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The map label for this gene is hisB

Identifier: 121997885

GI number: 121997885

Start: 1187112

End: 1187705

Strand: Reverse

Name: hisB

Synonym: Hhal_1094

Alternate gene names: 121997885

Gene position: 1187705-1187112 (Counterclockwise)

Preceding gene: 121997886

Following gene: 121997884

Centisome position: 44.34

GC content: 69.02

Gene sequence:

>594_bases
ATGGCCAAGCGAACGGCAGAAGTCGAGCGCACCACCGGCGAGACCGCTGTGCGGGTGTGGGTGGATCTCGACGGCGAGGG
GGCGGCGGAACTCGATTGTGGGGTCCCGTTCTTTGAGCACATGCTCGCTCAGGTGGCCCGCCACGGTGGCGTGGACCTGC
GCGTTCAGGCCAAGGGGGACACCTGGATCGACGACCACCACACCGTCGAGGATGTCGGCATCGCCCTGGGGCAGGCGCTG
GCCCGGGCGTGGGGTGATAAGGCCGGTCTGACCCGCTACGGCCACGCCTACGTGCCGCTGGATGAGGCCCTGTCGCGCGC
GGTCCTCGACCTCTCGGGGCGGCCCGGACTGGTCTACAACGCCGAGCTGCCGCGGGCGCACGTCGGGCGATTCGATACCG
AGCTGGTGGAGGAGTTCTTCCGTGCCCTGACCAGCCACGCCGCCATGACCGCCCACCTGGATGTGCTGCGCGGCCGCAAT
GCCCATCACATGGTCGAGTGTCTGTTCAAGGCCTTCGGGCGTGCCCTGCGCCAGGCCGTTAGCACGGATGAGCGTGCCGG
TGGTCGGGTTCCTTCCACCAAGGGGGCCCTCTAG

Upstream 100 bases:

>100_bases
CTGGAAGCGCCGCCGAGGCCCGCTGGCCCCGTGTGATATCCTCGGTCGCCCGTCGGGCGGAAGGCCCGTCAACGATTCCA
ACTGCGAGGGCGTCACGGCC

Downstream 100 bases:

>100_bases
CCATGAGTCGCGTGGCCATTGTCGATTACGGGATGGGCAACCTGCGCTCGGTCTATCGCGCCCTGGCCCACGCCGCCGGC
GGCGAGTCGGGCCTCGAGGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MAKRTAEVERTTGETAVRVWVDLDGEGAAELDCGVPFFEHMLAQVARHGGVDLRVQAKGDTWIDDHHTVEDVGIALGQAL
ARAWGDKAGLTRYGHAYVPLDEALSRAVLDLSGRPGLVYNAELPRAHVGRFDTELVEEFFRALTSHAAMTAHLDVLRGRN
AHHMVECLFKAFGRALRQAVSTDERAGGRVPSTKGAL

Sequences:

>Translated_197_residues
MAKRTAEVERTTGETAVRVWVDLDGEGAAELDCGVPFFEHMLAQVARHGGVDLRVQAKGDTWIDDHHTVEDVGIALGQAL
ARAWGDKAGLTRYGHAYVPLDEALSRAVLDLSGRPGLVYNAELPRAHVGRFDTELVEEFFRALTSHAAMTAHLDVLRGRN
AHHMVECLFKAFGRALRQAVSTDERAGGRVPSTKGAL
>Mature_196_residues
AKRTAEVERTTGETAVRVWVDLDGEGAAELDCGVPFFEHMLAQVARHGGVDLRVQAKGDTWIDDHHTVEDVGIALGQALA
RAWGDKAGLTRYGHAYVPLDEALSRAVLDLSGRPGLVYNAELPRAHVGRFDTELVEEFFRALTSHAAMTAHLDVLRGRNA
HHMVECLFKAFGRALRQAVSTDERAGGRVPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=51.5463917525773, Blast_Score=195, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=40.2714932126697, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_HALHL (A1WW08)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002672.1
- ProteinModelPortal:   A1WW08
- SMR:   A1WW08
- STRING:   A1WW08
- GeneID:   4709930
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1094
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A1WW08
- BioCyc:   HHAL349124:HHAL_1094-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21449; Mature: 21318

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRTAEVERTTGETAVRVWVDLDGEGAAELDCGVPFFEHMLAQVARHGGVDLRVQAKGD
CCCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
TWIDDHHTVEDVGIALGQALARAWGDKAGLTRYGHAYVPLDEALSRAVLDLSGRPGLVYN
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEEE
AELPRAHVGRFDTELVEEFFRALTSHAAMTAHLDVLRGRNAHHMVECLFKAFGRALRQAV
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
STDERAGGRVPSTKGAL
CCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKRTAEVERTTGETAVRVWVDLDGEGAAELDCGVPFFEHMLAQVARHGGVDLRVQAKGD
CCCCCHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
TWIDDHHTVEDVGIALGQALARAWGDKAGLTRYGHAYVPLDEALSRAVLDLSGRPGLVYN
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCEEEE
AELPRAHVGRFDTELVEEFFRALTSHAAMTAHLDVLRGRNAHHMVECLFKAFGRALRQAV
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
STDERAGGRVPSTKGAL
CCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA