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The map label for this gene is cysG1

Identifier: 121998125

GI number: 121998125

Start: 1452741

End: 1454195

Strand: Reverse

Name: cysG1

Synonym: Hhal_1343

Alternate gene names: 121998125

Gene position: 1454195-1452741 (Counterclockwise)

Preceding gene: 121998126

Following gene: 121998124

Centisome position: 54.29

GC content: 71.75

Gene sequence:

>1455_bases
ATGCACCACTACCCGATCTTCCTCAAGCTCCACGGTTGCCGCTGCCTGGTTGTGGGCGGCGGCGAGGCGGCTGCGCGCAG
GGCCGGGGATCTGCTCCGGGCCGGCGCGCGGGTGGAGTTGATCGCGCCGGTCCTGGCGGCGCCCTGCGAGCAACTGCTGG
ATACCAGCCCCGGCGAGCTCCACCACCGCGCCGAGCCGTTCGCGGCGGGTATGGAGGAGGGCGCGGCGCTGGTGGTGGGG
GCCAGCGGCGATGAGGCCACCGACCGTACCGTCTATGAGGCGTGTCGTGCCCGGGGGATTCCCGTCAACGTTGCCGGCCG
GCCGTCGCTGAGCACCTACATCACCCCGGTCCAGGTGGATCGCTCGCCCCTGCAGCTGGCGGTCTCCAGCGGTGGCGCCG
CGCCGGTGCTGGCAAGGCAGATCGCCAGTCGGCTAGAGACACTGCTGCCGGCGGCCTACGGCCGGCTGGCACGCCTGGCC
GGACGGATGCGGGAGCAGGTGCGGGTGGCGCTGCCGGACAAGGACTGGCGGTTGCGGTTCTGGGAGCAGATCTTCGATGG
GGCGGCGGCGGAATCGGTGTTGGCAGGGCGCGAGGCCGAGGGGGAGGCCGAACTGCTGCGCCTGCTCGAGCAGGAACAGG
CCCGGCCGGCCCCGCAGGGGGAGGTCTTCCTGGTCGGCGCTGGCCCCGGGGACCCCGATCTACTGACCTTCCGTGCGCTG
CGCCTGATGCAGCGGGCTGACGTGGTGCTCTACGATCGTCTGGCGGCGCCGGCCCTGCTGGATCTGGTGCGCAAGGAGGC
CGAGCGGATCCCCGTGGGCAAGCGCCGCGGTCGGCATACACTGCCGCAGGAGCGGATCAACGAGCGGCTGGTGGAATTGG
CGCGTGCCGGTAAACGGGTCCTGCGTCTCAAGGGCGGTGACCCATTCCTCTTCGGCCGCGGCGGTGAGGAGATCGAGGGG
CTGATCGAGCAGGACATCCCCTTCCAGGTGGTGCCCGGCATCAGCGCCGCCCAGGGGGCGGCGAGCTATGCCGGTATCCC
GCTCACCCACCGGGATTACGCCCAGACCTGTCGCCTGCTCACCGGTCACCGGCGGGCCGGGCACCCGCAGATGAAGGCCC
ACGCGCCCTATCGCCAGGACGAGACACTCATCATCTACATGGGCCTGGTCAACCTCGAGGCGGTGTGCGAGCAACTGTGC
GAGTGTGGGCTGCCGCCCGAGCATCCGGCTGCGGTGGTGGCCCAGGCGACGACGCCGCAGCAGCGCGTGGTCCTCGGCAA
TCTGCGGACCCTGGCTGAACGGGTCCGCGCCGAACGGGTGGAGAGCCCGGCGCTGGTGGTGGTCGGTCCCACGGTGCAGT
TGCACCCGCGCCTGGGCTGGTACCGCGGCGAGGCGGAGGACCGCGATGCGGCGGCCAGCATCGACCCGTGCTGGACGGGC
GGCATGCGCGACTGA

Upstream 100 bases:

>100_bases
CCTCGAGCTGGTCGATGCCCGCGGCCGGGGGCTCTTGTCCCTGCAGCGGGTGACGGGGAAGAACCGACCCATGGACCCAT
CCGGGGGGTGAACTGAACCC

Downstream 100 bases:

>100_bases
TTCGGTCGATGGGCGATGAGTGACGAACGGGGAAGGACAGCGCTGCCCATCGATTCACTGCGGCCGGACTTCCACCGGGC
GCTGGAGCAGGGCCACTGCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MHHYPIFLKLHGCRCLVVGGGEAAARRAGDLLRAGARVELIAPVLAAPCEQLLDTSPGELHHRAEPFAAGMEEGAALVVG
ASGDEATDRTVYEACRARGIPVNVAGRPSLSTYITPVQVDRSPLQLAVSSGGAAPVLARQIASRLETLLPAAYGRLARLA
GRMREQVRVALPDKDWRLRFWEQIFDGAAAESVLAGREAEGEAELLRLLEQEQARPAPQGEVFLVGAGPGDPDLLTFRAL
RLMQRADVVLYDRLAAPALLDLVRKEAERIPVGKRRGRHTLPQERINERLVELARAGKRVLRLKGGDPFLFGRGGEEIEG
LIEQDIPFQVVPGISAAQGAASYAGIPLTHRDYAQTCRLLTGHRRAGHPQMKAHAPYRQDETLIIYMGLVNLEAVCEQLC
ECGLPPEHPAAVVAQATTPQQRVVLGNLRTLAERVRAERVESPALVVVGPTVQLHPRLGWYRGEAEDRDAAASIDPCWTG
GMRD

Sequences:

>Translated_484_residues
MHHYPIFLKLHGCRCLVVGGGEAAARRAGDLLRAGARVELIAPVLAAPCEQLLDTSPGELHHRAEPFAAGMEEGAALVVG
ASGDEATDRTVYEACRARGIPVNVAGRPSLSTYITPVQVDRSPLQLAVSSGGAAPVLARQIASRLETLLPAAYGRLARLA
GRMREQVRVALPDKDWRLRFWEQIFDGAAAESVLAGREAEGEAELLRLLEQEQARPAPQGEVFLVGAGPGDPDLLTFRAL
RLMQRADVVLYDRLAAPALLDLVRKEAERIPVGKRRGRHTLPQERINERLVELARAGKRVLRLKGGDPFLFGRGGEEIEG
LIEQDIPFQVVPGISAAQGAASYAGIPLTHRDYAQTCRLLTGHRRAGHPQMKAHAPYRQDETLIIYMGLVNLEAVCEQLC
ECGLPPEHPAAVVAQATTPQQRVVLGNLRTLAERVRAERVESPALVVVGPTVQLHPRLGWYRGEAEDRDAAASIDPCWTG
GMRD
>Mature_484_residues
MHHYPIFLKLHGCRCLVVGGGEAAARRAGDLLRAGARVELIAPVLAAPCEQLLDTSPGELHHRAEPFAAGMEEGAALVVG
ASGDEATDRTVYEACRARGIPVNVAGRPSLSTYITPVQVDRSPLQLAVSSGGAAPVLARQIASRLETLLPAAYGRLARLA
GRMREQVRVALPDKDWRLRFWEQIFDGAAAESVLAGREAEGEAELLRLLEQEQARPAPQGEVFLVGAGPGDPDLLTFRAL
RLMQRADVVLYDRLAAPALLDLVRKEAERIPVGKRRGRHTLPQERINERLVELARAGKRVLRLKGGDPFLFGRGGEEIEG
LIEQDIPFQVVPGISAAQGAASYAGIPLTHRDYAQTCRLLTGHRRAGHPQMKAHAPYRQDETLIIYMGLVNLEAVCEQLC
ECGLPPEHPAAVVAQATTPQQRVVLGNLRTLAERVRAERVESPALVVVGPTVQLHPRLGWYRGEAEDRDAAASIDPCWTG
GMRD

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family

Homologues:

Organism=Escherichia coli, GI1789768, Length=461, Percent_Identity=44.0347071583514, Blast_Score=367, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322922, Length=441, Percent_Identity=26.530612244898, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSG1_HALHL (A1WWP8)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002912.1
- ProteinModelPortal:   A1WWP8
- SMR:   A1WWP8
- STRING:   A1WWP8
- GeneID:   4710901
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1343
- eggNOG:   COG0007
- HOGENOM:   HBG730212
- OMA:   RHTLPQE
- PhylomeDB:   A1WWP8
- ProtClustDB:   CLSK733900
- BioCyc:   HHAL349124:HHAL_1343-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01646
- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043
- Gene3D:   G3DSA:3.40.1010.10
- Gene3D:   G3DSA:3.30.950.10
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.8.210
- TIGRFAMs:   TIGR01469
- TIGRFAMs:   TIGR01470

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase; SSF53790 Cor/por_Metransf

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4

Molecular weight: Translated: 52542; Mature: 52542

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00839 SUMT_1; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHYPIFLKLHGCRCLVVGGGEAAARRAGDLLRAGARVELIAPVLAAPCEQLLDTSPGEL
CCCCEEEEEEECEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHH
HHRAEPFAAGMEEGAALVVGASGDEATDRTVYEACRARGIPVNVAGRPSLSTYITPVQVD
HHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEECEEEEC
RSPLQLAVSSGGAAPVLARQIASRLETLLPAAYGRLARLAGRMREQVRVALPDKDWRLRF
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHH
WEQIFDGAAAESVLAGREAEGEAELLRLLEQEQARPAPQGEVFLVGAGPGDPDLLTFRAL
HHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
RLMQRADVVLYDRLAAPALLDLVRKEAERIPVGKRRGRHTLPQERINERLVELARAGKRV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
LRLKGGDPFLFGRGGEEIEGLIEQDIPFQVVPGISAAQGAASYAGIPLTHRDYAQTCRLL
EEEECCCEEEECCCCHHHHHHHHCCCCEEEECCCCHHCCCHHHCCCCCCCHHHHHHHHHH
TGHRRAGHPQMKAHAPYRQDETLIIYMGLVNLEAVCEQLCECGLPPEHPAAVVAQATTPQ
HCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCC
QRVVLGNLRTLAERVRAERVESPALVVVGPTVQLHPRLGWYRGEAEDRDAAASIDPCWTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCEECCCCCCCCCCCCCCCCCCC
GMRD
CCCC
>Mature Secondary Structure
MHHYPIFLKLHGCRCLVVGGGEAAARRAGDLLRAGARVELIAPVLAAPCEQLLDTSPGEL
CCCCEEEEEEECEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHH
HHRAEPFAAGMEEGAALVVGASGDEATDRTVYEACRARGIPVNVAGRPSLSTYITPVQVD
HHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEECEEEEC
RSPLQLAVSSGGAAPVLARQIASRLETLLPAAYGRLARLAGRMREQVRVALPDKDWRLRF
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHH
WEQIFDGAAAESVLAGREAEGEAELLRLLEQEQARPAPQGEVFLVGAGPGDPDLLTFRAL
HHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
RLMQRADVVLYDRLAAPALLDLVRKEAERIPVGKRRGRHTLPQERINERLVELARAGKRV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
LRLKGGDPFLFGRGGEEIEGLIEQDIPFQVVPGISAAQGAASYAGIPLTHRDYAQTCRLL
EEEECCCEEEECCCCHHHHHHHHCCCCEEEECCCCHHCCCHHHCCCCCCCHHHHHHHHHH
TGHRRAGHPQMKAHAPYRQDETLIIYMGLVNLEAVCEQLCECGLPPEHPAAVVAQATTPQ
HCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCC
QRVVLGNLRTLAERVRAERVESPALVVVGPTVQLHPRLGWYRGEAEDRDAAASIDPCWTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCEECCCCCCCCCCCCCCCCCCC
GMRD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA