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The map label for this gene is frdA [H]

Identifier: 121998232

GI number: 121998232

Start: 1561800

End: 1563572

Strand: Reverse

Name: frdA [H]

Synonym: Hhal_1450

Alternate gene names: 121998232

Gene position: 1563572-1561800 (Counterclockwise)

Preceding gene: 121998233

Following gene: 121998231

Centisome position: 58.38

GC content: 69.71

Gene sequence:

>1773_bases
TTGGAGACGATAGAATCGATCGATTGCGACCTGGTTGTCGTTGGCGGGGGCGGTGCCGGGCTGCGCGCCGCCATCGCCGC
GGCGGAACAGGATCCCGGGCTGCGCATCGCCCTGGTCTCCAAGGTGGTGCCCATGCGCAGCCATACGGTGGCGGCGGAGG
GTGGGGCTGCCGGCGTGGCCCGCGAGGACGACAGTCTGGAGGGTCACTTCAACGACACCGTGGCCGGTGGCGACTGGCTC
TGCGATCAGGATGTGGTCGAGCGCTTCGTCGCCGAGTGCACCGCCGAGATGGTCCAGCTCGAGCAGTGGGGGTGCCCCTG
GAGTCGGCAGGAGGATGGCCGGGTCCACGTCCGGTTCTTCGGCGGCATGACGACCCAGCGCAGCTGGTATGCGGCCGATA
AGACCGGGTTCCATATGCTGCATACGCTCTTTCAGACCTCGCTGCGTTATCCGAGCATCCAGCGCTACGACGAGTACTTC
TGCTCCGACCTGCTGGTGGATGATGGCGAGGTCTGCGGGGTGCTGGCGCTGGAGATCGCCAGCGGACGGCCGGTGCGCTT
TGGCGCCCCGGCGGTGGTTCTAGCCACTGGCGGGGCCGGGCGGGTCTACGGGCAGAACACCAATGCCGGGATCGTGACCG
GCGAGGGCATGGCCATGGCGCACGCCCAAGGGGTTCCCCTGCGCGATATGGAGTTCGTGCAGTGGCATCCCACCACGCTG
CCGGGCAGCGGTATCCTGATCACCGAAGGGTGCCGCGGTGAGGGCGGTATCCTCACCAACTGCGATGGTCGTCGCTACCT
GCAGGATTACGGTCTCGGTCCGACCGAGCCTTGGCCACGCCCGAAGGCGATGGAGCTGGGCCCGCGGGATCGGCTCTCCC
AGGCCTTCTGGTACGAGGATCGCGCGGGTCGCACGGTCTCCACGCCCCAGGGCACGGTCGTGCAGCTCGATCTGCGCCAC
CTGGGCGAGGCGCGCATCCTGGAACGCCTGCCGATGATCACCGAAGTGGCTCGCCGCTATGCCGGGGTGGATCCGGTCCG
GGCCCCGATCCCGGTGCGTCCTGCGGTCCACTACACCATGGGGGGGATCCCCACGGACGCCGACGGCGCGGCCCCGCTTC
CGGGGTTGTTCGCGGCCGGAGAGTGCGCCAGCACCGGCATCCATGGCGCCAATCGCCTCGGGTCGAATTCGCTCGCCGAA
CTCCTGGTCTTCGGTCGGGCAGCCGGGCAGGCAGCCGCCCGGCGTGCCCGCACGGCAACACGGCGGCCCCATCGCGTGGT
GGAGCGGTTGGCCGCCGAGGCGTTGGCCCCACGGCTCGCGTTGCTGGACAACGACGGTGGCGAGCGGCTGGCCGTGCTGC
GCGCGGGACTCCACCAGGCCATGGAGCAGGGCGTCGGGATCTTCCGCAACGAGACGGGGCTGGAACAGGCCTGCCATGCC
CTCGCGGTGCTCCGCGAGCGCGCGGCCCGCGGGATTCGGCTGGACGACCGCAGCCGGCCGTTCAACACCGAGTGGCTGAC
AGCCATGGAGTTCCGTGACAGCCTTCAGGTCGCCGAGGCGATGGCCTGGTCGGCACGGGCGCGCAGGGAGTCCCGTGGCG
CCCATGTGCGCGATGACGCCCATACCGAGCGGGATGACGAACGCTTCCTGGTCCACACCCTTGCTTACCCGGGTGGTGAG
ACTGGGCCGGTGATCGATCACGCGCCGGTAACCATTACCCGTTCCGAGCCGCGGCGACGGGCCTATGGGGCCGAAGGGGA
GGGCCGGTCGTGA

Upstream 100 bases:

>100_bases
GATACGATGCTCGGCAAGGTGCAGATGGCGGCGCTGGACCTAGAGTGATTCGGCCCGTGGCGGGTGACAGCCGAGCGGGT
CCGGGAGCGCAGGAGGTGCG

Downstream 100 bases:

>100_bases
GCGAGTGGCAGCACATCACCCTCGAAGTGCAACGCTACCACCCGGAGCAGGATGCCGCCCCGCGCTGGCAGCGTTACACC
GTGCCGTATACGCCGGATAT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
METIESIDCDLVVVGGGGAGLRAAIAAAEQDPGLRIALVSKVVPMRSHTVAAEGGAAGVAREDDSLEGHFNDTVAGGDWL
CDQDVVERFVAECTAEMVQLEQWGCPWSRQEDGRVHVRFFGGMTTQRSWYAADKTGFHMLHTLFQTSLRYPSIQRYDEYF
CSDLLVDDGEVCGVLALEIASGRPVRFGAPAVVLATGGAGRVYGQNTNAGIVTGEGMAMAHAQGVPLRDMEFVQWHPTTL
PGSGILITEGCRGEGGILTNCDGRRYLQDYGLGPTEPWPRPKAMELGPRDRLSQAFWYEDRAGRTVSTPQGTVVQLDLRH
LGEARILERLPMITEVARRYAGVDPVRAPIPVRPAVHYTMGGIPTDADGAAPLPGLFAAGECASTGIHGANRLGSNSLAE
LLVFGRAAGQAAARRARTATRRPHRVVERLAAEALAPRLALLDNDGGERLAVLRAGLHQAMEQGVGIFRNETGLEQACHA
LAVLRERAARGIRLDDRSRPFNTEWLTAMEFRDSLQVAEAMAWSARARRESRGAHVRDDAHTERDDERFLVHTLAYPGGE
TGPVIDHAPVTITRSEPRRRAYGAEGEGRS

Sequences:

>Translated_590_residues
METIESIDCDLVVVGGGGAGLRAAIAAAEQDPGLRIALVSKVVPMRSHTVAAEGGAAGVAREDDSLEGHFNDTVAGGDWL
CDQDVVERFVAECTAEMVQLEQWGCPWSRQEDGRVHVRFFGGMTTQRSWYAADKTGFHMLHTLFQTSLRYPSIQRYDEYF
CSDLLVDDGEVCGVLALEIASGRPVRFGAPAVVLATGGAGRVYGQNTNAGIVTGEGMAMAHAQGVPLRDMEFVQWHPTTL
PGSGILITEGCRGEGGILTNCDGRRYLQDYGLGPTEPWPRPKAMELGPRDRLSQAFWYEDRAGRTVSTPQGTVVQLDLRH
LGEARILERLPMITEVARRYAGVDPVRAPIPVRPAVHYTMGGIPTDADGAAPLPGLFAAGECASTGIHGANRLGSNSLAE
LLVFGRAAGQAAARRARTATRRPHRVVERLAAEALAPRLALLDNDGGERLAVLRAGLHQAMEQGVGIFRNETGLEQACHA
LAVLRERAARGIRLDDRSRPFNTEWLTAMEFRDSLQVAEAMAWSARARRESRGAHVRDDAHTERDDERFLVHTLAYPGGE
TGPVIDHAPVTITRSEPRRRAYGAEGEGRS
>Mature_590_residues
METIESIDCDLVVVGGGGAGLRAAIAAAEQDPGLRIALVSKVVPMRSHTVAAEGGAAGVAREDDSLEGHFNDTVAGGDWL
CDQDVVERFVAECTAEMVQLEQWGCPWSRQEDGRVHVRFFGGMTTQRSWYAADKTGFHMLHTLFQTSLRYPSIQRYDEYF
CSDLLVDDGEVCGVLALEIASGRPVRFGAPAVVLATGGAGRVYGQNTNAGIVTGEGMAMAHAQGVPLRDMEFVQWHPTTL
PGSGILITEGCRGEGGILTNCDGRRYLQDYGLGPTEPWPRPKAMELGPRDRLSQAFWYEDRAGRTVSTPQGTVVQLDLRH
LGEARILERLPMITEVARRYAGVDPVRAPIPVRPAVHYTMGGIPTDADGAAPLPGLFAAGECASTGIHGANRLGSNSLAE
LLVFGRAAGQAAARRARTATRRPHRVVERLAAEALAPRLALLDNDGGERLAVLRAGLHQAMEQGVGIFRNETGLEQACHA
LAVLRERAARGIRLDDRSRPFNTEWLTAMEFRDSLQVAEAMAWSARARRESRGAHVRDDAHTERDDERFLVHTLAYPGGE
TGPVIDHAPVTITRSEPRRRAYGAEGEGRS

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=576, Percent_Identity=39.0625, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=59.8627787307033, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=42.0393559928444, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=33.3333333333333, Blast_Score=226, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17505833, Length=537, Percent_Identity=38.7337057728119, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17550100, Length=596, Percent_Identity=36.4093959731544, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71986328, Length=427, Percent_Identity=27.8688524590164, Blast_Score=111, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=586, Percent_Identity=39.2491467576792, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322416, Length=557, Percent_Identity=39.4973070017953, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI17137288, Length=538, Percent_Identity=40.5204460966543, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655642, Length=538, Percent_Identity=40.5204460966543, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655647, Length=538, Percent_Identity=40.5204460966543, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24663005, Length=581, Percent_Identity=35.8003442340792, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63920; Mature: 63920

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIESIDCDLVVVGGGGAGLRAAIAAAEQDPGLRIALVSKVVPMRSHTVAAEGGAAGVA
CCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEECCCCCCCC
REDDSLEGHFNDTVAGGDWLCDQDVVERFVAECTAEMVQLEQWGCPWSRQEDGRVHVRFF
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
GGMTTQRSWYAADKTGFHMLHTLFQTSLRYPSIQRYDEYFCSDLLVDDGEVCGVLALEIA
CCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
SGRPVRFGAPAVVLATGGAGRVYGQNTNAGIVTGEGMAMAHAQGVPLRDMEFVQWHPTTL
CCCCEEECCCEEEEEECCCCEEEECCCCCEEEECCCEEEHHCCCCCCCCCCEEEECCCCC
PGSGILITEGCRGEGGILTNCDGRRYLQDYGLGPTEPWPRPKAMELGPRDRLSQAFWYED
CCCCEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
RAGRTVSTPQGTVVQLDLRHLGEARILERLPMITEVARRYAGVDPVRAPIPVRPAVHYTM
CCCCEECCCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GGIPTDADGAAPLPGLFAAGECASTGIHGANRLGSNSLAELLVFGRAAGQAAARRARTAT
CCCCCCCCCCCCCCCHHCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
RRPHRVVERLAAEALAPRLALLDNDGGERLAVLRAGLHQAMEQGVGIFRNETGLEQACHA
CCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
LAVLRERAARGIRLDDRSRPFNTEWLTAMEFRDSLQVAEAMAWSARARRESRGAHVRDDA
HHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HTERDDERFLVHTLAYPGGETGPVIDHAPVTITRSEPRRRAYGAEGEGRS
CCCCCCCEEEEEEEECCCCCCCCEECCCCEEEECCCCHHHHCCCCCCCCC
>Mature Secondary Structure
METIESIDCDLVVVGGGGAGLRAAIAAAEQDPGLRIALVSKVVPMRSHTVAAEGGAAGVA
CCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHCCCCCCEEEECCCCCCCC
REDDSLEGHFNDTVAGGDWLCDQDVVERFVAECTAEMVQLEQWGCPWSRQEDGRVHVRFF
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
GGMTTQRSWYAADKTGFHMLHTLFQTSLRYPSIQRYDEYFCSDLLVDDGEVCGVLALEIA
CCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
SGRPVRFGAPAVVLATGGAGRVYGQNTNAGIVTGEGMAMAHAQGVPLRDMEFVQWHPTTL
CCCCEEECCCEEEEEECCCCEEEECCCCCEEEECCCEEEHHCCCCCCCCCCEEEECCCCC
PGSGILITEGCRGEGGILTNCDGRRYLQDYGLGPTEPWPRPKAMELGPRDRLSQAFWYED
CCCCEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
RAGRTVSTPQGTVVQLDLRHLGEARILERLPMITEVARRYAGVDPVRAPIPVRPAVHYTM
CCCCEECCCCCCEEEEEHHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GGIPTDADGAAPLPGLFAAGECASTGIHGANRLGSNSLAELLVFGRAAGQAAARRARTAT
CCCCCCCCCCCCCCCHHCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
RRPHRVVERLAAEALAPRLALLDNDGGERLAVLRAGLHQAMEQGVGIFRNETGLEQACHA
CCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
LAVLRERAARGIRLDDRSRPFNTEWLTAMEFRDSLQVAEAMAWSARARRESRGAHVRDDA
HHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HTERDDERFLVHTLAYPGGETGPVIDHAPVTITRSEPRRRAYGAEGEGRS
CCCCCCCEEEEEEEECCCCCCCCEECCCCEEEECCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7037404; 7610040; 9278503; 2668268; 1856194; 10535936; 10373108; 11850430 [H]