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The map label for this gene is dnaA

Identifier: 121998017

GI number: 121998017

Start: 1333575

End: 1334924

Strand: Reverse

Name: dnaA

Synonym: Hhal_1227

Alternate gene names: 121998017

Gene position: 1334924-1333575 (Counterclockwise)

Preceding gene: 121998022

Following gene: 121998016

Centisome position: 49.84

GC content: 64.22

Gene sequence:

>1350_bases
ATGGACGACTCGCTCTGGAGCGCGTGCCTTCAGCAATTAGAGCGCGAGATCCCCGAGCAGCAGCTCAACACCTGGATTCG
TCCCCTGCAGGCGCACCTCGAGGGTGACGCCCTGCGCCTCTACGCACCGAACCGCTTCGTCCTCGACTGGGTGCGCGACA
ACTTCTCGGCCCGCATCGGCGAACTGCTCGCCGAAATCCGCCCCGATGAGCACCTGCGCGTAGAACTGGAGATCGGCTCG
CCCCCGACGCCCGACCAGCGCGAGGCCGCCACCGGCGCCACGCGCGCCGCCCCAGCGCAGCGCAGCTCCGAGCCCCGTCA
ACGCCCCGTGGACTCGAACCTGAATCCCGGGTTCACCTTCGACTCCTTCGTCGAGGGCAAGTCGAACCAGCTGGCCCGCG
CAGCCAGCATGCAGGTCGCCGACAACCCCGGCGGTGCCTACAACCCACTATTTCTCTACGGCGGTGTCGGACTGGGCAAG
ACCCACCTGATGCATGCCGTGGGCAACGCCATACGGACCGCCCGCCCGGAAGCACGTGTGCTTTACCTCCACTCCGAGCG
TTTCGTCGCCGAGATGGTCAAGGCGCTGCAACACAACGCCATCAACGAATTCAAGCGCCACTACCGCAACCTGGACGCGC
TGCTCATCGACGACATCCAGTTCTTTGCCGGCAAGGAGCGCTCGCAGGAGGAGTTCTTCCACACCTTCAACGCTCTGCTT
GAAAGCGAGCAGCAGGTGATCATGACCTGCGACCGCTACCCGAAGGAAGTCAACGGTCTGGAGGAGCGCCTTAAATCGCG
CTTCGGGTGGGGGCTGACTGTGGCCATCGAGCCGCCGGAGCTCGAGACCCGTGTTGCCATCCTCAAGAGCAAGGCCATCC
GCGACGGCGTCGACCTACCCGACGAGGTGGCCTTCTTCGTGGCCAAGCGTCTACGCTCCAACGTCCGTGAGCTCGAGGGC
GCCCTGCGGCGCATCACCGCCAACGCCCAGTTCACCGGTCGCGCCATTGATGTCGACTTTGCCAAGGAAGCCTTGCGGGA
TCTCTTGGCCCTGCAGGACAAGCTGGTCACCATCGACAACATCCAAAAGACCGTGGCCGCCTATTACAAGATCCGCGTCG
GCGATCTGCTCTCCAAGCGCCGCAGCCGTTCCATCACACGACCCCGCCACATGGCCATGGTCCTGGCCAAGGAGCTGACC
TCGCATTCGCTACCGGAGATCGGCGACGCCTTCGGCGGGCGCGACCACAGCACGGTTCTCCACGCCTGCCGCAACATCAA
GTCGCTGATCGAAGACGACGCGCGCCTCGCCGAAGATTACGACAACCTGTTGAGAACCTTGAGCACTTAG

Upstream 100 bases:

>100_bases
AAAACCTGTGGATAACCACCCCACCCCCCTTTAAACTATGCCGTCCACGATCCCCGGCCTCACCGGCCCCACCACCCGGA
ACAACGAGGTAGCCGTCACC

Downstream 100 bases:

>100_bases
CCCGGCGTAAGCTGTGGAAAACCTGCGGAGTGATCCAAGGGTGAATTCCATCCCCAGGTTTTCCACATACACCGCACCGC
CCGCCCTGGTGTTTGTTGTG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDDSLWSACLQQLEREIPEQQLNTWIRPLQAHLEGDALRLYAPNRFVLDWVRDNFSARIGELLAEIRPDEHLRVELEIGS
PPTPDQREAATGATRAAPAQRSSEPRQRPVDSNLNPGFTFDSFVEGKSNQLARAASMQVADNPGGAYNPLFLYGGVGLGK
THLMHAVGNAIRTARPEARVLYLHSERFVAEMVKALQHNAINEFKRHYRNLDALLIDDIQFFAGKERSQEEFFHTFNALL
ESEQQVIMTCDRYPKEVNGLEERLKSRFGWGLTVAIEPPELETRVAILKSKAIRDGVDLPDEVAFFVAKRLRSNVRELEG
ALRRITANAQFTGRAIDVDFAKEALRDLLALQDKLVTIDNIQKTVAAYYKIRVGDLLSKRRSRSITRPRHMAMVLAKELT
SHSLPEIGDAFGGRDHSTVLHACRNIKSLIEDDARLAEDYDNLLRTLST

Sequences:

>Translated_449_residues
MDDSLWSACLQQLEREIPEQQLNTWIRPLQAHLEGDALRLYAPNRFVLDWVRDNFSARIGELLAEIRPDEHLRVELEIGS
PPTPDQREAATGATRAAPAQRSSEPRQRPVDSNLNPGFTFDSFVEGKSNQLARAASMQVADNPGGAYNPLFLYGGVGLGK
THLMHAVGNAIRTARPEARVLYLHSERFVAEMVKALQHNAINEFKRHYRNLDALLIDDIQFFAGKERSQEEFFHTFNALL
ESEQQVIMTCDRYPKEVNGLEERLKSRFGWGLTVAIEPPELETRVAILKSKAIRDGVDLPDEVAFFVAKRLRSNVRELEG
ALRRITANAQFTGRAIDVDFAKEALRDLLALQDKLVTIDNIQKTVAAYYKIRVGDLLSKRRSRSITRPRHMAMVLAKELT
SHSLPEIGDAFGGRDHSTVLHACRNIKSLIEDDARLAEDYDNLLRTLST
>Mature_449_residues
MDDSLWSACLQQLEREIPEQQLNTWIRPLQAHLEGDALRLYAPNRFVLDWVRDNFSARIGELLAEIRPDEHLRVELEIGS
PPTPDQREAATGATRAAPAQRSSEPRQRPVDSNLNPGFTFDSFVEGKSNQLARAASMQVADNPGGAYNPLFLYGGVGLGK
THLMHAVGNAIRTARPEARVLYLHSERFVAEMVKALQHNAINEFKRHYRNLDALLIDDIQFFAGKERSQEEFFHTFNALL
ESEQQVIMTCDRYPKEVNGLEERLKSRFGWGLTVAIEPPELETRVAILKSKAIRDGVDLPDEVAFFVAKRLRSNVRELEG
ALRRITANAQFTGRAIDVDFAKEALRDLLALQDKLVTIDNIQKTVAAYYKIRVGDLLSKRRSRSITRPRHMAMVLAKELT
SHSLPEIGDAFGGRDHSTVLHACRNIKSLIEDDARLAEDYDNLLRTLST

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=467, Percent_Identity=66.3811563169165, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=232, Percent_Identity=28.8793103448276, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_HALHL (A1WWE0)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002804.1
- ProteinModelPortal:   A1WWE0
- STRING:   A1WWE0
- GeneID:   4710435
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1227
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   A1WWE0
- ProtClustDB:   PRK00149
- BioCyc:   HHAL349124:HHAL_1227-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50744; Mature: 50744

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDSLWSACLQQLEREIPEQQLNTWIRPLQAHLEGDALRLYAPNRFVLDWVRDNFSARIG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
ELLAEIRPDEHLRVELEIGSPPTPDQREAATGATRAAPAQRSSEPRQRPVDSNLNPGFTF
HHHHHCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DSFVEGKSNQLARAASMQVADNPGGAYNPLFLYGGVGLGKTHLMHAVGNAIRTARPEARV
HHHHCCCCHHHHHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
LYLHSERFVAEMVKALQHNAINEFKRHYRNLDALLIDDIQFFAGKERSQEEFFHTFNALL
EEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ESEQQVIMTCDRYPKEVNGLEERLKSRFGWGLTVAIEPPELETRVAILKSKAIRDGVDLP
HCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCH
DEVAFFVAKRLRSNVRELEGALRRITANAQFTGRAIDVDFAKEALRDLLALQDKLVTIDN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHH
IQKTVAAYYKIRVGDLLSKRRSRSITRPRHMAMVLAKELTSHSLPEIGDAFGGRDHSTVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHH
HACRNIKSLIEDDARLAEDYDNLLRTLST
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDSLWSACLQQLEREIPEQQLNTWIRPLQAHLEGDALRLYAPNRFVLDWVRDNFSARIG
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
ELLAEIRPDEHLRVELEIGSPPTPDQREAATGATRAAPAQRSSEPRQRPVDSNLNPGFTF
HHHHHCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DSFVEGKSNQLARAASMQVADNPGGAYNPLFLYGGVGLGKTHLMHAVGNAIRTARPEARV
HHHHCCCCHHHHHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
LYLHSERFVAEMVKALQHNAINEFKRHYRNLDALLIDDIQFFAGKERSQEEFFHTFNALL
EEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ESEQQVIMTCDRYPKEVNGLEERLKSRFGWGLTVAIEPPELETRVAILKSKAIRDGVDLP
HCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCH
DEVAFFVAKRLRSNVRELEGALRRITANAQFTGRAIDVDFAKEALRDLLALQDKLVTIDN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHH
IQKTVAAYYKIRVGDLLSKRRSRSITRPRHMAMVLAKELTSHSLPEIGDAFGGRDHSTVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHH
HACRNIKSLIEDDARLAEDYDNLLRTLST
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA