMGLGAVDTTDDLYLGMLGMHGT
HHCCCCEEEECCEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHCCCCC
AYANYAVEDCDFLIAVGARFDDRVAGKVEEFAPLAEQIAHIDIDAAEIGKVKGVDWAHVG
HHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
EAGRSLRQLLRYGESMGFEPRFDAWLEHVRGLRERHPMDYDRDSALIQPHYVLEKLNELT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHH
AGEAIIATGVGQHQMWAAQYCDFRGPRQWLTSGGLGTMGFGLPAAIGAYLGRPDRVVIDV
CCCEEEEECCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
DGDGSLRMNLGELETATTYNLPVKILSLNNVGDGMVRQWQKLYFGDRFSGSDKSLHRKDF
CCCCCEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
IKAAEADGYEFARRVADKEELEEALRAFVEFPGPAFLEVMIDPDAGVFPMVGPGSSYKEM
HHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
VTGDHIPSRDMALRPRTKLEDGESPDLF
HCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]