Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 121997830

GI number: 121997830

Start: 1121786

End: 1122850

Strand: Reverse

Name: fba [H]

Synonym: Hhal_1039

Alternate gene names: 121997830

Gene position: 1122850-1121786 (Counterclockwise)

Preceding gene: 121997831

Following gene: 121997829

Centisome position: 41.92

GC content: 67.23

Gene sequence:

>1065_bases
ATGGCGATGATCACCCTGCGACAGCTGCTCGATCACGCAGCCGAGCACGGCTACGGCATGCCGGCGTTCAACGCCAACAA
CATGGAGCAGTTGCACGCCATCATGGAGGCGGCCAAGGAGTGCGACAGCCCGGCCATCGTCCAGGCGTCCGCCGGTGCCC
GCAAGTATGCCGGTGTCCCCTTCTATCGGCACCTGATGGAGGCCGCCGTGGAGTCCTACCCGGACGTGCCGCTGGTGGTC
CACCTCGACCACGGTGCCAATCCCGGTGCCTGCATGCGCGCCATCCAGTCCGGGTTCACCTCGGTGATGATGGACGGCTC
CCTGAAGGAAGACGGCAAGACCCCGGCCGACTACGACTACAACGCCAGCGTGACCCGGCGCGCCGCCGAGATGGCCCACG
CCGGCGGTGTCTCCGTCGAGGGCGAGATCGGTGTGCTCGGCTCCCTAGAGACGGGTGAGGCCGGCAAGGAGGACGGCGTC
GGCGCTGAGGGCAAGATGGACAAGGACAAGCTCCTCACCGATCCCGAGGAGGCGGCCCAGTTCGTCCGCGATACCCACGT
CGACGCCCTCGCCATCGCCTGCGGCACCAGCCACGGTGCCTACAAGTTCACCCGCCCGCCGACGGGCGACATCCTGGCCA
TCAGCCGGATCAAGGAGATCCACCAGCGTCTGCCGGACACCCACCTGGTGATGCACGGCAGCTCCCAGGTGCCGCAGGAG
TGGCTGGAGCTGATCAACCGCTTCGGCGGCGAGATCCCCGAGACCTACGGCGTGCCGGTCGAGGAGGTCCAGGAGGGCAT
CCGCAACGGCGTGCGTAAGGTCAACATCGACACGGACCTGCGCCTGGCCTCCACCGGTGCGGTGCGCAAGCACCTGGCCG
AGAACCCGTCGAACTTCGACCCGCGTAAGTTCCTGAAGGCCTCCACCGAGGCCATGAAGGAGATCTGCAAGGCCCGCTAC
GAGGCCTTCGGTTCGGCGGGCATGGCCTCCAAGATCAAGCCGATCGCGCTGGAGACCATGGTCGAGCGCTACGAGTCCGG
CGAGCTCGCCCCCAAGGTGAGCTGA

Upstream 100 bases:

>100_bases
CGAGGAGCTCGGCGCCGCAGGGGGCACGAACACGTTGCGCATCGTCTGCGTGGACGATTATCTCTAGAGTGAATGCATAG
ATAGCGGAGGAGTCGAAACT

Downstream 100 bases:

>100_bases
GCCCGGAGCGGTCCCCAGTGCCTGGCCGGGGCGCCCTCGCGCCCCGGCGGGTGGGCGGGGAGGATCATCATGCGCAGGAT
TGGCGGGATATTCCTCAAGG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAMITLRQLLDHAAEHGYGMPAFNANNMEQLHAIMEAAKECDSPAIVQASAGARKYAGVPFYRHLMEAAVESYPDVPLVV
HLDHGANPGACMRAIQSGFTSVMMDGSLKEDGKTPADYDYNASVTRRAAEMAHAGGVSVEGEIGVLGSLETGEAGKEDGV
GAEGKMDKDKLLTDPEEAAQFVRDTHVDALAIACGTSHGAYKFTRPPTGDILAISRIKEIHQRLPDTHLVMHGSSQVPQE
WLELINRFGGEIPETYGVPVEEVQEGIRNGVRKVNIDTDLRLASTGAVRKHLAENPSNFDPRKFLKASTEAMKEICKARY
EAFGSAGMASKIKPIALETMVERYESGELAPKVS

Sequences:

>Translated_354_residues
MAMITLRQLLDHAAEHGYGMPAFNANNMEQLHAIMEAAKECDSPAIVQASAGARKYAGVPFYRHLMEAAVESYPDVPLVV
HLDHGANPGACMRAIQSGFTSVMMDGSLKEDGKTPADYDYNASVTRRAAEMAHAGGVSVEGEIGVLGSLETGEAGKEDGV
GAEGKMDKDKLLTDPEEAAQFVRDTHVDALAIACGTSHGAYKFTRPPTGDILAISRIKEIHQRLPDTHLVMHGSSQVPQE
WLELINRFGGEIPETYGVPVEEVQEGIRNGVRKVNIDTDLRLASTGAVRKHLAENPSNFDPRKFLKASTEAMKEICKARY
EAFGSAGMASKIKPIALETMVERYESGELAPKVS
>Mature_353_residues
AMITLRQLLDHAAEHGYGMPAFNANNMEQLHAIMEAAKECDSPAIVQASAGARKYAGVPFYRHLMEAAVESYPDVPLVVH
LDHGANPGACMRAIQSGFTSVMMDGSLKEDGKTPADYDYNASVTRRAAEMAHAGGVSVEGEIGVLGSLETGEAGKEDGVG
AEGKMDKDKLLTDPEEAAQFVRDTHVDALAIACGTSHGAYKFTRPPTGDILAISRIKEIHQRLPDTHLVMHGSSQVPQEW
LELINRFGGEIPETYGVPVEEVQEGIRNGVRKVNIDTDLRLASTGAVRKHLAENPSNFDPRKFLKASTEAMKEICKARYE
AFGSAGMASKIKPIALETMVERYESGELAPKVS

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=330, Percent_Identity=33.6363636363636, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=30.5135951661631, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1788072, Length=324, Percent_Identity=27.4691358024691, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38263; Mature: 38132

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMITLRQLLDHAAEHGYGMPAFNANNMEQLHAIMEAAKECDSPAIVQASAGARKYAGVP
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCCH
FYRHLMEAAVESYPDVPLVVHLDHGANPGACMRAIQSGFTSVMMDGSLKEDGKTPADYDY
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NASVTRRAAEMAHAGGVSVEGEIGVLGSLETGEAGKEDGVGAEGKMDKDKLLTDPEEAAQ
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHH
FVRDTHVDALAIACGTSHGAYKFTRPPTGDILAISRIKEIHQRLPDTHLVMHGSSQVPQE
HHHHHCHHHEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHH
WLELINRFGGEIPETYGVPVEEVQEGIRNGVRKVNIDTDLRLASTGAVRKHLAENPSNFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFLKASTEAMKEICKARYEAFGSAGMASKIKPIALETMVERYESGELAPKVS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AMITLRQLLDHAAEHGYGMPAFNANNMEQLHAIMEAAKECDSPAIVQASAGARKYAGVP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCCH
FYRHLMEAAVESYPDVPLVVHLDHGANPGACMRAIQSGFTSVMMDGSLKEDGKTPADYDY
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NASVTRRAAEMAHAGGVSVEGEIGVLGSLETGEAGKEDGVGAEGKMDKDKLLTDPEEAAQ
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHH
FVRDTHVDALAIACGTSHGAYKFTRPPTGDILAISRIKEIHQRLPDTHLVMHGSSQVPQE
HHHHHCHHHEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHH
WLELINRFGGEIPETYGVPVEEVQEGIRNGVRKVNIDTDLRLASTGAVRKHLAENPSNFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHCCCCCCC
PRKFLKASTEAMKEICKARYEAFGSAGMASKIKPIALETMVERYESGELAPKVS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]